| Frontiers in the Mathematical Description of "Biothermokinetic" Phenomena | p. 3 |
| Monitoring a Heterogeneous Coupled System Using Soluble and Biologically Localized Firefly Luciferase as a Probe for Bulk and Local [ATP] | p. 7 |
| Control of Cytochrome C Oxidase: Kinetic, Thermodynamic or Allosteric? | p. 11 |
| Mechanism of Bupivacaine Uncoupling in Rat Heart Mitochondria | p. 17 |
| Mosaic Non-Equilibrium Thermodynamics as a Tool in the Study of Oxidative Phosphorylation | p. 23 |
| The Redox State of Cytochromes as a New Tool to Assess the Thermodynamic State of Mitochondria | p. 27 |
| Thermodynamic Response Paradigm and its Application to Oxidative Phosphorylation | p. 33 |
| A Model Study on the Interrelation between the Transmembrane Potential and pH Difference across the Mitochondrial Inner Membrane | p. 39 |
| Comparison of Retinal-Based and Chlorophyll-Based Photosynthesis: A Biothermokinetic Description of Photochemical Reaction Centers | p. 45 |
| Regulation of Energy Flux of Yeast during Steady State and Oscillatory Growth | p. 53 |
| Free-Energy Coupling Mediated by Dynamic Interactions between Membrane Proteins | p. 61 |
| Characterization of Energy-Dependent Phosphate Uptake by Blue-Green Alga Anacystis nidulans: Adaptation to External Phosphate Levels Obeys a Linear Flow-Force Relation | p. 67 |
| Brownian Dynamics Simulation of Charged Membrane Components: Implications for their Lateral Distribution and Voltage Dependence of Ion Transport through Membranes | p. 71 |
| Evolutionary Strategies and the Optimization of Carrier Models | p. 77 |
| Mathematical Model of the Creatine Kinase Reaction Coupled to Adenine Nucleotide Translocation and Oxidative Phosphorylation | p. 85 |
| Critical Regulation of Multienzyme Complexes: A Kinetic Model for the Mammalian Pyruvate Dehydrogenase Complex | p. 93 |
| The Analysis of Flux in Substrate Cycles | p. 97 |
| Estimation of Enzymatic Flux Rates from Kinetic Isotope Experiments | p. 103 |
| When Going Backwards Means Progress: On the Solution of Biochemical Inverse Problems Using Artificial Neural Networks | p. 109 |
| Quality Assessment of a Metabolic Model and Systems Analysis of Citric Acid Production by Aspergillus niger | p. 115 |
| Steady-State Measurements and Identifiability of Regulatory Patterns in Metabolic Studies | p. 125 |
| A Biochemical "NAND" Gate and Assorted Circuits | p. 133 |
| Dynamic Modeling of Cell, Substrate, and Product Concentrations and pH in E. coli-Containing Agar Membranes | p. 141 |
| The Interpretation of Flow Cytometry Profiles in Terms of Gene Dosage and Gene Expression | p. 149 |
| Invention of a Useful Transcriptional Regulation System Using Mechanistic Mathematical Modeling | p. 155 |
| Tumor Progression and Catastrophe Theory | p. 159 |
| Biochemical Neuron: Application to Neural Network Studies and Practical Implementation of Device | p. 167 |
| Example of the Use of Computers to Study the Variability of Seed Development of a Parasitic Weed, Striga hermonthica (Del.) Benth. (Scrophulariaceae), after Treatment by Herbicide | p. 173 |
| Responses of Metabolic Systems to Large Changes in Enzyme Activities | p. 179 |
| An Extension of Metabolic Control Analysis to Larger Parameter Perturbations by Inclusion of Second-Order Effects | p. 187 |
| A Control Analysis of Metabolic Regulation | p. 193 |
| Regulation and Homeostasis in Metabolic Control Theory: Interplay between Fluctuations of Variables and Parameter Changes | p. 199 |
| Sum of the Flux Control Coefficients: What is it Equal to in Different Systems? | p. 205 |
| Control Analysis of Metabolic Channeling | p. 211 |
| Path Analysis in General Control Theory | p. 217 |
| Phenomenological Kinetics and the Top-Down Approach to Metabolic Control Analysis | p. 225 |
| A Modular Approach to the Description of the Control of Connected Metabolic Systems | p. 229 |
| Control Analysis of Isoenzymic Pathways: Application of Directed Graphs and Electrical Analogs | p. 237 |
| Derivation of a General Matrix Method for the Calculation of Control Coefficients | p. 243 |
| Internal Regulation. The [actual symbol not reproducible] Square-Matrix Method Illustrated for a Simple Case of a Complex Pathway | p. 253 |
| Multiplicity of Control | p. 263 |
| Control of Threonine Biosynthesis in E. coli | p. 269 |
| Control Coefficients in Cellular Cation Homeostasis: A Model Analysis | p. 275 |
| Experimental Discrimination between Proton Leak across the Mitochondrial Membrane and Slip in the Proton Pumps of the Electron Transport Chain | p. 283 |
| Does Redox Slip Contribute Significantly to Mitochondrial Respiration? | p. 287 |
| Mechanistic Stoichiometry of Yeast Mitochondrial Oxidative Phosphorylation: A Behavior of Working Engine | p. 295 |
| Mitochondrial Creatine Kinase: Biothermokinetics of the Reaction and its Role in the Regulation of Energy Fluxes in Muscle Cells in vivo | p. 301 |
| Effect of Macromolecules on ADP-Channeling into Mitochondria | p. 313 |
| Control of ATP Flux in Rat Muscle Mitochondria | p. 319 |
| Control of Respiration of Mitochondria from Euglena gracilis Determined by Means of Metabolic Control Analysis: Comparison of Oxidation of Matrix- and Cytosolic NADH | p. 327 |
| Top Down Metabolic Control Analysis of Oxidative Phosphorylation at Different Rates in Potato Tuber Mitochondria | p. 333 |
| The Influence of Phosphate on the Distribution of Flux Control among the Enzymes of Oxidative Phosphorylation in Rat Skeletal Muscle Mitochondria | p. 339 |
| The Molecular Basis of Threshold Effects Observed in Mitochondrial Diseases | p. 343 |
| Control of Respiration in Heart Mitochondria: Comparative Study of Oxidation of Succinate and NAD-Dependent Substrates | p. 347 |
| Mechanisms of the Effects of Hypothyroidism and Hyperthyroidism in Rats on Respiration Rate in Isolated Hepatocytes | p. 351 |
| Substrate and Calcium Dependence of the Pyridine Nucleotide and Flavine Redox State in Rat Heart Mitochondria Respiring at Different Metabolic States | p. 357 |
| Modification of Mitochondrial Metabolism by Amino Acid-Induced Cell Swelling | p. 369 |
| Estimation of the Mechanism of Peptide Binding to HLA Class II Molecules | p. 377 |
| Shift of a Peptide Bond Equilibrium towards Synthesis Caltalyzed by [alpha]-Chymotrypsin | p. 383 |
| Modulation of Cellular Energy State and DNA Supercoiling in E. coli | p. 391 |
| Cascade Control of Ammonia Assimilation | p. 397 |
| Photovoltage Measurements as a Probe of Light Distribution and Ion Movements around Photosynthetic Apparatus | p. 401 |
| Neural Networks Applied to Cell Signaling and Chemical Communication in Cell Networks | p. 407 |
| Synchronization of Glycolytic Oscillations in Intact Yeast Cells | p. 413 |
| Control in Electrophysiology and Intracellular Signal Transduction | p. 417 |
| Structure-Function Relationship of Magainins. Studies in Liposomal Model Systems | p. 423 |
| The Communication between the Mitochondrial and Cytosolic Branches of Energy Metabolism | p. 427 |
| Calculation of Metabolic Fluxes by Mathematical Modeling of Carbon-13 Distribution in Metabolites. I. Presentation of the Mathematical Model | p. 435 |
| Calculation of Metabolic Fluxes by Mathematical Modeling of Carbon-13 Distribution in Metabolites. II. Application to the Study of C6 Cell Metabolism | p. 443 |
| MLAB: An Advanced System for Mathematical and Statistical Modeling | p. 451 |
| SIMFIT - A Computer Package for Simulation, Curve Fitting and Statistical Analysis Using Life Science Models | p. 455 |
| Optimal Design for Model Discrimination: Choosing the Best Spacing and Density of Design Points | p. 459 |
| GEPASI: A User Oriented Metabolic Simulator | p. 463 |
| Object Oriented Simulation of Metabolic Processes | p. 467 |
| MetaCon - A Computer Program for the Algebraic Evaluation of Control Coefficients of Metabolic Networks | p. 473 |
| Champagne in Holland: An Experiment in Oenology | p. 481 |
| Index | p. 485 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
