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Multiple Drug Resistance in Cancer 2 : Molecular, Cellular and Clinical Aspects :  Molecular, Cellular and Clinical Aspects - Martin Clynes

Multiple Drug Resistance in Cancer 2 : Molecular, Cellular and Clinical Aspects

Molecular, Cellular and Clinical Aspects

By: Martin Clynes (Editor)

Hardcover

Published: January 1999
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Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.

Introduction
Dedication
Acknowledgement
P-glycoprotein structure and evolutionary homologiesp. 1
Molecular analysis of the multidrug transporter, P-glycoproteinp. 31
Mutagenesis of the putative nucleotide-binding domains of the multidrug resistance associated protein (MRP). Analysis of the effect of these mutations on MRP mediated drug resistance and transportp. 61
Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologsp. 71
A new aspect on glutathione-associated biological function of MRP/GS-X pump and its gene expressionp. 81
Intracellular distribution of anthracyclines in drug resistant cellsp. 95
Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistancep. 113
Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRPp. 137
Topoisomerase I inhibitors and drug resistancep. 149
Mechanisms of resistance to alkylating agentsp. 165
Drug resistance and DNA repair in leukaemiap. 175
Nucleotide excision repair and anti-cancer chemotherapyp. 187
Protein kinases and multidrug resistancep. 203
New insights into the kinetic resistance to anticancer agentsp. 225
The extended-MDR phenotypep. 237
Role of oxygenation and vascularization in drug resistancep. 249
Transcriptional regulation of MDR genesp. 257
Cytokine-mediated reversal of multidrug resistancep. 271
The role of oncogene in drug resistancep. 283
Apoptosis resistance in tumor cellsp. 293
Regulation of caspase activation in apoptosis: implications for transformation and drug resistancep. 309
Regulation of keratin and Integrin gene expression in cancer and drug resistancep. 321
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792352723
ISBN-10: 0792352726
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 344
Published: January 1999
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 26.04 x 19.68  x 1.91
Weight (kg): 1.02
Edition Number: 2