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Mononuclear Phagocytes : Biology of Monocytes and Macrophages - R.Van Furth

Mononuclear Phagocytes : Biology of Monocytes and Macrophages

By: R.Van Furth (Editor)

Hardcover Published: 1992
ISBN: 9780792318439
Number Of Pages: 668

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Mononuclear phagocytes, which include macrophages, monocytes and their precursor cells, are the most important cells in the host defence against micro-organisms and tumor cells. During the last twenty-five years research on the biology of mononuclear phagocytes has increased tremendously. This motivated Professor R. van Furth to organize five international conferences on this subject in Leiden, the Netherlands. The edited proceedings of these meethings were published: in 1970 Mononuclear Phagocytes; in 1975 Mononuclear Phagocytes in Immunity, Infections and Pathology; in 1980 Mononuclear Phagocytes -- Functional Aspects; and in 1985 Mononuclear Phagocytes -- Characteristics, Physiology and Function. Reviews of these volumes, published in international journals, praised them as the most up-to-date state of the art publications. The publication of 1991 includes 88 chapters written by more than 200 authors.

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Development and Distribution of Mononuclear Phagocytes
Production and migration of monocytes and kinetics of macrophagesp. 3
The biology and action of colony stimulating factor-1p. 13
The contribution and limitations of CR3-dependent recruitment of macrophages to inflammatory and lymphoid sitesp. 21
Lymphocyte-monocyte locomotor interaction and clusteringp. 31
Macrophage-microglia responses to excitotoxin-induced degeneration in the central nervous systemp. 37
The role of macrophages in different stages of experimental allergic encephalomyelitis in Lewis ratsp. 45
Haemopoiesis during infection in mice: an inducible genetically controlled response mediated by CD4[superscript +] T cells homing to their bone marrowp. 50
Cellular interactions between stromal macrophages and haematopoietic cellsp. 55
The role of intestinal dendritic cells in antigen presentationp. 70
Migration and maturation of non-lymphoid dendritic cellsp. 75
Monocyte-Endothelial Cell Interactions
Endothelial-dependent mechanisms of monocyte adhesionp. 83
Adhesion molecules of human monocytesp. 92
Human monocytes exhibit different mechanisms of adhesion to non-stimulated or cytokine-stimulated human endothelial cellsp. 105
Activation of LFA-1, and its role in mediating adhesion of monocytes and lymphocytes to endotheliump. 117
Monocyte adhesion to rIL-4 stimulated human endothelial cellsp. 123
The importance of leukocyte integrin activation in myeloid cell interaction with endotheliump. 129
Mechanisms of monocyte adhesion to activated human endothelium in vitrop. 134
PECAM-1: an adhesion molecule at the junctions of endothelial cellsp. 138
Involvement of ELAM-1 in monocyte adherence to and migration across IL-1-stimulated endothelial cell monolayersp. 149
Localized expression of a mononuclear leukocyte adhesion molecule by vascular endothelium during atherogenesisp. 155
Endothelial cell activation and mononuclear cell infiltration during allergic and irritant contact dermatitisp. 161
Biology of Surface Receptors
Fc receptor function in macrophages and lymphocytesp. 169
Polymorphism and functioning of a low-affinity IgG Fc receptor, hFc[gamma]RII (CD32)p. 177
Regulation of leukocyte integrinsp. 183
Membrane surface antigen expression on human monocytes: changes during purification, in vitro activation and transmigration across monolayers of endothelial cellsp. 188
Monocyte/macrophage receptors for proteins modified by advanced glycation end products: role in normal tissue remodeling and in pathologyp. 193
Modulation of endothelial function and endothelial-monocyte interaction by advanced glycosylated end products of proteinsp. 202
The mannose receptor and phagocytosisp. 208
Receptor-mediated endocytosis and phagocytosis share common determinants for intracellular traffickingp. 214
Carbohydrate recognition receptors of the macrophage and their regulationp. 224
The regulation of urokinase plasminogen activator gene expression in macrophagesp. 233
Microbicidal Mechanisms
Generation of reactive oxygen species by phagocytesp. 243
Immune therapy and potential for gene therapy in chronic granulomatous disease of childhoodp. 254
Antimicrobial mechanisms of macrophagesp. 259
Defensins in macrophagesp. 268
Antimicrobial polypeptides in mouse macrophagesp. 273
Synthesis of nitric oxide from L-arginine: a cytokine inducible pathway with antimicrobial activityp. 279
Killer and target: a tale of two cellsp. 293
Stimulation of interleukin-1[beta] release from human monocytes by the action of pore-forming bacterial toxinsp. 303
Ingestion of pulmonary surfactant by human monocytes inhibits their antibacterial functionsp. 308
Biochemical basis for the candidacidal mechanisms of human mononuclear phagocytesp. 315
Production of Cytokines by Macrophages
Effects of interleukin-1 and related cytokines on host defense against infectionsp. 323
Functional activity of IL-4 cultured human peripheral blood monocytesp. 328
Interleukin-6: its role in the cytokine networkp. 333
Interleukin-8: a chemotactic cytokine produced by macrophages and tissue cellsp. 340
Tumor necrosis factor. Induction and biological effects in humansp. 346
LPS reactivity of monocytes and TNF gene polymorphismp. 355
Soluble and cell surface TNF receptors for tumor necrosis factorp. 359
Cytokine gene expression in situ: differential expression of lysozyme, IL-1, and TNF mRNA in murine liver during BCG infectionp. 366
Anti-cytokinesp. 375
Regulation of macrophage functions by macrophage deactivating factor, a tumor cell-derived cytokinep. 381
Properties and binding characteristics of monocyte chemotactic and activating factor (MCAF)p. 389
Lysozyme gene expression in macrophages and specialized epithelial cellsp. 397
The role of macrophage-derived growth factors in tissue repairp. 404
Intracellular Regulatory Pathways
Chemoattractant stimulus-response couplingp. 413
Molecular bases of macrophage activation: regulation of class II MHC genes in tissue macrophagesp. 425
Signal transduction in resident and activated macrophagesp. 437
Myristoylated protein kinase C substrates and intracellular signaling pathways in macrophagesp. 451
Regulation of IFN[gamma]/IL-2 induced macrophage gene expressionp. 463
Understanding how macrophages recognize bacterial lipopolysaccharidep. 468
Participation of the cytoskeleton in macrophage responses to LPSp. 472
Cytoskeletal changes during Fc receptor-mediated phagocytosisp. 478
The role of calcium and protein kinase C in intracellular killing of bacteria by human monocytesp. 483
ATP-induced pores and gap junctions in macrophagesp. 489
Macrosialin, a macrophage endosomal sialoprotein differentially glycosylated in response to inflammatory stimulip. 494
Intracellular protein tyrosine kinases of the src family in mononuclear phagocytesp. 500
Intracellular Microorganisms and Macrophages
The role of interferon-[gamma] in inflammationp. 511
Activation of macrophage antimicrobial activities: complex interactions of cytokines for induction of resistance to infection and intracellular destruction of pathogensp. 517
Priming/activation of macrophages for antileishmanial activity: role of TNF-[alpha] and nitric oxide in killing of Leishmania donovanip. 523
Towards an understanding of the molecular basis for Legionella pneumophila pathogenesisp. 528
Intracellular killing of Candida albicans by activated peritoneal macrophagesp. 534
Cytokine and viral gene expression during infection of monocytes by the human immunodeficiency virus: central role of interferons in the promotion and resolution of virus infectionp. 540
Uptake of antibiotics by monocytes and macrophagesp. 550
Transport of organic anions and antibiotics in macrophagesp. 554
Cell-Mediated Immunity
The initiation of cell-mediated immune responsesp. 561
Epidermal Langerhans cells in cell-mediated immunityp. 572
T cell-phagocyte interactions induced by listeria monocytogenesp. 577
Cytokines produced by T cell subset-depleted naive and listeria-immune spleen cellsp. 583
Pathogenesis of Listeria monocytogenesp. 593
Macrophage activation by recombinant cytokinesp. 602
Effect of interferon-[gamma] on the development of inflammatory lesions in the liver of mice during infection with Listeria monocytogenesp. 618
The role of TNF in listeriosisp. 626
Monokines in cell-mediated immunity to bacterial infectionsp. 631
Control of mycobacterial infection by interleukin-activated macrophagesp. 636
Leprosy a model for cell-mediated immunity: the effects and consequences of recombinant lymphokine immunotherapyp. 644
Cell-mediated immunity to mycobacteria: the effect of cytolysis on parasite viabilityp. 649
Activation of murine peritoneal macrophages by the mycobacterial 65 kD heat-shock proteinp. 651
Interaction between activated macrophages and Mycobacterium fortuitump. 657
Subject Indexp. 665
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792318439
ISBN-10: 0792318439
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 668
Published: 1992
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 27.31 x 20.32  x 4.45
Weight (kg): 1.59

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