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Metal Ions in Biological Systems : Metal Ions in Biological Systems Concepts on Metal Ion Toxicity Volume 20 - Helmut Sigel

Metal Ions in Biological Systems

Metal Ions in Biological Systems Concepts on Metal Ion Toxicity Volume 20

By: Helmut Sigel (Editor)

Hardcover Published: 21st February 1986
ISBN: 9780824775407
Number Of Pages: 416

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Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Volume 21 describes the underlying theories of nuclear magnetic resonance (NMR), promoting a wider use of NMR in studies of paramagnetic species. In six concise chapters by leading international authorities, Applications of Nuclear Magnetic Resonance to Paramagnetic Species outlines the most recent developments regarding the use of nuclear relaxation as a source for structural information ... examines studies of magnetically coupled metalloproteins and metal-porphyrin induced dipolar shifts for conformational analysis ... and evaluates the potential of paramagnetic ions as agents for enhancing NMR image contrast. With over 500 references that facilitate further research, Applications of Nuclear Magnetic Resonance to Paramagnetic Species is an essential resource for scientists and students in such disciplines as biophysics; bioinorganic, inorganic, and coordination chemistry; biochemistry; molecular biology; and enzymology. Book jacket.

Preface to the Seriesp. iii
Preface to Volume 20p. v
Contributorsp. xi
Contents of Other Volumesp. xiii
Distribution of Potentially Hazardous Trace Metalsp. 1
Introductionp. 1
Distribution of Trace Metals in the Atmosphere, Hydrosphere, and Lithospherep. 9
Metal Enrichment and Transferp. 14
Referencesp. 19
Bioinorganic Chemistry of Metal Ion Toxicityp. 21
Introductionp. 22
Essentiality and Toxicityp. 23
Properties of Metal Ionsp. 27
Survey of Metal Ionsp. 39
Caveatp. 61
Referencesp. 62
The Interrelation Between Essentiality and Toxicity of Metals in the Aquatic Ecosystemp. 67
General Introductionp. 68
Essential Metalsp. 69
Uptake and Incorporation of Metalsp. 76
Toxicity as a Result of Oversupply of Essential Metalsp. 78
Tolerance to Metalsp. 85
Effect of Essential Metals on Aquatic Communitiesp. 87
Conclusions and Outlookp. 95
Referencesp. 96
Metal Ion Speciation and Toxicity in Aquatic Systemsp. 101
Introductionp. 101
Chemical Modelp. 102
Application to Copper Toxicityp. 106
Application to Cadmium Toxicityp. 111
Application to Lead Toxicityp. 112
Application to Zinc Toxicityp. 114
Conclusionp. 115
Abbreviations and Definitionsp. 116
Referencesp. 116
Metal Toxicity to Agricultural Cropsp. 119
Introductionp. 120
Cadmiump. 121
Copperp. 134
Zincp. 139
Manganesep. 144
Nickelp. 147
Referencesp. 149
Metal Ion Toxicity in Man and Animalsp. 157
Introductionp. 158
Leadp. 159
Arsenicp. 167
Vanadiump. 171
Mercuryp. 173
Cadmiump. 177
Nickelp. 182
Chromiump. 186
Uraniump. 190
Conclusionsp. 193
Referencesp. 194
Human Nutrition and Metal Ion Toxicityp. 201
Introductionp. 202
Nutrient Intake and Nutritional Status in the United Statesp. 202
Seleniump. 204
Zincp. 214
General Conclusionsp. 222
Referencesp. 222
Chromosome Damage in Individuals Exposed to Heavy Metalsp. 229
Introductionp. 230
Production of Cytogenetic Changes in Peripheral Blood Lymphocytesp. 230
Results of the Cytogenetic Monitoring Performed on Persons Exposed to Heavy Metalsp. 237
General Discussionp. 248
Conclusionsp. 251
Referencesp. 252
Metal Ion Carcinogenesis: Mechanistic Aspectsp. 259
Introductionp. 260
Cellular Uptake and Intracellular Distribution of Metal Ionsp. 261
DNA Lesions Produced by Carcinogenic Metalsp. 271
Effect of Metal Ions on Cell Growth, DNA Replication, and DNA Repairp. 273
Tumor-Promoting Activity of Metals and the Relationship between Mutagenesis and Carcinogenesisp. 275
Inhibition of Transformation and Carcinogenesis by Divalent Metal Ionsp. 275
Referencesp. 276
Methods for the in Vitro Assessment of Metal Ion Toxicityp. 279
Introductionp. 280
Biochemical Methodsp. 283
Microbiological Methodsp. 285
Mammalian Cell Culture Methodsp. 287
General Conclusionsp. 296
Referencesp. 297
Some Problems Encountered in the Analysis of Biological Materials for Toxic Trace Elementsp. 305
General Aspects of Trace Element Analysisp. 305
Choice of Implements and Chemicalsp. 308
Specimen Collectionp. 311
Storage, Drying, and Homogenizationp. 319
Sample Aliquotation and Samplingp. 322
Sample Preparationp. 323
Referencesp. 334
Author Indexp. 337
Subject Indexp. 361
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780824775407
ISBN-10: 0824775406
Series: METAL IONS IN BIOLOGICAL SYSTEMS : Book 20
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 416
Published: 21st February 1986
Publisher: Taylor & Francis Inc
Country of Publication: US
Dimensions (cm): 24.13 x 16.51  x 2.54
Weight (kg): 0.7
Edition Number: 1

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