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Metal Ions in Biological Systems : Volume 23: Nickel and its Role in Biology - Helmut Sigel

Metal Ions in Biological Systems

Volume 23: Nickel and its Role in Biology

By: Helmut Sigel (Editor), Astrid Sigel (Editor)

Hardcover Published: 1st March 1988
ISBN: 9780824777135
Number Of Pages: 488

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Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Volume 21 describes the underlying theories of nuclear magnetic resonance (NMR), promoting a wider use of NMR in studies of paramagnetic species. In six concise chapters by leading international authorities, Applications of Nuclear Magnetic Resonance to Paramagnetic Species outlines the most recent developments regarding the use of nuclear relaxation as a source for structural information ... examines studies of magnetically coupled metalloproteins and metal-porphyrin induced dipolar shifts for conformational analysis ... and evaluates the potential of paramagnetic ions as agents for enhancing NMR image contrast. With over 500 references that facilitate further research, Applications of Nuclear Magnetic Resonance to Paramagnetic Species is an essential resource for scientists and students in such disciplines as biophysics; bioinorganic, inorganic, and coordination chemistry; biochemistry; molecular biology; and enzymology. Book jacket.

Preface to the Seriesp. iii
Preface to Volume 23p. v
Contributorsp. xiii
Contents of Other Volumesp. xv
Handbook on Toxicity of Inorganic Compoundsp. xxix
Nickel in the Natural Environmentp. 1
General Chemistry and Geochemistry of Nickelp. 2
Nickel in the Lithosphere and in Nickel Depositsp. 5
Nickel in the Pedospherep. 10
Nickel in the Hydrospherep. 13
Nickel in the Atmospherep. 17
Nickel in the Biosphere and Its Degradation Productsp. 17
General Summaryp. 25
Referencesp. 25
Nickel in Aquatic Systemsp. 31
Introductionp. 32
Nickel as an Essential Element for Aquatic Biotap. 32
Nickel Toxicityp. 33
Partitioning and Chemical Forms of Nickel in Waterp. 39
Bioaccumulation of Nickel by Aquatic Biotap. 40
Food Chain Transfer of Nickelp. 43
Conclusions and Recommendationsp. 43
Referencesp. 44
Nickel and Plantsp. 47
Nickel--An Essential Element for Plants?p. 48
Nickel Toxicityp. 52
Nickel Uptake and Nickel Content of Plants: Background Levelsp. 59
Nickel Uptake and Soil Parametersp. 60
Nickel Uptake and Pollutionp. 63
Nickel Tolerancep. 67
Nickel-Accumulating Plantsp. 70
Phytochemistry of Nickel-Accumulating Plantsp. 77
Future Outlookp. 81
Referencesp. 82
Nickel Metabolism in Man and Animalsp. 91
Introductionp. 92
Routes of Nickel Absorptionp. 92
Distribution of Nickelp. 96
Nickel Transport and Cellular Uptakep. 99
Nickel Biochemistryp. 103
Routes of Eliminationp. 107
Nickel as an Essential Elementp. 109
Concluding Remarks and Summaryp. 114
Abbreviationsp. 115
Referencesp. 116
Nickel Ion Binding to Amino Acids and Peptidesp. 123
The Settingp. 124
Amino Acid Complexesp. 126
Citrate Complexesp. 142
Peptide Complexesp. 143
Referencesp. 159
Nickel in Proteins and Enzymesp. 165
Introductionp. 167
Nickel in Biologyp. 168
Nickel-Binding Proteinsp. 172
Enzymes and Metal Ionsp. 179
Metal Ion Catalysisp. 186
Some Properties of Nickel Complexesp. 196
Nickel(II) Catalysis in Model Systemsp. 216
Nickel(II)-Activated Enzymesp. 219
Binding Sites for Metal Ionsp. 231
Nickel(III) Enzymesp. 243
Nickel(II) Metalloenzymes: Ureasep. 256
Conclusionp. 263
Referencesp. 263
Nickel-Containing Hydrogenasesp. 285
Introductionp. 286
Nickel Involvement in Hydrogenasesp. 287
Spectroscopic Tools and Instrumental Probes: Isotopic Substitutionsp. 287
Active Center Composition: Types of Hydrogenasesp. 289
Cell Localization of Hydrogenases: Existence of Multiple Forms and Genetic Informationp. 291
EPR and Mossbauer Studies: Nickel and [FeS] Centersp. 292
Midpoint Redox Potentialsp. 301
Nickel Site Coordinationp. 302
Discussion of a Mechanistic Framework for the Nickel-Containing Hydrogenasesp. 303
Conclusionp. 309
Abstractp. 309
Note Added in Proofp. 310
Referencesp. 311
Nickel Ion Binding to Nucleosides and Nucleotidesp. 315
Binding to Bases and Nucleosidesp. 316
Binding to Nucleotidesp. 321
Referencesp. 328
Interactions between Nickel and DNA: Considerations about the Role of Nickel in Carcinogenesisp. 331
Introductionp. 332
Nickel(II) Interaction with DNAp. 335
Nickel and Nucleoproteinsp. 346
In Vivo Influence of Nickel(II) on the Thermal Properties of Chromatin Inside the Nuclei, and on Cells and Tissues of Normal and Tumorous Originp. 348
Nickel(II) Incorporation in DNA and the Role of Nickel in Carcinogenesisp. 352
Conclusionp. 354
Referencesp. 356
Toxicology of Nickel Compoundsp. 359
Introductionp. 360
Human Exposuresp. 361
Nickel Carbonyl Poisoningp. 363
Nickel Hypersensitivityp. 367
Nickel Carcinogenesisp. 373
Genetic Toxicologyp. 379
Miscellaneous Health Effectsp. 386
Concluding Remarks and Summaryp. 390
Abbreviationsp. 392
Referencesp. 392
Analysis of Nickel in Biological Materialsp. 403
General Aspects of Analyses of Nickel in Biological Materialsp. 403
Choice of Implements and Chemicalsp. 405
Specimen Collection; Samplingp. 407
Sample Preparationp. 413
Determination Methodsp. 418
Abbreviationsp. 425
Referencesp. 426
Author Indexp. 429
Subject Indexp. 463
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780824777135
ISBN-10: 0824777131
Series: Metal Ions in Biological Systems : Book 23
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 488
Published: 1st March 1988
Country of Publication: US
Dimensions (cm): 23.27 x 15.29  x 2.85
Weight (kg): 0.87
Edition Number: 1

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