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Microbial Genomes : Infectious Disease - Claire M. Fraser

Microbial Genomes

Infectious Disease

By: Claire M. Fraser (Editor), Timothy Read (Editor), Karen E. Nelson (Editor)

Hardcover

Published: 9th April 2004
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  • Paperback View Product Published: 9th December 2010
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This collection of diverse articles by the pioneers of modern genomics takes stock of the current state of the field and elucidates the contribution that sequencing genomes has made to our understanding of microbial metabolism and evolution. Through twenty-eight thought-provoking chapters, the authors describe some of the most common computational methods and their applications to studying pathogenic microorganisms, show how genomics can be used to reconstruct the history and dynamism of the microbial world, and discuss issues as diverse as reconstruction of metabolic pathways, cell cycle processes, microbial evolution, metagenomics, and vaccine development. Additional chapters deal with microarrays and expression analysis and the role of genomic in drug discovery.

Forewordp. v
Prefacep. vii
Contributorsp. xiii
Introduction
History of Microbial Genomicsp. 3
Bioinformatics As a Tool in Genomics
Tools for Gene Finding and Whole Genome Comparisonp. 19
Bacterial Genome Annotation at TIGRp. 33
Bioinformatics and Microbial Pathogenesisp. 47
Bacteriophage Bioinformaticsp. 71
Core Functions
Comparative Microbial Metabolismp. 95
Genomic Analysis of Membrane Transportp. 113
Genomics-Based Analysis of the Bacterial Cell Cyclep. 127
The Evolution of Microbial Genomes
A Brief History of Views of Prokaryotic Evolution and Taxonomyp. 143
How Bacterial Genomes Changep. 155
Concepts of Bacterial Biodiversity for the Age of Genomicsp. 175
Coevolution of Symbionts and Pathogens With Their Hostsp. 195
A Survey of Microbial Genomes
A Survey of Plant Pathogen Genomesp. 213
Anoxygenic Phototrophic Bacteriap. 225
Genomics of Thermophilesp. 245
The Genomes of Pathogenic Enterobacteriap. 269
Obligate Intracellular Pathogensp. 291
Low G+C Gram-Positive Genomesp. 309
Genomics of Actinobacteria, the High G+C Gram-Positive Bacteriap. 333
Parasite Genomicsp. 361
Genome Sequence of an Extremely Halophilic Archaeonp. 383
Applications of Genomic Data
Microarrays, Expression Analysis, and Bacterial Genomesp. 403
Microbial Population Genomics and Ecology: A New Frontierp. 419
Application of Genomics to Biocatalysis and Biodegradationp. 443
Enzyme Discovery and Microbial Genomicsp. 461
Integration of Genomics in the Drug Discovery Processp. 485
A Genomic Approach to Vaccine Developmentp. 505
Microbial Proteomicsp. 517
Indexp. 531
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9781588291899
ISBN-10: 1588291898
Series: Infectious Disease
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 536
Published: 9th April 2004
Publisher: Humana Press Inc.
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 3.18
Weight (kg): 1.35