Mechanisms of Cancer Metastasis : Potential Therapeutic Implications

1. The Cancer Problem Today.- 2. Present Status and Future Prospects for Treatment of Metastatic Cancer.- 3. A Critical Overview of the Metastatic Process.- 4. Experimental Models for Studying the Pathogenesis and Therapy of Metastatic Disease.- 5. Problems Posed for Cancer Treatment by Tumor Cell Heterogeneity.- 6. Multidrug Resistance and Metastasis.- 7. Polyamine Biosynthesis: A Target for Antimetastatic Therapy.- 8. Chemical Mechanisms of Modulation of Tumor Growth and Metastasis by Prostaglandins.- 9. Platelet-Tumor Cell Interactions as a Target for Antimetastatic Therapy.- 10. Mechanisms of Inhibition of Cancer Dissemination by Warfarin.- 11. Cancer Cell Procoagulants and Their Possible Role in Metastasis.- 12. Role of Growth Stimulatory Factors in Determining the Sites of Metastasis.- 13. Interleukins, Lymphokines and Lymphoid Neoplasia.- 14. The Use of Activated Macrophages for the Destruction of Heterogeneous Metastasis.- 15. Biological Response Modifiers as Activators of Natural Killer Cells: Potential Role in Treatment of Metastasis.- 16. Breast Cancer Diagnosis with Human Mammary Epithelial Antigens and the Prospective Use of Antibodies Against Them in Therapy.- 17. Chemotaxis in Tumor Cells: Possible Mechanisms and Their Implications for Therapy.- 18. Invasion of Vascular Endothelium and Organ Tissue in Vitro by B16 Melanoma Variants.- 19. Domains of Laminin and Basement Membrane Collagen which Play a Role in Metastases.- 20. Interaction of Malignant Cells with Substrata: Adhesion, Degradation and Migration.- 21. Proteolytic Enzymes in Tumor Invasion and Degradation of Host Extracellular Matrices.- 22. Cathepsin B-Like Cysteine Proteinases and Metastasis.- 23. Applications for Antimetastatic Therapies.