Real-time in vitro measurement of Intrinsic and Ras GAP-mediated GTP hydrolysis | |
Schwann cell preparation from single mouse embryos: Analyses of neurofibromin function in Schwann cells | |
Regulation of the nucleotide state of oncogenic Ras proteins by nucleoside diphosphate kinase | |
Measurements of TSC2 GAP activity toward Rheb | |
Characterization of AND-34 function and signalling | |
Studying the spatial and temporal regulation of Ras GTPase-activating proteins | |
Activation of Ras Proteins by Ras Guanine Nucleotide Releasing Protein Family Members | |
Ras and Rap1 Activation of PLC? lipase activity | |
Specificity and expression of RalGPS as RalGEFs | |
Biochemical and biological analyses of Rgr RalGEF oncogene | |
Analysis of Ras Activation in Living Cells with GFP-RBD | |
Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function | |
Characterization of the activation of the Rap specific exchange factor epac by cyclic nucleotides | |
Biochemistry of the Rap-specific guanine nucleotide exchange factors PDZ-GEF1 and 2 | |
Characterization of interactions between Ras family GTPases and their effectors | |
Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis | |
Sequencing analysis of BRAF mutations in human cancers | |
KSR regulation of the Raf-MEK-ERK cascade | |
Ras-sensitive IMP modulation of the Raf/MEK/ERK cascade through KSR1 | |
Raf Kinase Inhibitor Protein (RKIP) regulation of Raf and MAPK signalling | |
Harnessing RNAi for Analyses of Ras Signaling and Transformation | |
The Rac Activator Tiam1and Ras induced Oncogenesis | |
Phospholipase Ce C+ guanine nucleotide exchange factor activity and activation of Rap1 | |
Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases | |
RASSF family proteins and Ras transformation | |
Ras and the Rain/RasBP1 effector | |
The RIN family of Ras effectors | |
RAP1 regulation of RIAM and cell adhesion | |
Regulation of cell-cell adhesion by Rap1 | |
Effects of Ras signaling on gene expression analyzed by customized microrays | |
Protein-fragment complementation assays (PCA) in small GTPase research and drug discovery | |
Ras Up-regulation of Cycloxygenase-2 | |
Regulation of the expression of tropomyosins and actin cytoskeleton by ras-transformation | |
Regulation of Par-4 by Oncogenic Ras | |
Using Drosophila and yeast genetics to investigate a role for the RhebGTPase in cell growth | |
Biochemistry and Biology of ARHI (DIRAS3), An Imprinted Tumor Suppressor Gene Whose Expression Is Lost In Ovarian and Breast Cancer | |
Gem protein signaling and regulation | |
Analysis of Rem/RGK Signaling and Biological Activity | |
Analysis of Rit Signaling and Biological Activity | |
Characterization of RERG: An estrogen-regulated tumor suppressor gene | |
Inhibition of transcription factor NF-?B activation by ?B-Ras | |
Analysis of Rhes activation state and effector function | |
Rheb activation of mTOR and S6K1 signaling | |
Use of Retrovirus Expression of Interfering RNA to Determine the Contribution of Activated K-Ras and Ras Effector Expression to Human Tumor Cell Growth | |
Using inhibitors of prenylation to block localization and transforming activity | |
Sorafenib (BAY 43-9006), a dual action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature | |
Yeast screens for inhibitors of Ras-Raf interaction and characterization of MCP inhibitors of Ras-Raf interaction | |
A tagging-via-substrate technology for genome-wide detection and identification of farnesylated proteins | |
A genetically defined normal human somatic cell system to study Ras oncogenesis in vivo and in vitro | |
Analyses of Ras transformation of human thyroid epithelial cells | |
Use of Ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer | |
Physiological analysis of oncogenesic Kras | |
Use of conditionally active Ras Fusion Proteins to study Epidermal Growth, Differentiation and Neoplasia | |
Pancreatic duct epithelial cell isolation and cultivation in two dimensional and three dimensiona | |
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