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Microspheres and Regional Cancer Therapy - Neville Wilmott

Microspheres and Regional Cancer Therapy

Hardcover Published: 1st January 1994
ISBN: 9780849369520
Number Of Pages: 245

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Microspheres and Regional Cancer Therapy takes an interdisciplinary approach to the subject of microspheres and regional cancer therapy. It synthesizes laboratory and clinical data to demonstrate the utility of microsphere-based strategies in the treatment of localized solid tumors (particularly in the liver) not amenable to surgery and as a component of strategies for treatment of disseminated disease. Using the same techniques that show the deficiencies of delivery strategies involving antibodies, liposomes, and synthetic polymers, clear evidence is presented describing how microspheres of appropriate size can be localized in solid tumor deposits in the liver with little exposure to other organs. To exploit this phenomenon, the extent and nature of the incorporation of active agents within microspheres is discussed in relation to release, pharmacokinetics, and tumor response achieved by intensification of therapy in the manner described. This book will benefit laboratory-based scientists and clinicians in pharmaceutics, pharmacology, physiology, surgical oncology, and nuclear medicine. In addition, cancer clinicians interested in the value of regional therapy will be able to evaluate the underlying theory and learn the necessary methodology.

Pharmaceutical and Methodological Aspects of Microparticlesp. 1
Blood Flow and its Modulation in Malignant Tumorsp. 31
Microparticulate Carriers as a Therapeutic Option in Regional Cancer Therapy: Clinical Considerationsp. 57
Magnetically Controlled Targeted Chemotherapyp. 71
Agents for Microsphere Incorporation: Physicochemical Considerations and Physiological Consequences of Particle Embolizationp. 117
Drug Analysis of Protein Microspheres: From Pharmaceutical Preparation to In Vivo Fatep. 141
Regional Therapy of Liver Metastases: A Surgeon's Viewp. 167
Evaluation of the Potential of Microspherical Systems for Regional Therapy in the Tumor-Bearing Liver and Kidney Using Techniques in Nuclear Medicinep. 197
Perspective on Microspheres in Regional Cancer Therapyp. 229
Indexp. 237
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780849369520
ISBN-10: 0849369525
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 245
Published: 1st January 1994
Publisher: CRC PR INC
Country of Publication: US
Dimensions (cm): 23.88 x 16.26  x 1.52
Weight (kg): 0.64
Edition Number: 1