Molecular Mechanisms of Synaptogenesis

By: Alexander Dityatev (Editor), Alaa El-Husseini (Editor)

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Hardcover | 1 January 2006

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524 Pages

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24.77 x 17.15 x 3.18

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Some of the molecules critical for building neuronal contacts have been shown to be affected in psychiatric disorders such as autism and mental retardation. Also, a reduction in synapse number in specific brain regions has been found in patients with brain disorders. Thus, imbalance in synaptic contact formation may result in the formation of abnormal neuronal circuits and the aberrant behavior manifested in these brain diseases. Recent findings also suggest that fine tuning of neuronal circuits rather than a major loss of neurons may be the cause of some of these brain disorders. In certain cases, loss of neurons could be a secondary event reflecting problems in improper neuronal communication.

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"This volume provides a comprehensive overview and perspectives on the interplay between development, maturity, and disease that is valuable to the newcomer and expert alike. One strength of this volume is that it highlights the breadth of the many experimental systems and approaches that are used to study normal development as well as synaptic defects associated with human diseases. ... This volume provides an excellent resource to both established investigators and newcomers to the field." (Ethan G. Hughes and Rita J. Balice-Gordon, Neuron, Vol. 53, 2007)

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Non-Fiction Medicine Clinical & Internal Medicine Neurology & Clinical Neurophysiology Engineering & Technology Other Technologies & Applied Sciences Applied Optics Laser Technology & Holography Technology in General Engineering in General Science Biology, Life Sciences

Life Sciences in General Neurosciences

Overview : synaptogenesis : when long-distance relations become intimate	p. 1
Experimental models of synaptogenesis	p. 11
The formation of the vertebrate neuromuscular junction : roles for the extracellular matrix in synaptogenesis	p. 13
Synapse formation between identified molluscan neurons : a model system approach	p. 29
Development of the Drosophila and C. Elegans neuromuscular junctions	p. 43
Mechanisms that regulate neuronal protein clustering at the synapse	p. 67
Roles of cell adhesion and secreted molecules in synaptic differentiation	p. 81
Cadherin-mediated adhesion and signaling during vertebrate central synapse formation	p. 83
Synaptic functions of the neural cell adhesion molecular (NCAM)	p. 97
Role of neuroligin binding to neurexins in synaptic organization	p. 111
SynCam in formation and function of synaptic specializations	p. 125
Protocadherins and synapse development	p. 137
Ephrins and EPH receptors in spinogenesis and synaptic plasticity	p. 151
Extracellular matrix molecules and formation of CNS synapses	p. 163
Role of neurotrophins in the formation and maintenance of synapses	p. 179
Transport of synaptic proteins	p. 195
Motor-cargo interactions involved in transport of synaptic proteins	p. 197
Postsynaptic transport packets	p. 209
Lateral diffusion of excitatory neurotransmitter receptors during synaptogenesis	p. 221
Synaptic cytoskeleton and morphogenic signaling	p. 233
Assembly of presynaptic active zones	p. 235
Assembly of postsynaptic protein complexes in glutamatergic synapses	p. 247
Regulation of dendritic spine morphology and synaptic function by scaffolding proteins	p. 261
Composition and assembly of gabaergic postsynaptic specializations	p. 277
Role of synaptogenesis in morphologic stabilization of developing dendrites	p. 297
Protein kinases and synaptogenesis	p. 311
Signaling from synapse to nucleus and back	p. 333
Synaptic plasticity in learning and memory	p. 347
Structural synaptic correlates of learning and memory	p. 349
Intracellular trafficking of AMPA-type glutamate receptors	p. 365
Learning-induced changes in sensory synaptic transmission	p. 377
Synaptogenesis and brain disorders	p. 389
Relevance of presynaptic proteins to neuropsychiatric disorders	p. 391
Synaptic abnormalities and candidate genes in autism	p. 409
Synaptic pathology in depression	p. 419
Synaptic pathology in dementia	p. 431
A fragile synapse : changes at the synapse in fragile X syndrome	p. 445
Synaptic abnormalities associated with Huntington's disease	p. 457
Interference peptides : a novel therapeutic approach targeting synaptic plasticity in drug addiction	p. 473
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Molecular Mechanisms of Synaptogenesis

At a Glance

Hardcover

Industry Reviews

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