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Microbial Reagents in Organic Synthesis : NATO SCIENCE SERIES SERIES C: MATHEMATICAL AND PHYSICAL SCIENCES - Stefano Servi

Microbial Reagents in Organic Synthesis


By: Stefano Servi (Editor)

Hardcover Published: 30th September 1992
ISBN: 9780792319535
Number Of Pages: 490

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Different aspects of biocatalysis are discussed with a view to obtaining products in a practical way using microorganisms and enzymes in catalytic amounts but as if they were organic reagents. A limited number of reactions catalysed by microbial reagents have been examinded according to the following classes: C-C bond formation, including the reaction catalyzed by aldolases, enantiomeric oxynitrilases, and decarboxylases. Oxidations promoted by microorganisms leading to Bayer-Williger-type products and hydroxylation at saturated carbon also includes the production of synthons derived from the microbial oxidation of substituted aromatics of wide synthetic applications. Reductions of carbonyl group with yeasts and other microorganisms, including the factor affecting the stereoselectivity when using all-cell organisms.
Group transfer reactions describes synthetic achievements and theoretical aspects concerning the use of lipases, esterases and acylases. Industrial applications of microbial reagents in the large-scale production of fine chemicals offers validation to the basic research in the field.

Cyclase mediated synthesis of terpenoidsp. 3
(R)- and (S)-Cyanohydrins - Their enzymatic synthesis and their reactionsp. 25
Chemical-enzymatic synthesis of carbohydratesp. 35
A building block strategy for asymmetric synthesis: the DHAP-aldolasesp. 43
Transferase catalyzed synthesis: applications in series of aminoacids and monosaccharidesp. 57
Acyloin formation mediated by benzoylformate decarboxylasesp. 67
Organic synthesis via biocatalytic methods - A chemoenzymatic approach to the synthesis of FK506p. 79
Use of enzymes as catalysts in key reactions leading to the synthesis of optically active natural products and analoguesp. 93
New enzymatic methods for the selective functionalization of carbohydrate derivativesp. 113
Efficient synthesis of optically active carbohydrates and other oxygenated compounds through bio-oxidation of chlorinated aromaticsp. 123
Chemoenzymatic synthesis of natural products and bioactive compoundsp. 135
Biotransformations applied to the synthesis of vitamins and pharmaceuticalsp. 149
A direct route from hydantoins to D-amino acids employing a resting cell biocatalyst with D-hydantoinase and D-carbamoylase activityp. 161
The use of immobilized penicillin G acylase in organic synthesisp. 175
Are proteases suitable tools for the formation of peptide bonds?p. 189
Enzymatic aminolysis, hydrazinolysis and oximolysis reactionsp. 199
Microbial and enzymatic transformation of nitrilesp. 209
Resolution of racemates with lipases and effect of reaction conditions on enantioselectivityp. 225
Selectivity enhancement of Candida cylindracea lipase: covalent enzyme modification and control of micro-pHp. 239
Lipase catalyzed organic synthesisp. 249
Kinetics and validation of mathematical models of enantioselective transesterification in organic solventsp. 261
Enzymatic enantioselective ester hydrolysis by carboxylesterase NPp. 273
A kinetic interpretation of acids and alcohols influence on the enantioselectivity in enzyme catalysed resolutionsp. 289
Asymmetrized tris(hydroxymethyl)methane and related synthons as new highly versatile chiral building blocks. Chemoenzymatic preparation and synthetic applicationsp. 299
A comparative study of chemical versus biological functionalizations of synthetic intermediatesp. 313
Enantioselective sulfoxidations catalyzed by chloroperoxidase and horseradish peroxidasep. 323
Use of biooxygenation in fine organic synthesisp. 333
The enzymatic Baeyer-Villiger oxidationp. 347
Beauveria Sulfurescens mediated oxidation of dihydroartemisin derivatesp. 361
Comparison of chemical and biochemical reduction methods for the synthesis of (R)-2-hydroxy-4-phenylbutyric acidp. 377
Stereochemical control in microbial reductionp. 389
Approaches to 2-methyl-1-alkanols of high enantiomeric purities via enzyme mediated reactionsp. 399
Microbial alcohol/aldehyde oxidoreductases in enantioselective conversionsp. 411
Stereocontrolled reduction of [beta]-ketoesters with Geotrichum candidump. 421
Useful enzymes from plant cell and organ culturesp. 441
List of Contributorsp. 455
List of Participantsp. 459
Subject Indexp. 465
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792319535
ISBN-10: 0792319532
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 490
Published: 30th September 1992
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 24.13 x 16.51  x 3.18
Weight (kg): 1.0