Nanoparticles in Cancer Therapy

This book presents the role of nanoparticles in cancer therapy, emphasizing their innovative applications across treatment, diagnosis, and the development of therapeutic strategies. The first section introduces the fundamentals of cancer biology alongside the various nanoparticles utilized in cancer therapy. The second section discusses the applications of nanoparticles in cancer vaccines and gene therapy. It features discussions on polymeric nanoparticles as nanovaccine carriers, membrane-based nano-vaccines for immunotherapy, and gene therapy techniques employing nanoparticles. The third section presents the advanced nanomedicine approaches, detailing the role of chemodynamic nanoparticles in cancer theranostics, the application of low-dimensional nanomaterials, and emerging strategies against drug resistance. Additionally, it explores nanotechnology in radiation therapy, phototherapy modalities, and bioengineered virus-like nanoparticles for diagnostics and therapeutics. The final sections review the clinical applications and prospects, examining theranostic nanoparticles, the clinical translation of nanomedicine, and the current limitations of cancer nanotherapy. It also addresses future directions in nanoparticle application, and examines the genotoxicity, immunotoxicity, cytotoxicity assessments, safety profiles, targeted drug delivery, and their role in viral oncogenesis. This book is a useful resource for researchers, clinicians, and students in the fields of oncology and nanotechnology.