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Multidisciplinary Treatment of Soft Tissue Sarcomas : Cancer Treatment and Research - J. Verweij

Multidisciplinary Treatment of Soft Tissue Sarcomas

Cancer Treatment and Research

By: J. Verweij (Editor), H. M. Pinedo (Editor), H. D. Suit (Editor)

Hardcover Published: December 2009
ISBN: 9780792321835
Number Of Pages: 191

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The purpose of this book is to contribute to the further development of the multidisciplinary approach to the treatment of soft tissue sarcomas. A proper diagnosis and staging remains the cornerstone of the treatment strategy. Sophisticated histopathology techniques and growing consensus on grading systems have further increased the importance of the histopathologist in providing estimates of the prognosis of the patient as well as providing data for the planning of treatment strategy. The use of cytogenetics is relatively new in this field. This might enable distinction of subgroups in specific histological tumor types. Further to this, molecular biological studies not only help to reveal inherited predispositions and details in oncogenesis in tumor development, but they may also provide additional predictive factors for tumor behaviour. Further data for the treament strategy will be provided by diagnostic imaging, in which field the role of magnetic resonance imaging is rapidly developing. As far as actual treatment is concerned, surgery still provides the major chance for cure. In view of the endeavour to be as sparing as possible, the addition of radiotherapy to surgery is of utmost importance. Usually radiotherapy is given after surgery, but the optimal sequence of the two modalities yet needs to be defined. The combined use of surgery with radiotherapy and/or chemotherapy does have an impact on wound healing. A review on recent data concerning wound healing in these situations has thus been added. There appears to be growing consensus about the role of chemotherapy in metastatic disease, where only doxorubicin, ifosfamide and DTIC are known to be active. Although it may be different for subsets, in general, single-agent chemotherapy appears to be as effecive as standard doses of combination chemotherapy. The lack of efficacy of adjuvant chemotherapy with standard doses of the drugs presently available has been shown. Just as for radiotherapy, chemotherapy may have an important role in the preoperative treatment of advanced soft tissue sarcomas, where intravenous drug administration appears to be as effective as the more complicated intraarterial administration. Thermochemotherapy, another and still investigational approach to advanced local disease, also yields interesting preliminary results. Finally, clinical behaviour, treatment strategy and the outcome of treatment in childhood soft tissue sarcomas are quite different from those in adult soft tissue sarcomas.

Industry Reviews

'....this is an extremely well-done contribution of interest to practicing oncologist irregardless of subspecialty. Each chapter is an excellent synopsis reminiscent of stand-alone review articles appearing in prestigious oncologic journals.' Oncology 51:5 1994

Preface
Contributing Authors
List of Abbreviations
Pathology and Grading of Soft Tissue Sarcomasp. 1
Cytogeneticsp. 23
Molecular Biological Studies on Soft Tissue Sarcomasp. 37
Diagnostic Imagingp. 57
Surgical Wound Healingp. 81
Preoperative Radiation Therapy for Patients with Sarcoma of the Soft Tissuesp. 99
Changing Concepts in the Systemic Treatment of Locally Advanced or Metastatic Soft Tissue Sarcomasp. 107
Adjuvant Chemotherapy of Soft Tissue Sarcomasp. 117
Preoperative Chemotherapy for Soft Tissue Sarcomas of the Extremities: The Experience at the University of California, Los Angelesp. 135
Hyperthermia and Thermochemotherapyp. 143
Soft Tissue Sarcomas in Childrenp. 161
Indexp. 183
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792321835
ISBN-10: 0792321839
Series: Cancer Treatment and Research
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 191
Published: December 2009
Publisher: SPRINGER VERLAG GMBH
Country of Publication: US
Dimensions (cm): 23.39 x 15.6  x 1.27
Weight (kg): 0.47

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