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Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes : NATO A S I SERIES SERIES A, LIFE SCIENCES - Emel Arinc

Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

NATO A S I SERIES SERIES A, LIFE SCIENCES

By: Emel Arinc (Editor), John B. Schenkman (Editor), Ernest Hodgson (Editor)

Hardcover Published: 1st January 1999
ISBN: 9780306460487
Number Of Pages: 294

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Written by leading researchers in the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and cancer, this is a comprehensive update on molecular biology and biochemistry of cytochromes P450 and flavin containing monoxygenases. The volume provides expert analysis of the genetic polymorphism of these enzymes in the clinic, in drug discovery and development, and discussion of their role in predisposition for, and prevention of chemical carcinogens in humans.

The Fate of Xenobiotics in the Body: Enzymes of Metabolismp. 1
Protein-Protein Interactions in the P450 Monooxygenase Systemp. 21
Structures of Mitochondrial P450 System Proteinsp. 41
Biochemical Aspects of Flavin-Containing Monooxygenases (FMOs)p. 55
Expression and Regulation of Flavin-Containing Monooxygenasesp. 71
Correlations between in Vivo and in Vitro Studies in Human Drug Metabolismp. 81
Pharmacogenetics: Polymorphisms in Xenobiotic Metabolismp. 91
Clinical Aspects of Polymorphic Drug Metabolism in Humansp. 111
Genetic Polymorphisms of Cytochromes P450 1A1 and 2E1 and of Glutathione S-Transferase M1 and Cancer Susceptibility in the Humanp. 127
Cytochrome P450 Isoforms: Insecticide Metabolism in Insects and Mammals and Role in Insecticide Resistancep. 145
Inhibitors of CYP51 as Antifungal Agents and Resistance to Azole Antifungalsp. 157
The Role of Oxidative Drug Metabolizing Enzymes in Liver and Lung Specific Toxicityp. 173
Importance of Drug Metabolism in Drug Discovery and Developmentp. 183
Aflatoxin Biotransformation and Toxicologyp. 195
Role of Individual Enzymes in the Control of Genotoxic Metabolitesp. 211
Enhancement of the Mutagenicity of Ethylene Oxide and Several Directly Acting Mutagens by Human Erythrocytes and Its Reduction by Xenobiotic Interactionp. 221
Cytochrome P4501A1 (Cyp 1A1) and Associated MFO Activities in Fish as an Indicator of Pollution with Special Reference to Izmir Bayp. 247
Cyp 1A Concentrations as an Indicator of Exposure of Fish to Pulp-Mill Effluentsp. 259
The Biochemistry and Physiology of Prostacyclin- and Thromboxane-Synthasep. 271
Cell Engineering of the Rat and Human Cysteine Conjugate Beta Lyase Genes and Applications to Nephrotoxicity Assessmentp. 283
Indexp. 293
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780306460487
ISBN-10: 0306460483
Series: NATO A S I SERIES SERIES A, LIFE SCIENCES
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 294
Published: 1st January 1999
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.15  x 1.91
Weight (kg): 0.61