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Mechanisms of Intracellular Trafficking and Processing of Proproteins - Y.Peng Loh

Mechanisms of Intracellular Trafficking and Processing of Proproteins

Hardcover Published: 1st January 1993
ISBN: 9780849368707
Number Of Pages: 297

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Mechanisms of Intracellular Trafficking and Processing of ProProteins provides an in-depth discussion of the cellular organization and current views of the molecular mechanisms underlying the trafficking, sorting, and processing of various classes of proproteins. The book covers the mechanisms of pro-protein translocation across the rough endoplasmic reticulum (RER) membrane and subsequent transport to the Golgi apparatus, molecular sorting and retention signals involved in directing pro-proteins to various cellular compartments, and the specific enzymes mediating different posttranslational modification steps. It is the only book that covers the principles of intracellular trafficking and processing of proproteins using examples representative of different classes of proproteins in the cell. New classes of enzymes, especially proteases with unique specificities, are examined as well.
Mechanisms of Intracellular Trafficking and Processing of ProProteins presents a wealth of information valuable to cell biologists, endocrinologists, neurobiologists, enzymologists, and biochemists. Students studying molecular endocrinology, neurobiology, and cell biology will also find the book to be a useful text.

Intracellular Protein Trafficking and Proprotein Processing: An Overviewp. 1
Intracellular Trafficking of Pre-(Pro) Proteins Across RER Membranesp. 19
Protein Transport from the Endoplasmic Reticulum to the Golgi Apparatusp. 79
Posttranslational Processing and Intracellular Transport of Newly Synthesized Lysosomal Enzymesp. 103
Prohormone Processing: The Role of Propeptides in Intracellular Sorting, Precursor Processing, and Secretionp. 131
Secretory Granule Formationp. 157
Proteolytic Processing of Prohormones and Pro-Neuropeptidesp. 179
Endoproteolysis of Growth Factors and Other Nonendocrine Precursor Proteinsp. 225
Processing of Pro-Peptides: Glycosylation, Phosphorylation, Sulfation, Acetylation, and Amidationp. 251
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780849368707
ISBN-10: 0849368707
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 297
Published: 1st January 1993
Publisher: CRC PR INC
Country of Publication: US
Dimensions (cm): 23.88 x 16.26  x 2.29
Weight (kg): 0.64
Edition Number: 1

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