| Preface to the Series | p. iii |
| Preface to Volume 23 | p. v |
| Contributors | p. xiii |
| Contents of Other Volumes | p. xv |
| Handbook on Toxicity of Inorganic Compounds | p. xxix |
| Nickel in the Natural Environment | p. 1 |
| General Chemistry and Geochemistry of Nickel | p. 2 |
| Nickel in the Lithosphere and in Nickel Deposits | p. 5 |
| Nickel in the Pedosphere | p. 10 |
| Nickel in the Hydrosphere | p. 13 |
| Nickel in the Atmosphere | p. 17 |
| Nickel in the Biosphere and Its Degradation Products | p. 17 |
| General Summary | p. 25 |
| References | p. 25 |
| Nickel in Aquatic Systems | p. 31 |
| Introduction | p. 32 |
| Nickel as an Essential Element for Aquatic Biota | p. 32 |
| Nickel Toxicity | p. 33 |
| Partitioning and Chemical Forms of Nickel in Water | p. 39 |
| Bioaccumulation of Nickel by Aquatic Biota | p. 40 |
| Food Chain Transfer of Nickel | p. 43 |
| Conclusions and Recommendations | p. 43 |
| References | p. 44 |
| Nickel and Plants | p. 47 |
| Nickel--An Essential Element for Plants? | p. 48 |
| Nickel Toxicity | p. 52 |
| Nickel Uptake and Nickel Content of Plants: Background Levels | p. 59 |
| Nickel Uptake and Soil Parameters | p. 60 |
| Nickel Uptake and Pollution | p. 63 |
| Nickel Tolerance | p. 67 |
| Nickel-Accumulating Plants | p. 70 |
| Phytochemistry of Nickel-Accumulating Plants | p. 77 |
| Future Outlook | p. 81 |
| References | p. 82 |
| Nickel Metabolism in Man and Animals | p. 91 |
| Introduction | p. 92 |
| Routes of Nickel Absorption | p. 92 |
| Distribution of Nickel | p. 96 |
| Nickel Transport and Cellular Uptake | p. 99 |
| Nickel Biochemistry | p. 103 |
| Routes of Elimination | p. 107 |
| Nickel as an Essential Element | p. 109 |
| Concluding Remarks and Summary | p. 114 |
| Abbreviations | p. 115 |
| References | p. 116 |
| Nickel Ion Binding to Amino Acids and Peptides | p. 123 |
| The Setting | p. 124 |
| Amino Acid Complexes | p. 126 |
| Citrate Complexes | p. 142 |
| Peptide Complexes | p. 143 |
| References | p. 159 |
| Nickel in Proteins and Enzymes | p. 165 |
| Introduction | p. 167 |
| Nickel in Biology | p. 168 |
| Nickel-Binding Proteins | p. 172 |
| Enzymes and Metal Ions | p. 179 |
| Metal Ion Catalysis | p. 186 |
| Some Properties of Nickel Complexes | p. 196 |
| Nickel(II) Catalysis in Model Systems | p. 216 |
| Nickel(II)-Activated Enzymes | p. 219 |
| Binding Sites for Metal Ions | p. 231 |
| Nickel(III) Enzymes | p. 243 |
| Nickel(II) Metalloenzymes: Urease | p. 256 |
| Conclusion | p. 263 |
| References | p. 263 |
| Nickel-Containing Hydrogenases | p. 285 |
| Introduction | p. 286 |
| Nickel Involvement in Hydrogenases | p. 287 |
| Spectroscopic Tools and Instrumental Probes: Isotopic Substitutions | p. 287 |
| Active Center Composition: Types of Hydrogenases | p. 289 |
| Cell Localization of Hydrogenases: Existence of Multiple Forms and Genetic Information | p. 291 |
| EPR and Mossbauer Studies: Nickel and [FeS] Centers | p. 292 |
| Midpoint Redox Potentials | p. 301 |
| Nickel Site Coordination | p. 302 |
| Discussion of a Mechanistic Framework for the Nickel-Containing Hydrogenases | p. 303 |
| Conclusion | p. 309 |
| Abstract | p. 309 |
| Note Added in Proof | p. 310 |
| References | p. 311 |
| Nickel Ion Binding to Nucleosides and Nucleotides | p. 315 |
| Binding to Bases and Nucleosides | p. 316 |
| Binding to Nucleotides | p. 321 |
| References | p. 328 |
| Interactions between Nickel and DNA: Considerations about the Role of Nickel in Carcinogenesis | p. 331 |
| Introduction | p. 332 |
| Nickel(II) Interaction with DNA | p. 335 |
| Nickel and Nucleoproteins | p. 346 |
| In Vivo Influence of Nickel(II) on the Thermal Properties of Chromatin Inside the Nuclei, and on Cells and Tissues of Normal and Tumorous Origin | p. 348 |
| Nickel(II) Incorporation in DNA and the Role of Nickel in Carcinogenesis | p. 352 |
| Conclusion | p. 354 |
| References | p. 356 |
| Toxicology of Nickel Compounds | p. 359 |
| Introduction | p. 360 |
| Human Exposures | p. 361 |
| Nickel Carbonyl Poisoning | p. 363 |
| Nickel Hypersensitivity | p. 367 |
| Nickel Carcinogenesis | p. 373 |
| Genetic Toxicology | p. 379 |
| Miscellaneous Health Effects | p. 386 |
| Concluding Remarks and Summary | p. 390 |
| Abbreviations | p. 392 |
| References | p. 392 |
| Analysis of Nickel in Biological Materials | p. 403 |
| General Aspects of Analyses of Nickel in Biological Materials | p. 403 |
| Choice of Implements and Chemicals | p. 405 |
| Specimen Collection; Sampling | p. 407 |
| Sample Preparation | p. 413 |
| Determination Methods | p. 418 |
| Abbreviations | p. 425 |
| References | p. 426 |
| Author Index | p. 429 |
| Subject Index | p. 463 |
| Table of Contents provided by Ingram. All Rights Reserved. |
