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Molecular Biology in Medicinal Chemistry : Methods and Principles in Medicinal Chemistry - Theodor Dingermann

Molecular Biology in Medicinal Chemistry

Methods and Principles in Medicinal Chemistry

By: Theodor Dingermann (Editor), Dieter Steinhilber (Editor), Gerd Folkers (Editor), Raimund Mannhold (Editor), Hugo Kubinyi (Editor)

Hardcover Published: 13th February 2004
ISBN: 9783527304318
Number Of Pages: 435

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This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods.<br> With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

Industry Reviews

"...a welcome addition to the library of anyone seeking to build a multidisciplinary group"
Applied Organometallic Chemistry, June 2004

"In all, the book touches on some of the trendiest subjects that interface to form the frontier of modern medicinal chemistry."

Kevin G. Rice, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Journal of Medicinal Chemistry, Vol. 47, No. 26, 2004

MOLECULAR TARGETS
Cellular Assays in Drug Discovery
Gene Knockout Models
Reporter Gene Assay Systems for the Investigation of GPCRs
From the Human Genome to New Drugs: The Potential of Orphan GPCRs
SYNTHESIS
Stereoselective Synthesis with the Help of Recombinant Enzymes
Nucleic Acid Drugs
ANALYSIS
Recent Trends in Enantioseparation of Chiral Drugs
Affinity Chromatography
NMR-based Drug Discovery
13C- and 15N-Isotopic Labeling of Proteins
Antibody Fragments as Crystallization Enhancers
KINETICS, METABOLISM AND TOXICOLOGY
Pharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug Response
Pharmacogenomics of Bioavaliability and Elimination
Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology

ISBN: 9783527304318
ISBN-10: 3527304312
Series: Methods and Principles in Medicinal Chemistry
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 435
Published: 13th February 2004
Publisher: Wiley-VCH Verlag GmbH
Country of Publication: DE
Dimensions (cm): 241.3 x 25.83  x 173.99
Weight (kg): 0.97
Edition Number: 1

Earn 511 Qantas Points
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