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Methods for Investigating Localized Clustering of Disease : International Agency for Research on Cancer Scientific Publications - F.E. Alexander

Methods for Investigating Localized Clustering of Disease

International Agency for Research on Cancer Scientific Publications

By: F.E. Alexander (Editor), P. Boyle (Editor)

Paperback Published: February 1997
ISBN: 9789283221357
Number Of Pages: 276

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Methods for investigating generalized spatial clustering of disease in human populations have only recently become available. This volume presents the outcome of a unique practical test of these methods, in which authors of several newly-developed approaches conducted their own blind analyses of over 50 artificial datasets, some random, some generated by clustering processes. Results were then compared with the known spatial structure. An historical view of leukaemia clustering is also included. This book will be of particular interest to epidemiologists and public health specialists with responsibility for analysing childhood leukaemia and other rare diseases for which the phenomenon of clustering may offer important clues to aetiology. It will also be useful for statisticians with an interest in analysis of spatial distributions of rare disease.

Foreword
Introduction
Historical aspects of leukaemia clusters
The simulated data -sets
Analysing the spatial distribution of disease using a method of constructing geographical areas of approximately equal population size
Testing for over-dispersion using an adapted form of the Potthoff-Whittinghill method
Clustering methods based on k nearest neighbour distributions
Using a geographical analysis machine to detect the presence of spatial clustering and the location of clusters in synthetic data
The detection of small-area database anomalies
Detailed results for selected data-sets, All participants
Overview of results, All participants
Editorial comments
Responses by individual authors to editorial comments, Individual investigators Appendices
The data-sets, All investigators
Extension of the ISD method
Cuzick-Edwards one-sample and inverse two-sampling statistics
Tests of clustering based on pattern-recognition procedures
Second-order analysis of spatial clustering
A scan statistic for detecting spatial clusters
The CAS method
Geostatistics for determining the risk of rare disease
References
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9789283221357
ISBN-10: 9283221354
Series: International Agency for Research on Cancer Scientific Publications
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 276
Published: February 1997
Publisher: International Agency for Research on Cancer
Country of Publication: FR
Dimensions (cm): 25.4 x 17.8  x 1.4
Weight (kg): 0.48