Monoclonal Antibodies

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Paperback | 27 March 1995

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500 Pages

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24.41 x 16.99 x 2.57

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Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject. Monoclonal antibodies provide highly specific reagents with which to identify, analyse, quantitate and manipulate molecules - both in solution and in solid phase, such as at a cell surface. The aim of this book is therefore to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications of these antibodies in many areas of clinical medicine, including histopathology, oncology, transplantation, infectious diseases, rheumatology, haematology and dermatology.

Industry Reviews

'This book provides a timely overview of the production and application of mAbs ... if everyone using mAbs in their research were to read this then the work of referees might be much reduced ... a valuable resource to anyone working with, or contemplating working with, mAbs.' Alan Trudgett, Society for General Microbiology Quarterly '... provides a comprehensive account of the different techniques available for the generation of mabs.' Molecular Medicine Today 'The editors have done a fine job. There is little redundancy between chapters, the text is clear and all the contributions are well referenced.' British Toxicology Society Newsletter '... an excellent source of primary reference material ... The book is extremely suited as an introduction to monoclonal antibodies for clinicians from different areas of clinical medicine.' Federation of European Biochemical Sciences

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Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Immunology Medicine in General Medical Equipment & Techniques Medical Research Medical Laboratory Testing & Techniques Other Branches of Medicine Pathology

Introduction
Production of monoclonal antibodies
Antigen-antibody interactions: how affinity and kinetics affect assay design and selection procedures
The production and characterisation of synthetic peptide-derived antibodies
Human monoclonal antibodies
Bispecific monoclonal antibodies
The production of antibodies using phage display libraries
Genetic manipulation of monoclonal antibodies
Monoclonal antibodies in diagnostic immunoassays
Monoclonal antibodies in diagnostic pathology
In vivo targeting of monoclonal antibodies for immunoscintigraphy and therapy of human malignancies
Monoclonal antibodies in infectious disease: diagnosis
Monoclonal antibodies in the prophyllaxis and therapy of infectious disease
Monoclonal antibodies in transplantation: immunohistology
Monoclonal antibodies in transplantation: experimental studies on in vivo immunosuppression
Monoclonal antibodies in transplantation: prophyllaxis of graft-versus-host disease after bone marrow transplantation
Monoclonal antibodies in transplantation: use as therapeutic agents in clinical organ transplantation
Monoclonal antibodies and the skin
Monoclonal antibodies in endocrinology
Monoclonal antibodies in rheumatology
Technical appendix
Table of Contents provided by Publisher. All Rights Reserved.

Monoclonal Antibodies

At a Glance

Paperback

Industry Reviews

Shipping

How to return your order

Defective items

You Can Find This Book In

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