Mechanisms and Mediators of Neuropathic Pain

By: Annika B. Malmberg (Editor), Sandra R. Chaplan (Editor)

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Hardcover | 1 April 2002

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Hardcover
276 Pages

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24.13 x 17.15 x 2.54

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Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initiates a cascade of events resulting in altered neurochemistry and molecular biology of the peripheral neurons, the dorsal root ganglion cell, and changes in neurotransmitter and receptor expression in the dorsal horn of the spinal cord. Moreover, nerve injury produces anatomical changes with functional consequences. This volume summarises the current understanding of the pathophysiological processes in the peripheral and central nervous system that contribute to the neuropathic pain. It provides a timely review of neuropathic pain mechanisms, written by experts in the field. The book focuses on peripheral consequences of nerve injury, spinal cord plasticity following peripheral nerve injury, preclinical and clinical paradigms, and new treatment strategies for neuropathic pain, including glutamate receptor antagonists, antiepileptic drugs and calcium channel antagonists. This book is a valuable source of information for scientists as well as for clinicians interested in the molecular machinery involved in nerve-injury induced pain states and possible ways of treatment.

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You Can Find This Book In

Non-Fiction Medicine Pre-Clinical Medicine & Basic Sciences Anatomy Science Biology, Life Sciences Life Sciences in General Neurosciences Physiology Other Branches of Medicine Pathology Clinical & Internal Medicine

Neurology & Clinical Neurophysiology Diseases & Disorders Immunology Anaesthetics Pain & Pain Management

List of contributors
Preface
Peripheral consequences of nerve injury
Electrophysiological characteristics of injured peripheral nerves	p. 3
Sodium channels and the molecular basis for pain	p. 23
Changes in DRG neurons after injury: possible involvement in the development and maintenance of neuropathic pain	p. 51
Neuroinflammation, cytokines and neuropathic pain	p. 67
Spinal cord plasticity following peripheral nerve injury
Pharmacological plasticity associated with neuropathic pain states	p. 79
Sprouting and reorganization in the spinal cord after nerve injury	p. 89
Neuropathic pain: preclinical and clinical paradigms
Pre-clinical nerve ligation models: behavior and electrophysiology	p. 109
Animal models of toxic and metabolic sensory neuropathies	p. 127
Role of adrenergic transmitters and receptors in nerve and tissue injury related pain	p. 153
Evaluation of neuropathic pain	p. 175
New treatment strategies for neuropathic pain
Glutamate receptor antagonists and neuropathic pain	p. 201
Antiepileptic drugs for treatment of neuropathic pain	p. 211
Calcium channel antagonists for the treatment of pain	p. 233
Cholinergic, adenosinergic and [alpha][subscript 2] adrenergic mechanisms in chronic neuropathic pain	p. 245
Index	p. 255
Table of Contents provided by Blackwell. All Rights Reserved.

Mechanisms and Mediators of Neuropathic Pain

At a Glance

Hardcover

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Defective items

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