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Natural and Selected Synthetic Toxins : Biological Implications - Anthony T. Tu

Natural and Selected Synthetic Toxins

Biological Implications

Hardcover Published: 10th February 2000
ISBN: 9780841236301
Number Of Pages: 464

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This book looks at the latest information on a number of natural toxins, narcotics, and doping agents derived from marine, fungal, microbial, plant and animal origins. It examines the diversity of chemical classes among natural toxins and venoms as well as the biological effect and diverse action of toxicosis from these materials. There is a section on forensic toxicology that details selected synthetic toxins and several chapters on the biological effect of nerve agents such as sarin, which was used on human victims in the 1994 and 1995 subway attacks in Japan.

"In addition to contributions providing overviews of specific natural toxins, they often focus on the developmental potential for specific components of the crude natural toxin. Each contribution is variably illustrated with chemical structures, tables, and photographs of relevant toxic sources or cases. A neat overview of structure-function relationships between natural toxins and nerve agents introduced the volume. This is a "hot" topic presented in a scholarly readable fashion. The editors have called upon their international colleagues to update the scientific community on the exciting work being performed to isolate, characterize, and nominate practical applications for this highly potent group of naturally-occurring toxins." -- Veterinary and Human Toxicology "In addition to contributions providing overviews of specific natural toxins, they often focus on the developmental potential for specific components of the crude natural toxin. Each contribution is variably illustrated with chemical structures, tables, and photographs of relevant toxic sources or cases. A neat overview of structure-function relationships between natural toxins and nerve agents introduced the volume. This is a "hot" topic presented in a scholarly readable fashion. The editors have called upon their international colleagues to update the scientific community on the exciting work being performed to isolate, characterize, and nominate practical applications for this highly potent group of naturally-occurring toxins." -- Veterinary and Human Toxicology "In addition to contributions providing overviews of specific natural toxins, they often focus on the developmental potential for specific components of the crude natural toxin. Each contribution is variably illustrated with chemical structures, tables, and photographs of relevant toxic sources or cases. A neat overview of structure-function relationships between natural toxins and nerve agents introduced the volume. This is a "hot" topic presented in a scholarly readable fashion. The editors have called upon their international colleagues to update the scientific community on the exciting work being performed to isolate, characterize, and nominate practical applications for this highly potent group of naturally-occurring toxins." -- Veterinary and Human Toxicology "In addition to contributions providing overviews of specific natural toxins, they often focus on the developmental potential for specific components of the crude natural toxin. Each contribution is variably illustrated with chemical structures, tables, and photographs of relevant toxic sources or cases. A neat overview of structure-function relationships between natural toxins and nerve agents introduced the volume. This is a "hot" topic presented in a scholarly readable fashion. The editors have called upon their international colleagues to update the scientific community on the exciting work being performed to isolate, characterize, and nominate practical applications for this highly potent group of naturally-occurring toxins." -- Veterinary and Human Toxicology "In addition to contributions providing overviews of specific natural toxins, they often focus on the developmental potential for specific components of the crude natural toxin. Each contribution is variably illustrated with chemical structures, tables, and photographs of relevant toxic sources orcases. A neat overview of structure-function relationships between natural toxins and nerve agents introduced the volume. This is a "hot" topic presented in a scholarly readable fashion. The editors have called upon their international colleagues to update the scientific community on the excitingwork being performed to isolate, characterize, and nominate practical applications for this highly potent group of naturally-occurring toxins." -- Veterinary and Human Toxicology

Prefacep. xi
Structure--Function Relations of Natural Toxins and Nerve Agents: An Overviewp. 1
Marine, Fungal, and Microbial Toxins
Cytotoxins and Other Bioactive Compounds from Coral Reef Organismsp. 12
Cellular Signaling in PC12 Cells Affected by Pardaxinp. 22
Anti-Aflatoxigenic Constituents of Pistacia and Juglans Speciesp. 43
Current Research on Mycotoxins: Fumonisinsp. 54
Bacterial Typing and Identification by Mass Spectrometryp. 67
Plant Toxins
Pyrrolizidine Alkaloids: Physicochemical Correlates of Metabolism and Toxicityp. 100
Transfer of Pyrrolizidine Alkaloids into Eggs: Food Safety Implicationsp. 118
Calystegine Alkaloids in the Potato and Other Food Plantsp. 129
New Alkaloids from Phalaris Spp.: A Cause for Concern?p. 140
Natural Toxins from Poisonous Plants Affecting Reproductive Function in Livestockp. 154
Mechanistic Investigation of Veratrum Alkaloid-Induced Mammalian Teratogenesisp. 173
Analysis and Fractionation of Cigarette Tar Extracts: What Causes DNA Damage?p. 188
Molecular Neurosurgery: Using Plant Toxins to Make Highly Selective Neural Lesionsp. 194
Plant-Associated Hepatogenous Photosensitization Diseasesp. 204
Animal Toxins
Probing the Structure, Function, Dynamics, and Folding of Snake Venom Cardiotoxinsp. 222
Structures and Pharmacological Activities of Phospholiase A[subscript 2]s from Agkistrodon halys Pallasp. 249
Snake Venom Disintegrin: An Effective Inhibitor of Breast Cancer Growth and Disseminationp. 262
Lethal Toxins of Lizard Venoms That Possess Kallikrein-Like Activityp. 283
Nerve Agents and Doping Compounds
Overview of Sarin Terrorist Attacks in Japanp. 304
Toxicological Analysis of Victims' Blood and Crime Scene Evidence Samples in the Sarin Gas Attack Caused by the Aum Shinrikyo Cultp. 318
An Attack with Sarin Nerve Gas on the Tokyo Subway System and Its Effects on Victimsp. 333
Preparedness against Nerve Agent Terrorismp. 356
Determination of Metabolites of Nerve Agent O-Ethyl-S-2-Diisopropylaminoethyl Methylphosphonothioate (VX)p. 369
Natural Compounds and Dopingp. 387
Indexes
Author Indexp. 399
Subject Indexp. 401
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780841236301
ISBN-10: 0841236305
Series: ACS Symposium Series
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 464
Published: 10th February 2000
Publisher: American Chemical Society
Country of Publication: US
Dimensions (cm): 23.6 x 15.7  x 2.5
Weight (kg): 0.74