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Molecular Targeting and Signal Transduction : Cancer Treatment and Research - Rakesh Kumar

Molecular Targeting and Signal Transduction

Cancer Treatment and Research

By: Rakesh Kumar (Editor)

Hardcover

Published: 30th April 2004
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Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general. "Modern cancer therapy targets critical signalling molecules responsible for cell proliferation. This text describes the key pathways and factors involved in this process. Distinguished leaders in the field discuss the therapeutic compounds and strategies being developed for the treatment of malignant disease." - Steven T. Rosen, M.D., Series Editor

Biology of the epidermal growth factor receptor familyp. 1
Integrin signaling in cancerp. 15
Regulators of vascular endothelial growth factor expression in cancerp. 33
Integrin-linked kinase (ILK) in combination molecular targetingp. 59
p21-activated kinase 1 : an emerging therapeutic targetp. 77
Basis and importance of Src as a target in cancerp. 89
Therapeutic targeting of the receptor tyrosine kinase metp. 121
Nuclear factor -[kappa]B activation mediates cellular transformation, proliferation, invasion, angiogenesis and metastasis of cancerp. 139
The p53 pathway : targets for the development of novel cancer therapeuticsp. 175
Runx protein signaling in human cancersp. 189
Signal transduction mediated by cyclin D1 : from mitogens to cell proliferation : a molecular target with therapeutic potentialp. 217
Signal transduction pathways in Bcr-Abl transformed cellsp. 239
Estrogen receptors and anti-estrogen therapiesp. 271
Targeting endothelin axis in cancerp. 293
km23 : a novel TGF[beta] signaling target altered in ovarian cancerp. 315
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9781402078224
ISBN-10: 1402078226
Series: Cancer Treatment and Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 331
Published: 30th April 2004
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 0.71