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Mechanisms of Organ Dysfunction in Critical Illness : Update in Intensive Care and Emergency Medicine - Timothy W. Evans

Mechanisms of Organ Dysfunction in Critical Illness

Update in Intensive Care and Emergency Medicine

By: Timothy W. Evans (Editor), Mitchel P. Fink (Editor)

Hardcover

Published: 28th August 2001
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The pathophysiology of sepsis can be regarded as a series of steps, beginning with the invasion of normally sterile tissue by microbes and the elaboration of various pro-inflammatory mediators. The final common pathway is often the development of the multiple organ dysfunction syndrome (MODS). Whereas a great deal has been learned during the past quarter century about the inflammatory processes associated with sepsis (and other related conditions, such as ischemia/reperfusion injury), our understanding is far less developed with respect to the pathophysiological events that lead to organ dysfunction under these conditions. Nevertheless, efforts by both clinical and laboratory scientists are leading to new knowledge in this area. The chapters in this volume provide a state-of-the-art overview of many aspects of the pathophysiology of organ dysfunction in critical illness.

Cellular Responses to Hypoxia: Role of Oxidant Signal Transductionp. 3
The Mitochondrial Permeability Transition: A 'Pore' Way to Diep. 17
Cytopathic Hypoxia in Circulatory Shock: The Role of Poly (ADP-Ribose) Synthetase Activationp. 40
Derangements in Cellular Oxygen Metabolismp. 52
Pharmacologic and Metabolic Mitochondrial Rescuep. 69
Role of Leukocytes in Sepsis and Lung Injuryp. 95
Dysregulated Neutrophil Apoptosis in the Pathogenesis of Organ Injury in Critical Illnessp. 110
Does Apoptosis Play a Role in the Development of Sepsis-Induced Myocardial Dysfunction?p. 124
The Intracellular Signaling Pathways of Inflammatory Stressp. 137
Pro-Inflammatory Cytokines: Double-Edged Swords in the Pathogenesis of Bacterial Infectionp. 146
Organ-Organ Interactions in Multiple Organ Failurep. 159
Endothelial Cell Dysfunction and Abnormal Tissue Perfusionp. 175
The Microcirculation in Sepsisp. 191
Pulmonary Vascular Dysfunctionp. 205
Pulmonary Epithelial Injury: Clinical and Experimental Evidence for a Major Role in Acute Lung Injury and Multiple Organ Dysfunctionp. 222
Ischemia-Induced Derangements in the Actin Cytoskeleton: Mechanisms and Functional Significancep. 227
Multiple Organ Failure and the Kidneyp. 239
Apoptosis in Renal Ischemia-Reperfusion Injuryp. 253
Local Muscularis Inflammatory Mechanisms of Ileusp. 267
Mechanisms Responsible for Intestinal Barrier Dysfunction in Critical Illnessp. 282
Liver Dysfunction: Nitric Oxide, Carbon Monoxide, and Reactive Oxygen Speciesp. 301
Polyamine Oxidase and 3-Aminopropanal in the Pathogenesis of Cerebral Ischemiap. 315
Key Mechanisms of Secondary Neuronal Damage After Brain Traumap. 327
Cerebral Ischemia: Pathophysiology and Neuroprotectionp. 339
Redistribution of Microvascular Oxygen Pressures in the Pig Intestine in Hemodilution and Sepsisp. 351
Influence of Mechanical Ventilation on Organ Dysfunctionp. 363
Coagulation Abnormalities in Critical Illnessp. 376
Multiple Organ Failure: Clinical Syndromep. 394
Subject Indexp. 405
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540421931
ISBN-10: 3540421939
Series: Update in Intensive Care and Emergency Medicine
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 410
Published: 28th August 2001
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 0.81