| Contributors | p. xi |
| Preface | p. xiii |
| Regional Stress and Strain in Healthy and Diseased Ventricular Myocardium | |
| Introduction | p. 1 |
| Ventricular Geometry and Structure | p. 2 |
| Regional Myocardial Mechanics | p. 3 |
| Engineering Models of Wall Stress | p. 7 |
| Analyzing Wall Strain Distributions | p. 8 |
| Regional Strain Distributions in Disease | p. 9 |
| Future Directions | p. 10 |
| Acknowledgments | p. 11 |
| References for Chapter 1 | p. 11 |
| Clinical Applications of Cardiac Tagging | |
| Introduction | p. 17 |
| Imaging Techniques | p. 18 |
| Tagged Image Data Analysis | p. 19 |
| MR Tagging in Normal Human Heart | p. 22 |
| MR Tagging in Ischemic Heart Disease | p. 24 |
| MR Tagging in Left Ventricular Hypertrophy | p. 28 |
| Cardiomyopathies | p. 29 |
| Right Ventricular Mechanics | p. 30 |
| Pericardial Constriction | p. 30 |
| Summary | p. 30 |
| Acknowledgments | p. 31 |
| References for Chapter 2 | p. 31 |
| Finite Element Modeling for Three-Dimensional Motion Reconstruction and Analysis | |
| Introduction | p. 37 |
| The Finite Element Model | p. 38 |
| Basis Functions | p. 39 |
| Global Parameters | p. 40 |
| Coordinate Systems | p. 40 |
| Kinematics | p. 42 |
| Model Tags: 3D Formulation | p. 43 |
| Geometric Fits | p. 43 |
| Model Tag 3D Fitting | p. 44 |
| Image Analysis | p. 45 |
| Minimization | p. 46 |
| Reconstruction of RV Surface Deformation | p. 48 |
| RV Free wall geometry | p. 49 |
| Model Tags: Surface Formulation | p. 49 |
| Principal Component Analysis | p. 51 |
| Generating the Data Set | p. 53 |
| PCA of Normal Geometry and Deformation | p. 53 |
| Future Work | p. 55 |
| References for Chapter 3 | p. 56 |
| Modeling and analysis of the RV and LV from MRI-SPAMM | |
| Introduction | p. 59 |
| Biventricular Model Geometry | p. 61 |
| RV Contour Segmentation | p. 62 |
| Processing Contour Data | p. 62 |
| Finite element mesh generation | p. 64 |
| 3D RV and LV motion reconstruction | p. 64 |
| MRI Input Data | p. 65 |
| Model Dynamics | p. 65 |
| External Forces from SPAMM data | p. 67 |
| External forces From Contour Data | p. 69 |
| Internal Forces Due To Stiffness | p. 70 |
| Motion and Deformation Analysis | p. 72 |
| Motion Parameters | p. 72 |
| Data Analysis | p. 73 |
| Results | p. 74 |
| Model fitting behavior | p. 75 |
| Validation studies | p. 75 |
| Clinical Data | p. 79 |
| Discussion | p. 84 |
| Conclusions and Future Work | p. 85 |
| Acknowledgments | p. 85 |
| Appendix | p. 85 |
| Finite Element Shape Functions | p. 85 |
| Strain Calculation Using Finite Elements | p. 86 |
| References for Chapter 4 | p. 89 |
| Motion Analysis of the Whole Heart | |
| Motivation and Background | p. 91 |
| Introduction and Background | p. 92 |
| Anatomy and Physiology | p. 93 |
| Studying Right Ventricular and Atrial Dynamics | p. 94 |
| MR Imaging of Right Ventricular and Atrial Function | p. 95 |
| B-Spline based Motion Tracking | p. 97 |
| Methods | p. 98 |
| MR Imaging | p. 98 |
| Ventricular Motion Analysis | p. 100 |
| Atrial Surface Fitting | p. 101 |
| Calculation of the Atrial Motion Field | p. 103 |
| Results | p. 106 |
| Motion Analysis of Right and Left Ventricles | p. 106 |
| Motion Analysis of Atria | p. 108 |
| Discussion | p. 109 |
| Conclusion | p. 112 |
| Acknowledgments | p. 113 |
| References for Chapter 5 | p. 113 |
| Harmonic Phase MRI | |
| Introduction | p. 119 |
| A Harmonic Model of Tagged MR Images | p. 120 |
| HARP Motion Measurement Principles | p. 123 |
| Apparent Motion | p. 125 |
| Spatial and Temporal Derivatives | p. 126 |
| CINE-HARP (CHARP) Methods | p. 127 |
| Tracking Motion | p. 127 |
| Legrangian Strain | p. 130 |
| Velocity Fields | p. 134 |
| Strain-rate Maps | p. 137 |
| Single-shot HARP (SHARP) Methods | p. 139 |
| Tagline Synthesis | p. 139 |
| Radial and Circumferential Eulerian Strain | p. 140 |
| Minimum and Maximum Eulerian Strain | p. 142 |
| Contraction Angle | p. 145 |
| Combining CHARP and SHARP Methods | p. 146 |
| Summary and Conclusion | p. 146 |
| Acknowledgments | p. 148 |
| References for Chapter 6 | p. 149 |
| Automated Tag Detection | |
| Introduction | p. 151 |
| Signal Models | p. 152 |
| Tagged Myocardium | p. 153 |
| Untagged Tissue | p. 155 |
| Tag Center Estimation | p. 156 |
| Single Tag Center Estimation | p. 156 |
| Tag Line Estimation | p. 158 |
| Hypothesis Testing | p. 160 |
| Myocardium Detection | p. 161 |
| Tag Line Detection | p. 161 |
| Removal of False Tag Points | p. 162 |
| Algorithm Implementation | p. 163 |
| Black Blood Images | p. 163 |
| White Blood Images | p. 166 |
| In Vivo Experiments | p. 169 |
| Imaging Protocol | p. 169 |
| Black Blood Images | p. 169 |
| White Blood Images | p. 171 |
| Discussion | p. 171 |
| Acknowledgments | p. 177 |
| Appendix | p. 178 |
| Likelihood Function Derivative | p. 178 |
| References for Chapter 7 | p. 179 |
| Analysis of Tagged MR Cardiac Images with B-spline Models | |
| Introduction | p. 183 |
| B-spline basics | p. 186 |
| Definitions and Notations | p. 186 |
| Properties | p. 187 |
| Coupled B-snake Grids | p. 188 |
| Constrained Thin-Plate Spline Reconstruction | p. 190 |
| Solution Using Subspace Approximations | p. 193 |
| Validations | p. 196 |
| Myocardial Strains | p. 203 |
| Measurement of 3D Motion of Myocardial Beads | p. 204 |
| Imaging Protocol | p. 205 |
| Reconstruction of Tag Planes | p. 206 |
| Computing 3D Coordinates of Myocardial Beads | p. 207 |
| Validations | p. 213 |
| Conclusions | p. 214 |
| Acknowledgments | p. 215 |
| References for Chapter 8 | p. 215 |
| MR Physics and Imaging of Phase Contrast MRI | |
| Introduction | p. 219 |
| Basic Principles of Phase Contrast MRI | p. 220 |
| Flow and Motion Compensation | p. 221 |
| Velocity Encoding | p. 221 |
| Implementation issues | p. 223 |
| Gradient Echo imaging | p. 223 |
| Respiratory Motion | p. 224 |
| Segmented Scans | p. 225 |
| Black Blood Preparation | p. 225 |
| Measurement Timing and Pulse Sequence Design | p. 226 |
| Multi Echo Approaches | p. 228 |
| Measurement Timing | p. 230 |
| View Sharing Approaches | p. 231 |
| Data Processing | p. 232 |
| Results | p. 237 |
| Volunteers | p. 237 |
| Patients | p. 238 |
| Discussion | p. 243 |
| Appendix | p. 245 |
| Signal Phase | p. 245 |
| References for Chapter 9 | p. 246 |
| Myocardial Spatiotemporal Tracking | |
| Introduction | p. 257 |
| Imaging Cardiac Motion | p. 258 |
| Mapping Velocity With Phase Contrast MRI | p. 259 |
| Analyzing Motion | p. 262 |
| DMESH Motion/Strain Mapping | p. 264 |
| The Spatiotemporal Finite Element Model | p. 265 |
| The DMESH Tracking Algorithm | p. 267 |
| Reproducibility Analysis | p. 268 |
| Lagrangian Strain Field Computation | p. 269 |
| Extended Use of DMESH Tracking | p. 270 |
| Experiments | p. 271 |
| Computer simulation studies | p. 271 |
| In vitro and in vivo studies | p. 275 |
| Combined use of displacement and velocity data | p. 277 |
| Discussion | p. 280 |
| Acknowledgments | p. 282 |
| References for Chapter 10 | p. 283 |
| Computational Platforms for Integrated Cardiac Image Analysis | |
| Introduction | p. 289 |
| Obtaining Estimates of Cardiac Displacements | p. 290 |
| Methods Relying on Magnetic Resonance Tagging | p. 290 |
| Methods Relying on Phase Contrast MRI | p. 291 |
| Computer-Vision Based Methods | p. 292 |
| The Shape-Based Tracking Approach | p. 293 |
| Modeling used for Interpolation and Smoothing | p. 296 |
| The Strain Tensor | p. 297 |
| Material Models | p. 300 |
| A Bayesian Estimation Framework | p. 303 |
| Experimental Results | p. 305 |
| Pre and post-occlusion comparison | p. 306 |
| Shape-Based Estimates vs MR Tagging | p. 308 |
| Future Research Directions | p. 309 |
| Acknowledgments | p. 310 |
| References for Chapter 11 | p. 310 |
| Index | p. 315 |
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