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Membrane Proteins: Structures, Interactions and Models : Proceedings of the Twenty-Fifth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, May 18-21,1992 - A. Pullman

Membrane Proteins: Structures, Interactions and Models

Proceedings of the Twenty-Fifth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, May 18-21,1992

By: A. Pullman (Editor), Joshua Jortner (Editor)

Hardcover Published: 31st October 1992
ISBN: 9780792319511
Number Of Pages: 506

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The main theme of the symposium reported in this book was the presentation and discussion of the direct and indirect evidence available on the three-dimensional structure of membrane proteins and on the interactions relevant to their functioning. Among the topics discussed are the lessons of the known 3D structures, the prospects in 3D structure determination (by X-rays, electron microscopy, neutron scattering, NMR, optical methods, site-directed mutagenesis, theoretical calculations and modeling, etc) and the interactions with lipids. The originality of the Symposium, reflected in the content of the book, was to bring together well-known specialists in the biochemistry of the proteins considered (bacteriorhodopsin, receptors, acetylcholine esterase, glycophorine, porines, etc) and experts in the physicochemical, chemical and theoretical methods utilized.

Preface
Electron Crystallography of Membrane Proteinsp. 1
High-Resolution Electron Microscopy of Membrane Proteinsp. 11
Distinguishing Transmembrane Helices from Peripheral Helices by Circular Dichroismp. 17
High-Resolution NMR of Membrane Proteins: the Example of Bacteriorhodopsinp. 39
Molecular Dynamics Simulations of Bacteriorhodopsinp. 47
Dynamics of Bacteriorhodopsin Studied by Neutron Scattering : Effects of the Environment, Softness and Structurep. 61
What do Neutrons, X-Ray Synchrotron Radiation, Optical pH-Indicators, and Mutagenesis tell us about the Light-Driven Proton Pump Bacteriorhodopsin?p. 69
From Time-Resolved Difference Spectra to Kinetics, Mechanism, and Thermodynamics in the Bacteriorhodopsin Photocyclep. 85
Arginine 175 is Part of an Anion Binding Site in Bacteriorhodopsinp. 97
Electrostatic Calculations of the pKa's of Ionizable Groups in Bacteriorhodopsinp. 107
Dimerization of Glycophorin A Transmembrane Helices: Mutagenesis and Modelingp. 115
The Nicotinic Acetylcholine Receptor, a Model of Ligand-Gated Ion Channels: Investigation of its Functional Organization by Protein Chemistry and Site-Directed Mutagenesisp. 127
Molecular Evolution of the Binding Site of the Nicotinic Acetylcholine Receptorp. 147
3-D Structure of Acetylcholinesterase and Complexes of it with Anticholinesterase Agentsp. 161
Modelling and Mutagenesis of Butyrylcholinesterase Based on the X-Ray Structure of Acetylcholinesterasep. 177
The Nicotinic Acetylcholine Receptor and its Lipid Microenvironmentp. 185
A Correlation Between Patch Clamp and Fluorescence Anisotropy Experiments to Study Alterations on the Acethylcholine Channel Induced by Cholesterol Enrichment in Chick Myocytesp. 199
Interaction of the Nicotinic Acetylcholine Receptor with Ligands and Membrane Lipids Studied by Fourier-Transform Infrared Spectroscopy and Photoaffinity Labelingp. 213
On the Complexation of the Methylammonium Ion by Aromatic Side Chains of Proteinsp. 229
The Inhibitory Glycine Receptor: Structure-Function Studies on a Neuronal Chloride Channelp. 233
Determinants of Ligand Binding to the Inhibitory Glycine Receptorp. 241
Channel Proteins: from Anatomy to Designp. 249
Linking Permeation Behavior and Structure of Ion Channels with a Microscopic Modelp. 269
Molecular Structure-Function Relations in Voltage-Gated Ion Channels of Excitable Membranesp. 279
A Novel Model for Saturation of Ion Conductivity in Transmembrane Channelsp. 297
Computational Approaches to Understanding the Ion Channel-Lipid Systemp. 315
A Minimal Model of Ion Channels: Polyamino Acids in Liposomesp. 339
Structure and Dynamics of Melittin in Solution and Membranes from Amide Hydrogen Exchange Analysisp. 357
Computer Modelling of Ion Binding Sites in Proteinsp. 367
Sec-Dependent and Sec-Independent Mechanisms of Protein Insertion into Bacterial Membranesp. 383
Puncturing Cell Membranes: Comparison of Colicin A and Aerolysinp. 393
Structure-Function Relationships in the Membrane Channel Porin as Based on a 1.8 A Resolution Crystal Structurep. 403
Molecular Mechanism of Action of Pore-Forming Colicins and of their Immunity Proteinsp. 413
Preliminary Structural Studies of Photosystem 1p. 427
Problems and Progress in Computational Approaches to the Molecular Basis of Recognitionp. 443
Assembly of Escherichia Coli Inner Membrane Proteins: Sec-Dependent and Sec-Independent Membrane Insertionp. 449
Molecular Dynamics Simulations of Phospholipid Membranes and their Interaction with Phospholipasep. 457
Electron Transfer in Bacterial Photosynthetic Reaction Centersp. 471
Proton Transfer Pathways in Photosynthetic Reaction Centers Studied by Site-Directed Mutagenesisp. 481
Indexp. 497
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792319511
ISBN-10: 0792319516
Series: Jerusalem Symposia
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 506
Published: 31st October 1992
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 3.3
Weight (kg): 1.03

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