| Preface | p. vii |
| Structure and Function of H,K-ATPase--Molecular Basis for Drug Targets | |
| The Gastric H,K-ATPase | p. 1 |
| Human Nongastric H,K-ATPase: Current View On Structure and Functional Properties | p. 19 |
| Functional Consequences of Subunit Interactions in Na,K- and H,K-ATPases | p. 33 |
| HKc[alpha] Encodes Ouabain-Insensitive H,K-ATPase in Surface Cells of Rat Distal Colon | p. 43 |
| Molecular Diversity and Regulatory Heterogeneity of H,K-ATPases in Kidney | p. 53 |
| Mutational Analysis of Gastric Proton Pump, [alpha]- and [beta]-Subunits | p. 59 |
| Structure-Activity Relationships of Na,K-ATPase and H,K-ATPase | p. 71 |
| The Effect of Mutations Within a Cluster of Homologous Amino Acids Present in the M5, M6 and M8 Transmembrane Regions of the H,K-ATPase | p. 83 |
| Helicobacter Pylori and Mucosal Protection | |
| Host-Specific H. pylori Inhibition of H,K-ATPase [alpha] Subunit Gene Expression | p. 91 |
| H[superscript +],K[superscript +]-ATPase, the Dominant Gastric Autoantigen In Helicobacter pylori Infection | p. 101 |
| The Gastric H/K ATPase in the Pathogenesis of Autoimmune Gastritis | p. 107 |
| Duodenal Protection: Influence of Melatonin and Other Intestinal Transmitters on Duodenal Bicarbonate Secretion and Enterocyte Signaling | p. 115 |
| Role of Cytokines in Helicobacter pylori-Induced Gastric Epithelial Cell Matrix Metalloproteinase Secretion and Activation | p. 123 |
| HCI Causes Less Intracellular Acidification in Surface Epithelial Cells of Isolated Necturus Gastric Mucosa than Other Inorganic Acids | p. 127 |
| Ethanol Increases Intracellular Free Calcium, Closes Gap Junctions and Decreases Cell Volume in Primary Cultured Rabbit Gastric Epithelial Cell Monolayers | p. 131 |
| Induction of Small Intestinal Damage by Inhibition of Both NO Synthase and COX-2 | p. 135 |
| Role of Protein Kinases on Acid-Induced Duodenal Bicarbonate Secretion in Rats | p. 139 |
| Acid Induces Duodenal Epithelial Acidification and HCO[subscript 3 superscript -] Secretion via Activation of the Na[superscript +]:HCO[subscript 3 superscript -] Cotransporter and CFTR in Mice | p. 143 |
| Gene Targeting Mouse--Mechanisms of Acid Secretion and Cell Proliferation | |
| Insights into the Cell Biology, Development and Pathology of the Gastric Mucosa Revealed in Gastric H/K ATPase and Gastrin-Deficient Mice | p. 147 |
| Genetically Engineered Animal Models: Physiological Studies with Gastrin in Transgenic Mice | p. 159 |
| Gastric Cytoprotection by Prostaglandin E[subscript 2]--Relation to EP Receptor Subtypes | p. 169 |
| Gastric Mucus Accumulation is Reduced in Helicobacter pylori Infected Transgenic Mice Expressing the Human [alpha]-1,3/4-Fucosyltransferase in Surface Epithelial Cells | p. 181 |
| Signal Transduction in the Parietal Cell--Pathway to Activation | |
| New Insights into Second Messenger Regulation of Parietal Cell Function by Novel Downstream Signaling Proteins | p. 185 |
| Functional Role of Protein Kinase B/Akt in Gastric Acid Secretion | p. 197 |
| Permeabilized Gastric Gland Models--A New Strategy for Analyzing Parietal Cell Signal Transduction | p. 209 |
| Parietal Cell Volume Regulation During Acid Secretion | p. 221 |
| Characterization, Regulation and Localization of the Gastric Cl[superscript -] Channel Associated with Gastric Acid Secretion | p. 233 |
| Identification of Potassium Channels Associated with H,K-ATPase in the Parietal Cell | p. 247 |
| Kir2.1 K[superscript +] Channels of the Gastric Parietal Cell | p. 255 |
| Kinetics of Activation of H[superscript +] Secretion by Secretagogues in Relation to Changes in [Ca[superscript 2+]i in Isolated Gastric Glands | p. 265 |
| Measurement of Intracellular Calcium and Gastric Acid Secretion in Real Time Using Fluorescent Probes | p. 275 |
| Tissue and Cell Distribution of Parchorin, a Chloride Intracellular Channel-Related Protein | p. 279 |
| Cytoskeleton and Membrane Trafficking--The Gastric Parietal Cell as a Model | |
| Scanning EM Studies of Gastric Oxyntic Cells with Special Reference to the Translocation of Tubulovesicular System towards the Intracellular Canaliculus | p. 283 |
| 3-Dimensional Modeling of the Gastric Parietal Cell | p. 295 |
| Pharmacological Control of Gastric Acid Secretion via the Apical Membrane of Parietal Cells in Dogs | p. 305 |
| The Cytoskeleton as a Modulator of Gastric Secretion | p. 317 |
| Clathrin and Associated Proteins on Tubulovesicles and Apical Membranes of Parietal Cells | p. 327 |
| Rab11 Interacting Proteins as Regulators of Parietal Cell Apical Recycling: Lessons from the Master | p. 335 |
| Regulation of Acid Secretion and Mucosal Permeability by F-actin in the Bullfrog Gastric Mucosa | p. 349 |
| Fluid Dynamics of the Excretory Flows of Zymogenic and Mucinous Contents in Rat Gastric Glands Processed by High Pressure Freezing/Freeze Substitution, with Special Reference to the Secretory Dynamics of Phospholipase A[subscript 2] And Phospholipase C[gamma]1 | p. 361 |
| Index | p. 365 |
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