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Molecular Diversity in Drug Design - P. M. Dean

Molecular Diversity in Drug Design

By: P. M. Dean (Editor), Richard A. Lewis (Editor)

Hardcover Published: 31st October 1999
ISBN: 9780792359807
Number Of Pages: 254

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High-throughput screening and combinatorial chemistry are two of the most potent weapons ever to have been used in the discovery of new drugs. At a stroke, it seems to be possible to synthesise more molecules in a month than have previously been made in the whole of the distinguished history of organic chemistry, Furthermore, all the molecules can be screened in the same short period. However, like any weapons of immense power, these techniques must be used with care, to achieve maximum impact. The costs of implementing and running high-throughput screening and combinatorial chemistry are high, as large dedicated facilities must be built and staffed. In addition, the sheer number of chemical leads generated may overwhelm the lead optimisation teams in a hail of friendly fire. Mother nature has not entirely surrendered, as the number of building blocks that could be used to build libraries would require more atoms than there are in the universe. In addition, the progress made by the Human Genome Project has uncovered many proteins with different functions but related binding sites, creating issues of selectivity. Advances in the new field of pharmacogenomics will produce more of these challenges. There is a real need to make hi- throughput screening and combinatorial chemistry into 'smart' weapons, so that their power is not dissipated. That is the challenge for modellers, computational chemists, cheminformaticians and IT experts. In this book, we have broken down this grand challenge into key tasks.

Industry Reviews

`This excellent work can be recommended unreservedly for natural sciences students in the final of a degree course and for research scientists... The excellent articles by Peter Willett and Jonathan Mason are sufficient reason ... for buying the book. The authors and editors of this book have laid a solid foundation...'
Angewandte Chemie, 39:15 (2000)

Contributors
Acknowledgements
Preface
Issues in Molecular Diversity and the Role of Ligand Binding Sitesp. 1
Molecular Diversity in Drug Design. Application to High-Speed Synthesis and High-Throughput Screeningp. 23
Background Theory of Molecular Diversityp. 43
Absolute vs Relative Similarity and Diversityp. 67
Diversity in Very Large Librariesp. 93
Subset-Selection Methods For Chemical Databasesp. 115
Molecular Diversity in Site-focused Librariesp. 141
Managing Combinatorial Chemistry Informationp. 175
Design of Small Libraries for Lead Explorationp. 197
The Design of Small- and Medium-sized Focused Combinatorial Librariesp. 221
Indexp. 249
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792359807
ISBN-10: 0792359801
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 254
Published: 31st October 1999
Publisher: SPRINGER VERLAG GMBH
Country of Publication: NL
Dimensions (cm): 24.79 x 16.15  x 2.03
Weight (kg): 0.57

Earn 519 Qantas Points
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