Thirty per cent of all women and ten per cent of all men experience migraine. This crippling illness does not kill, but its high morbidity poses a massive economic problem and gives rise to considerable suffering. Its main manifestation, headache, is subjective, and there are no animal models. This makes traditional research approaches difficult, and has led to a variety of research strategies. In this study, leaders in migraine research present the numerous
advances that have been made over the past two decades in our understanding of this disorder, and discuss in depth the position of migraine research today and the directions it will take in the future.
'well presented papers, good diagrams and mostly understandable text ... Each paper is a small gem, describing the present state of research and drawing reasonable conclusions. As a source of reference it is unrivalled.'
Dr Duncan Anderson, Doctor
'The book is a comprehensive introduction and explores in depth some of the unresolved issues.'
Trends in Neurosciences
'Tthe book is an excellent review of the latest work on the migraine syndrome...should be part of any hospital lobrary and is obviously a necessity for those individuals that treat many individuals with head pain.'Physicians Postgraduate Press
Merton Sandler: Introduction; J.N. Blau: The nature of migraine: do we need to invoke slow neurochemical processes?; Discussion; J.W. Lance, G.A. Lambert, P.J. Goadsby, & A.S. Zagami: Contribution of experimental studies to understanding the pathophysiology of migraine; Discussion; Kathleen R. Merikangas: Genetic epidemiology of migraine; Discussion; Ryszard J. Gryglewski & John R. Vane: A possible role of endothelial vasorelaxants in the
pathogenesis of migraine; Discussion; Sergio H. Ferreira: A classification of peripheral analgesics based upon their mode of action; Discussion; Michael A. Moskowitz, Damianos E. Sakas, Michihisa Kano, Hermes A. Kontos, &
Enoch P. Wei: Vasomotor functions of trigeminovascular fibres: inferences from lesion studies; Discussion; Jes Olesen, Tom Skyhøj Olsen, & Lars Friberg: Regional cerebral blood flow in migraine; Discussion; K.M.A. Welch: Migraine pathogenesis examined with contemporary techniques for analysing brain function; Discussion; Michael A. Moskowitz & M. Gabriella Buzzi: The superior pericarotid cavernous sinus plexus and cluster headaches; Discussion; J.R. Fozard: 5-HT in
migraine: evidence from 5-HT receptor antagonists for a neuronal aetiology; Discussion; P.P.A. Humphrey, W. Feniuk, & M.J. Perren: 5-HT in migraine: evidence with 5-HT1-like receptor agonists for a vascular aetiology; G. Curzon,
G.A. Kennett, K. Shah, & P. Whitton: Behavioural effects of m-chlorophenylpiperazine (m-CPP), a reported migraine precipitant; Discussion; P.R. Saxena: 5-HT receptors and migraine; Discussion; P.R. Saxena: Is there still a case for the shunt hypothesis in migraine?; Discussion; General discussion I; Lars Edvinsson, Inger Jansen, & Rolf Uddman: Peptidergic mechanisms in human intracranial and extracranial arteries; Discussion; J.C. Schwartz, B. Giros, C. Gros, C. Llorens-Cortes,
J.M. Arrang, M. Garbarg, & H. Pollard: Novel agents affecting enkephalinergic and histaminergic transmissions in the brain; Discussion; Vivette Glover & Merton Sandler: The biochemical basis of migraine
predisposition; Discussion; Kathleen R. Merikangas & Jules Angst: Depression and migraine; Discussion; Richard C. Peatfield: Pain, headache, and depression: a discussion; Discussion; Richard C. Peatfield: A note on the role of platelets in migraine: a personal view; Discussion; J. de Belleroche: Differential abnormalities in signal transduction in migraine and cluster headache; Discussion; F. Clifford Rose: The current status of migraine therapy; Discussion; A. Ziegler: Treatment: where
are we going?; Discussion; General discussion II; J.W. Lance: The neurovascular basis of migraine: some concluding thoughts; Index.
Series: Oxford Medical Publications
Number Of Pages: 336
Published: 8th March 1990
Country of Publication: GB
Dimensions (cm): 24.13 x 16.2
Weight (kg): 0.72