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Metal Ions in Biological Systems : Volume 30: Metalloenzymes Involving Amino Acid-residue and Related Radicals - Helmut Sigel

Metal Ions in Biological Systems

Volume 30: Metalloenzymes Involving Amino Acid-residue and Related Radicals

By: Helmut Sigel (Editor), Astrid Sigel (Editor)

Hardcover Published: 1st February 1994
ISBN: 9780824790936
Number Of Pages: 494

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Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Volume 21 describes the underlying theories of nuclear magnetic resonance (NMR), promoting a wider use of NMR in studies of paramagnetic species. In six concise chapters by leading international authorities, Applications of Nuclear Magnetic Resonance to Paramagnetic Species outlines the most recent developments regarding the use of nuclear relaxation as a source for structural information ... examines studies of magnetically coupled metalloproteins and metal-porphyrin induced dipolar shifts for conformational analysis ... and evaluates the potential of paramagnetic ions as agents for enhancing NMR image contrast. With over 500 references that facilitate further research, Applications of Nuclear Magnetic Resonance to Paramagnetic Species is an essential resource for scientists and students in such disciplines as biophysics; bioinorganic, inorganic, and coordination chemistry; biochemistry; molecular biology; and enzymology. Book jacket.

." . .an excellent review of the current understanding of metalloproteins and free radicals in biological systems. . .well written. . .This book should be on the shelf of those interested in metalloproteins." ---INFORM

Preface to the Seriesp. iii
Preface to Volume 30p. v
Contributorsp. xiii
Contents of Previous Volumesp. xv
Handbook on Toxicity of Inorganic Compoundsp. xxxii
Handbook on Metals in Clinical and Analytical Chemistryp. xxxiii
Free Radicals and Metalloenzymes: General Considerationsp. 1
Introduction: A Survey of Biologically Relevant Free Radicalsp. 2
Necessity of Free Radicals and Metal Ionsp. 4
Reactivities of Free Radicalsp. 7
Summary of Free Radical-Dependent Metalloenzymesp. 11
Abbreviationsp. 21
Referencesp. 22
Peroxidases: Structure, Function, and Engineeringp. 25
Introductionp. 26
Peroxidase Crystal Structuresp. 30
Peroxidase Catalytic Mechanismsp. 48
Peroxidase Engineeringp. 56
Conclusionsp. 65
Abbreviationsp. 66
Referencesp. 67
Photosystem IIp. 77
Introductionp. 78
Identification and Spectroscopic Studies of the Tyrosine Radicalsp. 83
Electron Transfer Reactions of the Tyrosine Radicals--Both O[subscript 2]-Evolving and Inhibited Photosystem IIp. 89
Other Radicals in Photosystem IIp. 95
Concluding Remarksp. 99
Abbreviationsp. 100
Referencesp. 100
Ribonucleotide Reductase in Mammalian Systemsp. 109
Introductionp. 110
Mammalian Ribonucleotide Reductasep. 110
Herpes Simplex Virus Ribonucleotide Reductasep. 115
Comparison of Amino Acid Sequences and Spectroscopic Properties for Different Speciesp. 116
Formation, Properties, and Stability of the Fe-Tyrosyl Radical Centerp. 120
Inhibitors; Radical Scavengers; Iron Chelators; Specific Peptidesp. 121
Subunit Interaction and Electron Transferp. 124
Abbreviationsp. 125
Referencesp. 125
Manganese-Dependent Ribonucleotide Reduction and Overproduction of Nucleotides in Coryneform Bacteriap. 131
Introduction: The Diversity of Ribonucleotide Reductase Systemsp. 132
Effects of Manganese Depletion in Coryneform Bacteriap. 136
The Manganese-Containing Ribonucleotide Reductase of Brevibacterium ammoniagenesp. 142
Distribution of Manganese Ribonucleotide Reductasesp. 153
Concluding Remarks--Ribonucleotide Reduction: Universal but Not Uniformp. 156
Abbreviationsp. 158
Referencesp. 158
Prostaglandin Endoperoxide Synthasesp. 163
Introductionp. 164
PGH Synthase Isozymesp. 167
Cyclooxygenase Catalysisp. 171
Peroxidase Catalysisp. 179
Cyclooxygenase-Peroxidase Interrelationshipsp. 184
PGH Synthase Structurep. 186
Abbreviationsp. 192
Referencesp. 192
Diol Dehydrase from Clostridium Glycolicum: The Non-B[subscript 12]-Dependent Enzymep. 201
Introductionp. 202
Diol Metabolism in C. glycolicump. 203
Properties of Membrane bound Diol Dehydrase from C. glycolicump. 206
Characterization of Diol Dehydrasep. 209
Conclusionsp. 213
Abbreviationsp. 214
Referencesp. 214
Diol Dehydrase and Glycerol Dehydrase, Coenzyme B[subscript 12]-Dependent Isozymesp. 217
Introductionp. 218
Purification, Properties, and Structuresp. 219
Catalytic Properties and Mechanism of Actionp. 223
Formation of Free Radicalsp. 232
Inactivation and Reactivationp. 240
Physiological Rolesp. 244
Concluding Remarksp. 247
Abbreviationsp. 248
Referencesp. 249
Adenosylcobalamin (Vitamin B[subscript 12] Coenzyme)-Dependent Enzymesp. 255
Survey of Adenosylcobalamin-Dependent Enzymesp. 256
Mechanisms of the Co-C Bond Cleavagep. 259
Mechanisms of the Subsequent Reactionsp. 269
Conclusionp. 275
Abbreviationsp. 275
Referencesp. 276
S-Adenosylmethionine-Dependent Radical Formation in Anaerobic Systemsp. 279
Introductionp. 280
Pyruvate Formate Lyase-Activating Enzymep. 280
Lysine 2,3-Aminomutasep. 300
Anaerobic Ribonucleotide Reductasep. 306
Concluding Remarksp. 308
Abbreviationsp. 309
Referencesp. 309
The Free Radical-Coupled Copper Active Site of Galactose Oxidasep. 315
Introductionp. 316
Historical Surveyp. 318
Recent Developmentsp. 322
Model Reactions and the Role of the Radical in Catalysisp. 352
Abbreviations and Definitionsp. 356
Referencesp. 356
Amine Oxidasesp. 361
Introductionp. 362
Structural Properties of Amine Oxidasesp. 365
Catalytic Mechanism of Amine Oxidasesp. 380
Biological Roles of Amine Oxidasesp. 392
Conclusions and Prospectsp. 395
Abbreviationsp. 396
Referencesp. 397
Bacterial Transport of and Resistance to Copperp. 405
Introductionp. 406
Copper in Bacterial Nutritionp. 407
Copper Transport and Uptakep. 409
Bacterial Systems Conferring Resistance to Excess Copperp. 415
Concluding Remarksp. 428
Definitions and Abbreviationsp. 429
Referencesp. 430
Author Indexp. 435
Subject Indexp. 469
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780824790936
ISBN-10: 0824790936
Series: Metal Ions in Biological Systems : Book 30
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 494
Published: 1st February 1994
Publisher: TAYLOR & FRANCIS
Country of Publication: US
Dimensions (cm): 23.47 x 15.34  x 2.9
Weight (kg): 0.89
Edition Number: 1