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Metal Ions in Biological Systems : Metal Ions in Biological Systems Antibiotics and Their Complexes Vol. 19 - Helmut Sigel

Metal Ions in Biological Systems

Metal Ions in Biological Systems Antibiotics and Their Complexes Vol. 19

By: Helmut Sigel (Editor)

Hardcover Published: 1st January 1985
ISBN: 9780824774257
Number Of Pages: 429

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Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Volume 21 describes the underlying theories of nuclear magnetic resonance (NMR), promoting a wider use of NMR in studies of paramagnetic species. In six concise chapters by leading international authorities, Applications of Nuclear Magnetic Resonance to Paramagnetic Species outlines the most recent developments regarding the use of nuclear relaxation as a source for structural information ... examines studies of magnetically coupled metalloproteins and metal-porphyrin induced dipolar shifts for conformational analysis ... and evaluates the potential of paramagnetic ions as agents for enhancing NMR image contrast. With over 500 references that facilitate further research, Applications of Nuclear Magnetic Resonance to Paramagnetic Species is an essential resource for scientists and students in such disciplines as biophysics; bioinorganic, inorganic, and coordination chemistry; biochemistry; molecular biology; and enzymology. Book jacket.

Preface to the Seriesp. iii
Preface to Volume 19p. v
Contributorsp. xiii
Contents of Other Volumesp. xv
The Discovery of Ionophores: An Historical Accountp. 1
Abbreviationsp. 16
Referencesp. 17
Tetracyclines and Daunorubicinp. 19
Introductionp. 19
Tetracyclinesp. 20
Daunorubicinp. 40
Referencesp. 49
Interaction of Metal Ions with Streptonigrin and Biological Properties of the Complexesp. 53
Introductionp. 54
Structural and Chemical Properties of Streptonigrin and Its Metal Complexesp. 55
Biological Activity and Suggested Mechanistic Schemes for the Antitumor Action of Streptonigrinp. 70
Conclusionsp. 76
Referencesp. 77
Bleomycin Antibiotics: Metal Complexes and Their Biological Actionp. 81
Introductionp. 82
Structural and Synthetic Aspects of Bleomycinp. 82
Characteristics of Bleomycin-Metal Complexesp. 85
Oxygen Activation and Redox Cycle of the Bleomycin-Iron Complexp. 85
Interaction of Bleomycin and Its Iron Complex with DNAp. 90
Sequence-Specific DNA Cleavage by the Bleomycin-Iron Complexp. 92
Metal Complexes and DNA Cleavage of Bleomycin Analogs: Peplomycin, Tallysomycin, and Phleomycinp. 95
Metal Complexes and Oxygen Activation by Synthetic Analogs and Biosynthetic Intermediates of Bleomycinp. 97
Molecular Mechanism of Bleomycin Actionp. 103
Conclusionsp. 104
Referencesp. 105
Interaction Between Valinomycin and Metal Ionsp. 109
Introductionp. 110
Structure and Conformation of Free Valinomycinp. 112
Structure and Conformation of Valinomycin-Metal Ion Complexesp. 115
Valinomycin-Metal Ion Complexes in Transmembrane Ion Transportp. 131
Abbreviations and Definitionsp. 132
Referencesp. 133
Beauvericin and the Other Enniatinsp. 139
Introductionp. 140
Ion Bindingp. 143
Membrane Transportp. 158
Analogsp. 165
Conclusionsp. 167
Abbreviationsp. 167
Referencesp. 168
Complexing Properties of Gramicidinsp. 173
Introductionp. 174
Structural Propertiesp. 175
Ion-Complexing Propertiesp. 186
Transport Propertiesp. 193
Referencesp. 200
Nactins: Their Complexes and Biological Propertiesp. 207
Introductionp. 207
Molecular Structure of Nactinsp. 209
Complexesp. 212
Biological Propertiesp. 224
Referencesp. 225
Cation Complexes of the Monovalent and Polyvalent Carboxylic Ionophores: Lasalocid (X-537A), Monensin, A23187 (Calcimycin), and Related Antibioticsp. 229
Introductionp. 230
Structure of Ionophore-Cation Inclusion Complexesp. 233
Techniques for Measuring Equilibrium Ionophore-Ion Affinitiesp. 239
Carboxylic Ionophore-Mediated Ion Transportp. 248
Biological Test Systemsp. 266
Conformational Aspects of Ion Capture and Membrane Transportp. 272
Biological Applications of Ionophoresp. 284
Overviewp. 288
Referencesp. 289
Complexes of D-Cycloserine and Related Amino Acids with Antibiotic Propertiesp. 295
Introductionp. 295
Mode of Actionp. 297
Uses of D-Cycloserinep. 298
Organic Chemistry of D-Cycloserinep. 300
Metal Ion Coordination by D-Cycloserinep. 301
Metal Ion Coordination by D-Cycloserine Derivativesp. 307
Conclusionsp. 308
Abbreviationsp. 309
Referencesp. 310
Iron-Containing Antibioticsp. 313
Introductionp. 314
Iron(III) Complexesp. 320
Iron(II) Complexesp. 324
Miscellaneous Compoundsp. 327
General Conclusionsp. 329
Referencesp. 330
Cation-Ionophore Interactions: Quantification of the Factors Underlying Selective Complexation by Means of Theoretical Computationsp. 335
Introductionp. 336
Outline of the Methodologyp. 337
Selective Binding of Alkali Cations by Valinomycinp. 342
Selective Complexation of K[superscript +], Na[superscript +], and NH[superscript + subscript 4] by Nonactinp. 347
Selective Binding of Mg[superscript 2+] and Ca[superscript 2+] by Ionophore A23187p. 354
Structural Properties of Valinomycin and A23187p. 364
Energy Profiles for Single and Double Occupancy by Na[superscript +] of the Gramicidin A Channelp. 374
Conclusionsp. 379
Abbreviationsp. 380
Referencesp. 381
Author Indexp. 387
Subject Indexp. 411
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780824774257
ISBN-10: 0824774256
Series: Metal Ions in Biological Systems : Book 19
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 429
Published: 1st January 1985
Country of Publication: US
Dimensions (cm): 23.57 x 15.14  x 2.69
Weight (kg): 0.79
Edition Number: 1

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