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Modulation of Cardiac Calcium Sensitivity : A New Approach to Increasing the Strength of the Heart - J. A. Lee

Modulation of Cardiac Calcium Sensitivity

A New Approach to Increasing the Strength of the Heart

By: J. A. Lee (Editor), David G. Allen (Editor)

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Calcium sensitizers are a new class of drug which increases the force of contraction of the heart by increasing the calcium sensitivity of contractile proteins. Their development represents the first major innovation in the treatment of heart failure for over 200 years. Unlike other drugs in this area, they do not increase the intracellular calcium concentration and do not have the side effects associated with that mechanism of action. These drugs offer an exciting alternative approach to the treatment of heart failure, and this volume provides an authoritative overview of the physiology, biochemistry, and clinical issues involved. It will be of interest to pharmacologists, research and clinical cardiologists, and physiologists.

Industry Reviews

'At £45, it will be most readily available in the well found library, where it may stimulate the enquiring student.' R.A. Chapman, Cardiovascular Research, May 1994

1: J.A. Lee and D.G. Allen: Altering the strength of the heart: basic mechanisms 2: J.D. Strauss, J.C. Ruegg, and I. Lues: In search of calcium sensitizer compounds: from subcellular models of music to in vivo positive intropic action 3: J.C. Kentish and S. Palmer: The influence of pH phosphate, and ionic strength of contraction in skinned cardiac muscle 4: C.H. Orchard, D.G. Allen, M.R. Boyett, A.C. Elliott, and M.S. Kirby: The effects of acidosis on intact cardiac muscle 5: Natural calcium-sensitizing compounds of the heart 6: S.C. O'Neill, P. Donoso, C. Lamont, and D.A. Eisner: The effects of caffeine on cardiac muscle 7: R.J. Solaro: Modulation of activation of cardiac myofilaments by beta-adrenergic agonists 8: I. Morano: Myosin light chain phosphorylation and myosin isoenzyme expression regulate cardiac calcium sensitivity by modulation of cross-bridge cycling kinetics 9: B. Brenner: Changes in calcium sensitivity at the cross-bridge level 10: J. Gulati, A. Babu, R. Cheng, and H. Su: The genetic engineering and physiology of troponin C: molecular aspects of the modulation of cardiac calcium sensitivity 11: J.R. Blinks: Analysis of the effects of drugs on myofibrillar Ca2+ sensitivity in intact cardiac muscle 12: D.G. Allen, J.A. Lee, and A.C. Elliott: Effects of anoxia and ischaemia on cardiac muscle 13: E. Marban: Changes in myofibrillar calcium responsiveness in the post-ischaemic heart (stunned myocardium) 14: N.R. Alpert, G. Hasenfuss, C. Holubarsch, and L.A. Mulieri: Energetic aspects of altering myocardial sensitivity to calcium 15: C. Holubarsch and G. Hasenfuss: Clinical experience with calcium sensitizers in congestive heart failure 16: J.A. Lee and D.G. Allen: Future directions Index

ISBN: 9780192623478
ISBN-10: 0192623478
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 358
Published: 18th March 1993
Country of Publication: GB
Dimensions (cm): 23.4 x 15.6  x 2.6
Weight (kg): 0.77