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Molecular Biology of Drug Addiction - Rafael Maldonado

Molecular Biology of Drug Addiction

By: Rafael Maldonado (Editor)

Hardcover

Published: 12th September 2002
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A comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological basis of drug addiction. The authors explore the latest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine addiction, provide fresh insights into the genetic basis of drug addiction and the new therapeutic perspectives these have opened. They describe the technology available to generate conditional knockout mice and show how these mice can reveal the molecular basis of opioid, psychostimulant, and cannabinoid addiction. They also review the different behavioral models available to evaluate the rewarding effects of drugs and analyze the genes involved in alcohol dependence.

"I found this text to be a wonderful compilation...each chapter highlighted the use of recently established techniques to provide an improved understanding of the role of specific membrane transport pathways, hormone receptors, intracellular signaling pathways and even circulating hormone and drug levels deep within the brain." -Pharmaceutical Research

Prefacep. v
Contributorsp. ix
Opioid Addiction
Molecular Mechanisms of Opioid Dependence by Using Knockout Micep. 3
Molecular Genetic Approachesp. 27
Opiate Addiction: Role of the cAMP Pathway and CREBp. 37
Different Intracellular Signaling Systems Involved in Opioid Tolerance/Dependencep. 45
Inhibitors of Enkephalin Catabolism: New Therapeutic Tool in Opioid Dependencep. 61
Psychostimulant Addiction
Recent Advances in the Molecular Mechanisms of Psychostimulant Abuse Using Knockout Micep. 79
Opioid Modulation of Psychomotor Stimulant Effectsp. 107
Influence of Environmental and Hormonal Factors in Sensitivity to Psychostimulantsp. 133
Development and Expression of Behavioral Sensitization: Temporal Profile of Changes in Gene Expressionp. 161
Cannabinoid Addiction
New Advances in the Identification and Physiological Roles of the Components of the Endogenous Cannabinoid Systemp. 173
Integration of Molecular and Behavioral Approaches to Evaluate Cannabinoid Dependencep. 199
Opioid System Involvement in Cannabinoid Tolerance and Dependencep. 221
Alcohol and Nicotine Addiction
Current Strategies for Identifying Genes for Alcohol Sensitivityp. 249
Genetic Basis of Ethanol Rewardp. 263
Behavioral and Molecular Aspects of Alcohol Craving and Relapsep. 295
Molecular and Behavioral Aspects of Nicotine Dependence and Rewardp. 315
Indexp. 339
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9781588290601
ISBN-10: 1588290603
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 346
Published: 12th September 2002
Publisher: SPRINGER VERLAG GMBH
Country of Publication: US
Dimensions (cm): 24.94 x 19.51  x 2.69
Weight (kg): 0.89