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Mechanisms of Lymphocyte Activation and Immune Regulation V : Molecular Basis of Signal Transduction - Sudhir Gupta

Mechanisms of Lymphocyte Activation and Immune Regulation V

Molecular Basis of Signal Transduction

By: Sudhir Gupta (Editor)

Hardcover Published: 31st October 1994
ISBN: 9780306448973
Number Of Pages: 264

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Signaling through antigen receptor initiates a complex series of events resulting in the activation of genes that regulate the development, proliferation and differentiation of lymphocytes. During the past few years, rapid progress has been made in understanding the molecular basis of signaling pathways mediated by antigen and cytokine receptors. These pathways involve protein tyrosine kinases which are coupled to downstream regulatory molecules, including small guanine nucleotide binding proteins (e. g. p21'OS), serine threonine kinases (e. g. , members of the ERK family), and a large group of transcription factors. More recently, there have been breakthroughs in elucidating the genetic defects underlying three X-linked primary immunodeficiency diseases in humans. This volume surveys aspects of these rapidly developing areas of research. The book is divided into 5 different sections. Section I deals with signaling pathways in B lymphocytes. It includes a contemporary assessment of B cell antigen receptor structures, and discussion of the role of Ig-a/lg-B polypeptides in linking the antigen receptor to intracellular signal transduction pathways. The role of accessory molecules in the regulation of signaling by the B cell antigen receptor is also considered. Section II adopts a similar approach to the analysis of the antigen receptor on T lymphocytes. The importance of specialized signaling motifs in the CD3 polypeptides, mechanisms whereby these motifs may interact with the lymphocyte-specific protein tyrosine kinases, and the downstream consequences of these interactions are reviewed. In addition, the role of antigen-induced apoptosis in the generation of immunological tolerance is discussed.

Signaling and Internalisation Function of the B Cell Antigen Receptor Complexp. 1
Mechanism of B Cell Antigen Receptor Function: Transmembrane Signaling and Triggering of Apoptosisp. 9
B-Cell Activation by Wild Type and Mutant Ig-[beta] Cytoplasmic Domainsp. 23
Accessory Molecules Which Influence Signaling Through B Lymphocyte Antigen Receptorsp. 35
Analysis of the (YXXL/I)2 Signalling Motifs Found in the Cytoplasmic Segment of the Mouse CD3[zeta] Chainp. 45
Molecular and Genetic Insights Into T Cell Antigen Receptor Signal Transductionp. 53
Signal Transduction During T Cell Developmentp. 63
The Regulation and Function of p21Ras in Signal Transduction by the T Cell Antigen Receptorp. 73
Immunological Tolerance by Antigen-Induced Apoptosis of Mature T Lymphocytesp. 81
Properties of Ca Currents Activated by T Cell Receptor Signalingp. 91
The Role of Syk in Cell Signalingp. 103
Nonreceptor Tyrosine Kinases in Aggregation-Mediated Cell Activationp. 111
Control of Lymphopoiesis by Non-Receptor Protein Tyrosine Kinasesp. 121
Involvement of Nonreceptor Protein Tyrosine Kinases in Multichain Immune Recognition Receptor Signal Transductionp. 131
Phorbol Myristate Acetate-Induced Changes in Protein Kinase C Isozymes ([alpha], [beta], and [zeta]) in Human T Cell Subsetsp. 143
Specific CD45 Isoforms Regulate T Cell Ontogeny and Are Functionally Distinct in Modifying Immune Activationp. 149
Cloning and Characterization of NF-AT[subscript c] and NF-AT[subscript p]: The Cytoplasmic Components of NF-ATp. 167
Quantitative Aspects of Receptor Aggregationp. 175
Fc Receptor Signalingp. 185
Proximal Signals and the Control of S-Phase Entry in Interleukin-2-Stimulated T Lymphocytesp. 197
The IL-4 Receptor - Signaling Mechanismsp. 211
Function of the Common [beta] Subunit of the GM-CSF/IL-3/IL-5 Receptorsp. 217
Sharing of a Common [gamma] Chain, [actual symbol not reproducible] by the IL-2, IL-4, and IL-7 Receptors: Implications for X-Linked Severe Combined Immunodeficiencyp. 225
X-Linked Agammaglobulinemia and Bruton's Tyrosine Kinasep. 233
The Role of CD40 Ligand in Human Diseasep. 239
Involvement of the Protein Tyrosine Phosphatase PTP1C in Cellular Physiology, Autoimmunity and Oncogenesisp. 245
Contributorsp. 255
Indexp. 257
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306448973
ISBN-10: 0306448971
Series: Advances in Experimental Medicine and Biology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 264
Published: 31st October 1994
Country of Publication: US
Dimensions (cm): 25.4 x 17.78  x 1.75
Weight (kg): 0.7

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