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Membrane Permeability : 100 Years Since Ernest Overton: Volume 48 - Dale J. Benos

Membrane Permeability

100 Years Since Ernest Overton: Volume 48

By: Dale J. Benos (Editor), David W. Deamer (Editor), Arnost Kleinzeller (Editor), Douglas M. Fambrough (Editor)

Hardcover Published: 1st January 1999
ISBN: 9780121533489
Number Of Pages: 423

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Membrane permeability is fundamental to all cell biology and subcellular biology. The cell exists as a closed unit. Import and export depend upon a number of sophisticated mechanisms, such as active transport, endocytosis, exocytosis, and passive diffusion. These systems are critical for the normal housekeeping physiological functions. However, access to the cell is also taken advantage of by toxic microbes (such as cholera or ptomaine) and when designing drugs.
Ernest Overton, one of the pioneers in lipid membrane research, put forward the first comprehensive theory of lipid membrane structure. His most quoted paper on the osmotic properties of cells laid the foundation for the modern concepts of membrane function, most notably important in anesthesia.
This book is designed to celebrate the centennial anniversary (in the first chapter) of Overton's work. Subsequent chapters present readers with up-to-date concepts of membrane structure and function and the challenge they pose for new explorations.
Key Features
* Provides an historical perspective of Overton's contributions to the theory of narcosis
* Presents an overview of each permeability mechanism, including active transport, endocytosis, exocytosis, and passive diffusion

Overton's Concept of a Cell Membrane
T.J. McIntosh, Structure and the Physical Properties of the Lipid Membrane
Insights from Computer Simulations into the Interactions of Small Molecules with Lipid Bilayers
The Permeability Barriers to Ions and Polar Solutes
Water Permeation Across Membranes
Membrane Events Involved in Volume Regulation
The Interaction of Natural and Model Peptides with Membranes
Lipid-Peptide Diffusion in Membranes
A Short History of Ion Channels and Signal Propagation
The Lipid Membrane and Ligand-Gated Ion Channels in General Anesthetic Action
Plasma Membrane-Localized Signal Transduction
Active Transport and Pumps
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780121533489
ISBN-10: 0121533484
Series: Current Topics in Membranes : Book 48
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 423
Published: 1st January 1999
Country of Publication: US
Dimensions (cm): 23.55 x 15.67  x 2.46
Weight (kg): 0.67