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Molecular Biology of the Islets of Langerhans - Hiroshi Okamoto

Molecular Biology of the Islets of Langerhans

By: Hiroshi Okamoto (Editor)

Hardcover

Published: 23rd February 1990
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A comprehensive account of the role of the islets of Langerhans is presented in this text. As the primary source of hormone production in the pancreas, the islets of Langerhans have been the focus of research into the nature of diabetes for decades. In recent years, the molecular biology of this multiendocrine organ has been intensively investigated, with a corresponding increase in our understanding of the normal and pathological functioning of islet cells. This is the first comprehensive treatment of molecular studies on the synthesis of insulin, glucagon, somatostatin and pancreatic polypeptide. In addition, this volume presents contemporary hypotheses and explanations, at the molecular level, of the defects in islet cells that may lead to diabetes.

"Indisputably this book will provoke a real interest among the endocrinologists, biochemists, molecular biologists and all investigators working in the area of diabetes research." R. Wegmann, Cellular and Molecular Biology

Preface Hiroshi Okamoto
Introductory overview
The Molecular Biology of Peptide Hormones in the Islets of Langerhans
The organization and structure of insulin genes
The regulation of insulin gene expression
The translational control of proinsulin synthesis by glucose
The structure and regulation of the glucagon gene
The structure and regulation of the somatostatin gene
The mosaic evolution of the pancreatic polypeptide gene
The structure and expression of genes of vasoactive intestinal peptide and related peptides
Pancreastatin: a novel pancreatic hormone
The processing of peptide precursors
Molecular Aspects of Diabetes Mellitus
The molecular basis of experimental diabetes
Class II histocompatibility genes and diabetes
The role of the insulin gene in diabetes: use of restriction fragment length polymorphisms in diagnosis
Abnormal products of the human insulin gene
A novel gene, rig, activated in insulinomas
Defects of signal transduction in a tumoral islet cell line
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780521362047
ISBN-10: 0521362040
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 364
Published: 23rd February 1990
Publisher: Cambridge University Press
Country of Publication: GB
Dimensions (cm): 22.8 x 15.2  x 2.4
Weight (kg): 0.7