The most recent trends in human leukemia, which were discussed at the Ninth Wilsede Meeting, are presented in this volume. The internationally renowned contributors discuss both clinical aspects as well as biomedical studies. They present new information about the biological basis of leukemia which has been gained using the methods of molecular genetics, cell and molecular biology, virology and immunology. The evidence clearly shows both the complexity of leukemia research, as well as the value of basic scientific research in furthering clinical medicine and therapy.
Clinical Aspects.- Bone Marrow Transplantation in Children with Acute Leukemia: A 1990 View.- Proliferation-Including Effects of Recombinant Human Interleukin-7 and Interleukin-3 in B-Lineage Acute Lymphoblastic Leukemia.- Effects of Granulocyte Colony-Stimulating Factor in Children with Severe Congenital Neutropenia.- Interleukin-1 Production in Patients with Nonlymphocytic Leukemia and Myelodysplastic Syndromes.- The Results of Treatment of Acute Lymphoblastic Leukemia Relapses in the Polish Children's Leukemia/Lymphoma Study Group.- Long-Term Follow-up Study in Childhood Acute Lymphoblastic Leukemias.- Monoclonal Blast Cell Proliferation in Transient Myeloproliferative Disorder.- The Comparison of the Expression of Activation Antigens on Peripheral Blood Mononuclear Cells in Chronic Lymphocytic Leukemia and in Hairy Cell Leukemia.- Multiple Myeloma: Immunodeficient, Osteolytic, Renal, and Amyloid Syndromes.- Prognostic Factors in Patients with Multiple Myeloma.- Cytogenetic Disorders During Tumor Progression in Leukemia.- New Cytogenetic Aspects of Myelodysplasia and Acute Leukemia.- Detection of Minimal Residual Leukemia by Polymerase Chain Reactions.- Structural Changes in Blast Cell Chromatin and DNA in Patients with Acute Leukemia After Cytosar and Irradiation Treatment.- Cell Biology.- Animal Models of Normal and Leukemic Human Hematopoiesis.- Colony Stimulating Factors: Regulation of Production.- Adhesive Interactions in the Regulation of Haemopoiesis.- In Vitro Effect of GM-CSF and IFN-? on the Establishment of Stromal Layer and Hemopoiesis in Human Dexter Culture.- The Effect of Bone Marrow Fibroblast and Stromal Cell-Conditioned Media on Hemopoietic Cells in Culture.- Hemopoietic Stem Cells in Embryogenesis of the Mouse.- Induction of Differentiation of the Human Promyelocytic Cell Line (HL-60) by Conditioned Medium of Ceathea letifera-Stimulated Mononuclear Cells.- Molecular Mechanisms in Myeloid Lineage Development.- Proteoglycans in Cellular Recognition and Secretory Functions in the Haemopoietic System.- Modification of the In Vitro Replication of the Human Immunodeficiency Virus HIV-1 by TPSg, a Polysaccharide Fraction Isolated from the Cupressaceae Thuja occidentalis L. (Arborvitae).- Molecular Genetics.- Molecular Cloning and Expression of CD 34: A Haemopoietic Progenitor-Associated Cell Surface Glycoprotein.- Molecular Genetics of the Human GM-CSF Receptor.- Structural Organization of the Cytokine Gene Cluster on Human Chromosome 5.- Genes Encoding Tumor Necrosis Factors: Genome Organization, Polymorphism, and Expression.- Molecular Characterization of the Mouse Interleukin-3 Receptor.- Signal Transduction Through Foreign Growth Factor Receptors and Oncogenes Transfected into Interleukin-3-Dependent Hematopoietic Cells.- Genetic Analysis of Ion Transport.- Virology.- The Molecular Biology of the Myeloproliferative Leukemia Virus.- Raf Function is Required for Proliferation of NIH/3T3 Cells and Transformation by Nonnuclear Oncogenes.- erbB*a: an "Ignition Spark" for the Xiphorus Melanoma Machinery?.- Analysis of Human Retroviral Regulatory Proteins Tax and Tat.- Human Neuroblastoma: Paradigm for a Tumor with Oncogene Amplification and Loss of a Putative Tumor Suppressor Gene.- Activation of Gene Expression by Human Herpes Virus 6.- Expression of S71-Related Sequences in Human Cells.- Selective Integration of Rous Sarcoma Virus Genome in High- and Low-Metastatic Transformed Cell Lines.- Molecular Mechanism of Alteration of H-ras I Oncogene in Human Breast Carcinomas: G to T Transversion in 12th Codon of the Undeleted Allele in the Case of the Loss of the Other Gene Allele.- Immunology.- Natural Killer Cell Mediated Defence Directed Selectively Against Target Cells Lacking MHC Class I Gene Products.- Tumor Rejection Antigens and Immune Surveillance.- Glycophosphatidylinositol-Anchored Membrane Proteins as Coreceptors in T-Cell Activation.- The Molecular Mechanism of Muramyl Peptides' Biological Activity.- A Novel Nuclear Factor Binds to the NF-KB Motif in the Interleukin-2 Enhancer.- Soluble Cytokine Receptors as Immunomodulators.- Early Life and Evolution.- Immunological Self-Nonself Discrimination and Numerous Peptide Fragments Shared by Unrelated Proteins.- Multigene Families: The Problem of Molecular Recapitulation.- Repeated Intragenome "Parasites" as a Factor in Molecular Coevolution.- Frozen Temporal Pattern in Growing Systems.- On Some Concepts in Modeling Nonlinear Phenomena.
Series: Lecture Notes in Artificial Intelligence
Number Of Pages: 345
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6
Weight (kg): 0.66