An engagingly written, vibrantly illustrated reference that expertly links neurobiology, clinical psychiatry, and neurology Molecular Neuropharmacology first reviews the fundamental biochemistry of the functioning nervous system and then describes in clear, concise and consistent terms how nerve cells communicate with one another through numerous types of neurotransmitters involving amino acids, monoamines, neuropeptides, and neurotrophic factors, among several others.
The neuropharmacology and neural circuits that underlie complex behaviors as well as major neural disorders are then discussed as are the drugs used to treat those conditions.
In this final section, the authors use the concepts presented in the first two sections to explain how irregularities in the biochemistry of neuronal interactions can lead to a wide array of clinical manifestations. Key points begin every chapter for a brief overview.
Each chapter is packed with figures, tables and text boxes (presented on every page and accessible with clear color coding). More than 300 detailed diagrams provide specific information on receptor and drug families, biosynthetic and metabolic pathways, and interactions between the nervous system and the rest of the body. Simple and elegant, these illustrations are rich enough in content to serve as brief overviews of each chapter when viewed alone.
Features NEW chapter on neuroinflammation All chemical structure illustrations have been redrawn and improved Fully updated to reflect the latest breakthroughs and new drugs The best written and most easily understood work on the subject
About the Author
Eric J. Nestler, MD, PhD (New York, NY) Nash Family Professor of Neuroscience; Chairman, Department of Neuroscience andDirector of the Mount Sinai Brain Institute,Mount Sinai School of Medicine. Steven E. Hyman, MD (Cambridge, MA) Director, Stanley Center for Psychiatric Research,Broad Institute; Distinguished Service Professor of Stem Cell and Regenerative BiologyHarvard University. Robert C. Malenka, MD, PhD (Palo Alto, CA)Nancy Friend Pritzker Professor of Psychiatryand Behavioral Sciences;Director, Nancy Friend Pritzker Laboratory,Stanford University School of Medicine. David M. Holtzman, MD (St. Louis, MO)Andrew B. and Gretchen P. Jones Professor of Neurology Charlotte and Paul Hagemann Professor of NeurologyChairman, Department of NeurologyProfessor, Molecular Biology and PharmacologyWashington University School of Medicine in St. LouisNeurologist-in-Chief, Barnes-Jewish Hospital.
1. Fundamentals of Neuropharmacology1. Basic Principles of Neuropharmacology2. Cellular Basis of Communication3. Synaptic Transmission4. Signal Transcuction in the Brain2. Neural Substrates of Drug Action5. Excitatory and Inhibitory Amino Acids6. Monoamines, Acetylcholine, and Orexin7. Neuropeptides8. Atypical NeurotransmittersNeuropharmacology of Neural Systems and Disorders9. Autonomic Nervous System10. Neural and Neuroendocrine Control of Internal Mileau11. Pain 12. Neuroinflammation13. Sleep and Arousal14. Cognitive Function and Behavior15. Mood and Emotion16. Reinforcement and Addiction17. Schizophrenia and Other Psychoses18. Neurodegeneration19. Seizures20. Stroke and Migraine
Series: Internal Medicine
Number Of Pages: 544
Published: 12th January 2015
Publisher: McGraw-Hill Education - Europe
Country of Publication: US
Dimensions (cm): 25.0 x 18.0
Weight (kg): 0.81
Edition Number: 3
Edition Type: Revised