My Wish Lists Login / Join

Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity

By: C. Jane Welsh (Editor), Mary Meagher (Editor), Esther Sternberg (Editor)

Write A Review

Hardcover | 12 September 2006

At a Glance

Hardcover
308 Pages

Dimensions(cm)
24.77 x 15.88 x 2.54

Hardcover

$249.00

or 4 interest-free payments of $62.25 with

Ships in 5 to 7 business days

This book provides a lucid summary of behavioral, neural and endocrine regulation of immune responses and of the effects of immune system activity on neural and endocrine functions and behavior. The underlying premise is that the brain and immune system represent a single, integrated system of defense. The discussion includes such topics and stress induced modulation of innate resistance and adaptive immunity in influenza viral infections.

Shipping

	Standard Shipping	Express Shipping
Metro postcodes:	$9.99	$14.95
Regional postcodes:	$9.99	$14.95
Rural postcodes:	$9.99	$14.95

Orders over $79.00 qualify for free shipping.

How to return your order

At Booktopia, we offer hassle-free returns in accordance with our returns policy. If you wish to return an item, please get in touch with Booktopia Customer Care.

Additional postage charges may be applicable.

Defective items

If there is a problem with any of the items received for your order then the Booktopia Customer Care team is ready to assist you.

For more info please visit our Help Centre.

Other Editions and Formats

Paperback

Published: 18th September 2014

View Product

Preface	p. vii
Acknowledgments	p. ix
Contributors	p. xi
Introduction	p. 1
Neural and Neuroendocrine Mechanisms in Host Defense: Molecular and Cellular Mechanisms	p. 5
Stress-induced Changes in Immune Cell Distribution and Trafficking: Implications for Immunoprotection versus Immunopathology	p. 7
Introduction	p. 7
Stress	p. 9
Stress-induced Changes in Blood Leukocyte Numbers	p. 9
Hormones Mediating Stress-induced Changes in Blood Leukocyte Numbers	p. 10
A Stress-induced Decrease in Blood Leukocyte Numbers Represents a Redistribution Rather Than a Destruction or Net Loss of Blood Leukocytes	p. 12
Target Organs of a Stress-induced Redistribution of Blood Leukocytes	p. 13
Acute Stress-induced Changes in Blood Leukocyte Numbers: Contradicting Results or a Biphasic Response?	p. 14
Stress-induced Redistribution of Blood Leukocytes: Molecular Mechanisms	p. 16
Stress-induced Redistribution of Blood Leukocytes: Functional Consequences	p. 16
Conclusion	p. 18
References	p. 19
Stress-induced Sympathetic Nervous System Activation Contributes to Both Suppressed Acquired Immunity and Potentiated Innate Immunity: The Role of Splenic NE Depletion and Extracellular Hsp72	p. 26
Introduction	p. 26
Excessive Sympathetic Nervous System Output Is Detrimental to Health	p. 27
Stress Modulates Immune Function: Acquired versus Innate	p. 27
Animal Model of Acute Stress	p. 28
Stress Suppresses Acquired Immunity	p. 28
In Vivo Generation of Antibody Against KLH Is a Measure of Acquired Immunity	p. 28
The Spleen Is Site for Stress-induced KLH Antibody Suppression	p. 29
Cellular Mechanisms of Stress-induced KLH Antibody Suppression	p. 29
Excessive Sympathetic Nervous System Response Suppresses Acquired Immunity	p. 30
Summary	p. 33
Stress Facilitates Innate Immunity	p. 33
Introduction	p. 33
Subcutaneous Bacterial Challenge Is a Measure of Innate Immunity	p. 34
Stress Facilitates Recovery from Subcutaneous E. coli Challenge: A Role for NO	p. 35
Stress and Extracellular Heat Shock Proteins	p. 36
Introduction	p. 36
Intracellular Heat Shock Proteins	p. 36
Extracellular Heat Shock Proteins	p. 36
Stress-induced Sympathetic Nervous System Output Stimulates eHsp72 Release	p. 37
Necrosis- versus Exocytosis-Mediated Release	p. 37
eHsp72 Release Involves Norepinephrine and [Alpha subscript 1]ADRs	p. 38
Immunostimulatory Effect of Extracellular Hsp72	p. 39
Extracellular Hsp72 and the Danger Theory	p. 39
Innate Immune Cell Activation: Toll-like Receptors Bind eHsp72	p. 40
Stress Facilitates Recovery from Subcutaneous E. coli Challenge: A Role for eHsp72	p. 41
Summary	p. 42
General Conclusions	p. 43
References	p. 44
Anthrax Lethal Factor Represses Glucocorticoid and Progesterone Receptor Activity	p. 57
Introduction	p. 57
Hypothalamic-Pituitary-Adrenal Axis and Glucocorticoid Responses	p. 57
Protective Features of an Intact HPA Axis and Glucocorticoid Response	p. 59
Diminished HPA Axis and GR Responses in Disease	p. 60
Anthrax Lethal Toxin	p. 62
Anthrax Lethal Toxin Repression of GR	p. 66
p38 MAPK and GR	p. 67
Therapeutic Implications	p. 68
References	p. 69
Adrenergic Regulation of Adaptive Immunity	p. 81
Introduction	p. 81
Sympathetic Innervation of Lymphoid Tissue and Norepinephrine Release	p. 81
Initial Evidence That Norepinephrine Plays a Role in Regulating Adaptive Immune Cell Activity	p. 83
Receptors for Adrenergic Receptors on Adaptive Immune Cells	p. 86
Effect of Norepinephrine and [Beta subscript 2]-Adrenergic Receptor Stimulation on Adaptive Immune Cell Activity	p. 88
Summary	p. 93
References	p. 94
Gender Dimorphism and the Use of Sex Steroid/Receptor Antagonist After Trauma	p. 101
Introduction	p. 101
Gender Dimorphism in Trauma Patients	p. 101
Sex Hormones and Response to Experimental Trauma	p. 103
Sex Hormones and Immune Response to Trauma	p. 103
Sex Hormones and Alterations in Cardiac Function	p. 105
Sex Hormones and Alterations in Hepatocellular Function	p. 106
Sex Hormones and Mortality in Animals After Trauma-Hemorrhage from Subsequent Sepsis	p. 106
Sex Hormone Receptors	p. 107
Use of Male Sex Hormone Receptor Antagonist	p. 107
Use of Female Sex Hormone Receptor Antagonist	p. 108
Synthesis of Sex Steroids	p. 108
Use of Inhibitors of Sex Steroid Synthesis	p. 111
Use of Sex Steroid Metabolites as Therapeutic Regimens After Trauma-Hemorrhage	p. 112
Additional Target for the Modulation of Sex Hormones and Their Influence on Post-Trauma Organ Functions	p. 113
Conclusion	p. 114
References	p. 114
Neural and Neuroendocrine Mechanisms in Host Defense: Physiological Effects of Stress on Host Susceptibility to Infection and Autoimmunity	p. 123
The Impact of Psychological Stress on the Immune Response to and Pathogenesis of Herpes Simplex Virus Infection	p. 125
Introduction	p. 125
Herpes Simplex Virus	p. 125
Immunity to HSV Infection	p. 126
Innate and Adaptive Immunity	p. 127
Memory Cytotoxic T Lymphocytes	p. 128
Psychological Stress and Immunity	p. 129
Stress and the Innate Immune Response to HSV Infection	p. 130
Inflammatory Response	p. 130
Leukocyte Trafficking and Recruitment	p. 131
Cells of the Innate Immune System	p. 132
Stress and the Adaptive Immune Response to HSV Infection	p. 133
Humoral Immunity	p. 133
Cellular Immunity	p. 134
The Impact of Stress on the Pathogenesis of HSV Infection	p. 136
Introduction	p. 136
The Impact of Stress on Primary HSV Infection	p. 136
The Impact of Stress on HSV Reactivation and Recurrent HSV Infection	p. 138
Human Studies	p. 138
Animal Studies	p. 138
The Impact of Stress on the Memory Immune Response to HSV Infection	p. 139
The Role of Stress in Preventing HSV Infections	p. 140
Concluding Remarks	p. 141
References	p. 142
Influenza Viral Infection: Stress-induced Modulation of Innate Resistance and Adaptive Immunity	p. 150
Introduction	p. 150
Immune Response to Influenza Viral Infection	p. 151
Innate Immune Response to Influenza Virus (Type I Interferons)	p. 152
Innate Immune Responses to Influenza Virus (Inflammation)	p. 152
Cell-mediated Immune Responses to Influenza Virus	p. 154
Immunological Memory to Influenza Virus	p. 155
Memory B-Cell Response to Influenza Virus	p. 156
Memory T-Cell Response to Influenza Virus	p. 157
Stress and the Immune Response to Influenza Virus	p. 160
Restraint Stress Suppresses the Immune Response to Infection with Influenza Virus	p. 162
Stress-induced Effects on Innate Immune Responses to Infection with Influenza Virus	p. 162
Stress-induced Effects on Adaptive Immunity to Infection with Influenza Virus	p. 165
Restraint Stress and T-Cell Responses	p. 165
Restraint Stress and B-Cell Responses	p. 166
Social Disruption Stress, Glucocorticoid Resistance, and the Immune Response to an Influenza Viral Infection	p. 166
Social Stress	p. 166
SDR and LPS Challenge	p. 167
SDR and Influenza Viral Infection	p. 168
General Conclusions	p. 168
References	p. 168
Autonomic Nervous System Influences on HIV Pathogenesis	p. 176
Introduction	p. 176
Catecholamine Acceleration of HIV-1 Replication	p. 179
Virologic Mechanisms	p. 179
The Neuroanatomic Basis of ANS Interactions	p. 183
Conclusion	p. 185
References	p. 186
The Effects of Restraint Stress on the Neuropathogenesis of Theiler's Virus-induced Demyelination: A Murine Model for Multiple Sclerosis	p. 190
Introduction	p. 190
Stress and the Immune System	p. 190
Multiple Sclerosis	p. 191
Stress and Multiple Sclerosis	p. 191
A Viral Etiology for Multiple Sclerosis	p. 192
Theiler's Virus-induced Demyelination as a Model for MS	p. 192
Interferon and NK Cells in Theiler's Virus Infection	p. 193
Role of CD8[superscript +] and CD4[superscript +] T Cells in Theiler's Virus Infection	p. 195
Th1/Th2 Responses in TVID	p. 196
Mechanisms of Theiler's Virus-induced Demyelination	p. 198
Stress Effects on the Neuropathogenesis of Theiler's Virus Infection	p. 199
General Restraint Procedures and Experimental Design	p. 199
Mice	p. 199
Virus	p. 199
Restraint Stress Protocol	p. 199
The Effects of Restraint Stress on Early Theiler's Virus Infection	p. 200
Restraint Stress Alters Chemokine/Cytokine mRNA Expression	p. 204
Restraint Stress Fails to Render TVID-Resistant Mice Susceptible to TVID	p. 205
The Effects of Restraint Stress During Acute Infection on the Later Demyelinating Disease	p. 206
The Effect of Restraint Stress During the Chronic Demyelinating Disease	p. 207
Summary and Significance of Research Findings	p. 207
References	p. 208
Social Stress Alters the Severity of an Animal Model of Multiple Sclerosis	p. 216
Introduction	p. 216
Multiple Sclerosis	p. 216
A Viral Etiology for MS	p. 217
Animal Models of Virus-induced Demyelination	p. 217
MS and Stress	p. 218
Theiler's Virus Infection as a Model for MS	p. 219
The Immune Response in TMEV Infection	p. 219
Theiler's Virus-induced Demyelination (TVID)	p. 220
Social Stress and Immunity	p. 220
Social Stress, Immunity, and Glucocorticoid Resistance in Mice	p. 221
Social Stress and Glucocorticoid Resistance in MS	p. 222
The Effects of Social Stress on TMEV Infection	p. 223
Effect of Social Stress During Acute TMEV Infection	p. 223
Social Stress, GC Resistance, and Exacerbation of Acute TMEV	p. 226
The Role of IL-6 in Mediating the Adverse Effects of Social Stress	p. 226
Clinical Significance of Acute Social Stress Effects	p. 228
Impact of Social Stress on Chronic TMEV Infection	p. 228
Neonatal Experience Alters the Impact of Social Stress	p. 230
General Conclusions	p. 231
References	p. 232
Early Postnatal Nongenetic Factors Modulate Disease Susceptibility in Adulthood: Examples from Disease Models of Multiple Sclerosis, Periodontitis, and Asthma	p. 241
The Development of Nongenetic Acquired Individual Differences	p. 241
Introduction	p. 241
Stress and Adaptation	p. 241
The Early Environment and Maternal Behavior in Rodents	p. 242
Modulation of Disease Susceptibility by Early Experiences	p. 244
Maternal Deprivation and Postnatal Handling Stimulation (Prolonged vs. Short Separation): Oppositional Paradigms of Early Deprivation and Stimulation	p. 244
Individual Differences in Response to Ligature-induced Periodontitis	p. 246
The Animal Model of Periodontitis	p. 246
Different Effects of HA and MD Depend on Genetics	p. 246
Amelioration of Disease Progress by Antidepressant Treatment	p. 247
Asthma	p. 248
Disease Model of Experimentally Induced Asthma Bronchiale	p. 248
Differential Effects of HA and MD	p. 248
Experimental Allergic Encephalomyelitis (EAE)	p. 250
Disease Model of EAE	p. 250
Imipramine as a Sufficient Treatment of MD-induced Aggravation of EAE	p. 250
Early Life Stress Increases Disease Susceptibility in Adulthood	p. 251
References	p. 252
The Relationship Between Stressful Life Events and Inflammation Among Patients with Multiple Sclerosis	p. 255
Introduction	p. 255
Brief Review of MS Pathology and Pathogenesis	p. 255
Evidence of the Relationship Between Stressful Life Events and MS Exacerbation	p. 257
Laboratory Studies of Acute Stress Responses in MS	p. 258
HPA	p. 259
Immune Responses to Acute Psychological Stressors in MS	p. 260
Three Hypotheses Regarding the Mechanisms by Which Stress Leads to Exacerbation	p. 261
Stress Resolution Hypothesis	p. 262
Development of Chronic Stress: Glucocorticoid Resistance	p. 263
Stress Onset: The Mast Cell Hypothesis	p. 264
Psychosocial Factors	p. 265
Psychosocial Mediators	p. 266
Psychosocial Moderators	p. 266
Summary and Future Directions	p. 267
References	p. 268
Index	p. 275
Table of Contents provided by Ingram. All Rights Reserved.

Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

Other Editions and Formats

Paperback

More in Virology excluding Medical

Prescott's Microbiology ISE

12th Edition

Darwin's Reach

21st Century Applications of Evolutionary Biology

Nester's Microbiology

A Human Perspective, 10th Edition

Instant Notes in Microbiology

The Pfizer Papers

Pfizer's Crimes Against Humanity

Entomological Health and Safety for Ecologists and Environmental Professionals

Entomological Health and Safety for Ecologists and Environmental Professionals

Disease X

The 100 Days Mission to End Pandemics

COVID-19

The Essentials of Prevention and Treatment

Viruses

Molecular Biology, Host Interactions, and Applications to Biotechnology

Viral Infections of Humans

Epidemiology and Control

COVID-19 A TCM Perspective

Encyclopedia of Virology, Fourth Edition

Darwin's Reach

21st Century Applications of Evolutionary Biology

Instant Notes in Microbiology

Advances in Applied Mechanics

Letters

Advances in Applied Microbiology

Advances in Applied Microbiology

Advances in Virus Research

Advances in Virus Research

Advances in Applied Microbiology

Advances in Applied Microbiology

Hepatitis B and the Prevention of Cancer of the Liver - Selected Publications of Baruch S. Blumberg

WS SERIES IN 20TH CENTURY BIOLOGY

Biotechnology and Plant Protection - Viral Pathogenesis and Disease Resistance

The Life of a Virus

Tobacco Mosaic Virus as an Experimental Model, 1930-1965

The Bacteriophages

Microbiology Fundamentals

5th Edition - A Clinical Approach: 2024 Release ISE

This product is categorised by