NATO Science Partnership Subseries

3

By: Athel Cornish-Bowden (Editor), Maria Luz CÃ¡rdenas (Editor)

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Hardcover | 29 February 2000

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Hardcover
392 Pages

Dimensions(cm)
24.13 x 16.51 x 2.54

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Two decades have passed since the mechanisms of protein synthesis became well enough understood to permit the genetic modification oforganisms. An impressive amount of new knowledge has emerged from the new technology, but much ofthe promise of20years ago has notyet been fulfilled. In biotechnology, efforts to increase the yields of commercially valuable metabolites have been less successful than ex pected, and when they have succeeded it has often been as much from selective breeding as from new methods. The cell is more complicated than what is presented in the classical teaching of biochemistry, it contains more structure than was dreamed of 20 years ago, and the behaviour ofany systemofenzymes is more elaborate than can be explained in terms ofa single supposedly rate-limiting enzyme. Even if classical enzymology and meta bolism may have seemed rather unfashionable during the rise ofmolecular biology, they remain central to any modification ofthe metabolic behaviour oforganisms. As such modification is essential in much ofbiotechnology and drug development, bio technologists can only ignore these topics at their peril.

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Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems
Snapshots of systems: metabolic control analysis and biotechnology in the post-genomic era	p. 3
Moiety conservation and flux enhancement	p. 27
On the universality of the universal method	p. 33
Imposing Discipline: Manipulation of Organisms for Technological Ends
Life is complicated	p. 41
Regulation and redirection of metabolism: incorporating regulatory information in flux calculation	p. 49
Recent development in metabolic pathway analysis and their potential implications for biotechnology and medicine	p. 57
Quantifying the importance of regulatory loops in homeostatic control mechanisms: hierarchical control of DNA supercoiling	p. 67
An integrated approach to the analysis of the control and regulation of cellular systems	p. 73
Understanding Health and Disease: Why Organisms Behave as they do
Mechanism of carcinogenesis by polycyclic aromatic hydrocarbons: aneuploidy precedes malignant transformation and occurs in all cancers	p. 83
Metabolic control analysis shows how aneuploidy causes cancer	p. 99
The control strength of glucokinase in hepatocytes: a predictor of metabolic defects in maturity onset diabetes of the young, type 2	p. 109
Metabolic distress associated with impaired control by alternative substrates: two examples taken from purine metabolism	p. 117
Regulation of ATP supply in muscle: implications for importance of flux control coefficients and for the genesis of mitochondrial myopathies	p. 125
Regulation of energy metabolism in hepatocytes	p. 131
Combined NMR experimental and computer-simulation study of 2,3-bisphosphoglycerate metabolism in human erythrocytes	p. 139
Taking Aim: Use of Metabolic Models to Identify Drug Targets
Computational approaches to the study of biochemical pathways and metabolic control	p. 149
Using metabolic control analysis to improve the selectivity and effectiveness of drugs against parasitic diseases	p. 157
Computer simulation as a tool for studying metabolism and drug design	p. 165
Use of metabolic control analysis to design a new strategy for cancer therapy	p. 173
Facing Reality: Not just a Bag of Enzymes
Implications of cytoarchitectural analysis	p. 183
Probing the cell interior with NMR spectroscopy	p. 191
Metabolite channelling and protein-protein interactions in the urea synthesis pathway	p. 199
Intracellular distribution of glycogen synthase: Another regulatory mechanism of glycogen metabolism?	p. 207
Supramolecular organization and substrate channelling in the mammalian translation system	p. 215
Analysis of co-localization of glycolytic enzymes in flight muscle and its relation to muscle function in Drosophila	p. 223
Thinking about Metabolism: The Relationship between Control and Regulation
Metabolic control from the back benches: biochemistry towards biocomplexity	p. 235
Physiological consequences of a non-regulated mutant phosphofructokinase in Escherichia coli	p. 243
Time-dependent or steady-state control of metabolic systems?	p. 251
Multisite modulation in the control of glycolysis: balance of supply and demand?	p. 259
Exercising control when control is distributed	p. 267
Metabolic control design: implications and applications	p. 275
Determining elasticities in situ	p. 283
Coordination and homeostasis in the response to multiple signals: role of metabolic cascades	p. 289
Putting the cart before the horse: designing a metabolic system in order to understand it	p. 299
Predicting the structural design of metabolic pathways: an evolutionary approach	p. 309
Glycogen structure: an evolutionary view	p. 319
Taking Stock: Control Analysis in the Context of Metabolic Regulation
From control to regulation: a new prospect for metabolic control analysis	p. 329
Metabolic control and metabolons in the millennium	p. 339
In memoriam: Paul Srere, 1925-1999	p. 347
Contributors	p. 351
Index	p. 355
Table of Contents provided by Syndetics. All Rights Reserved.

NATO Science Partnership Subseries

3

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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