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Metals and Oxidative Damage in Neurological Disorders - James R. Connor

Metals and Oxidative Damage in Neurological Disorders

By: James R. Connor (Editor)

Hardcover Published: 30th September 1997
ISBN: 9780306455346
Number Of Pages: 374

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The purpose of this book is to bring together scientists and clinicians interested in oxidative injury in the nervous system but whose approaches to investigation and treatment design vary widely. Indeed the goal of this book is to show that the investiga- tive approaches and potential therapeutic interventions perhaps do not vary as widely as some may think. I think that the readers of this book will not read it from front to back, but will pick chapters of interest. Thus, the chapters are organized to contain information that is essential to understanding basic aspects of oxidative injury, and thus have some redundancy. However, within the context of each chapter the reader should hopefully find impetus and direction to go on to another chapter. The book is divided into three seetions. The first section contains reviews of metals and their role in generating oxidative injury. lron is considered in three of these chapters because of its relative abundance in the brain and its potency in inducing free radicals. The second section focuses on mechanisms by which the brain attempts to protect itself from oxidative injury. Some of these mechanisms have the potential to be protective in some situations and potentiaIly damaging in others. The third section contains the clinicaI diseases in which oxidative injury is known to contribute to the pathogenic process. This seetion ends with a chapter on antioxidant therapeutic strate- gies in neurological disorders.

Evidence for Iron Mismanagement in the Brain in Neurological Disorders
Iron and Neurotransmitter Function in the Brain
Magnetic Resonance Imaging of Brain Iron
Neurochemical Roles of Copper as Antioxidant or Prooxidant
Manganese Neurotoxicity and Oxidative Damage
The Role of Zinc in Brain and Nerve Functions
Delivery of Metals to Brain and the Role of the Blood-Brain Barrier
Ferritin: Intracellular Regulator of Metal Availability
Ascorbate: An Antioxidant Neuroprotectant and Extracellular Neuromodulator
Vitamin E: Neurochemical Aspects and Relevance to Nervous System Disorders
Nitric Oxide and Oxidative Damage in the CNS
Iron and Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury: Directions for Therapeutic Intervention
The Role of Oxidative Processes and Metal Ions in Aging and Alzheimer's Disease
Perspectives on the Mechanisms of Familial Amyotrophic Lateral Sclerosis Caused by Mutations in Superoxide Dismutase
3 Additional Chapters
Appendix
Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780306455346
ISBN-10: 030645534X
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 374
Published: 30th September 1997
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 2.39
Weight (kg): 1.64