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Maturation Phenomenon in Cerebral Ischemia V - A.M. Buchan

Maturation Phenomenon in Cerebral Ischemia V

By: A.M. Buchan (Editor), Umeo Ito (Editor), Fred Colbourne (Editor), Toshihiko Kuroiwa (Editor), Igor Klatzo (Editor)

Paperback Published: February 2004
ISBN: 9783540408741
Number Of Pages: 362

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The maturation phenomenon, first described by Ito et al. in 1975, refers to postischemic changes that develop hours or days after an ischemic insult. The delayed neuronal death of CA1 pyramidal cells of the hippocampus is a classic example. The report of the phenomenon boosted research in the field, as it became evident that ischemic damage is not a sudden event, but a process potentially susceptible to therapeutic intervention. Since then a growing number of studies have improved our knowledge on mechanisms of cell death and recovery. This volume contains the presentations of the Fifth International Workshop on Maturation Phenomenon in Cerebral Ischemia, held in Banff, Alberta, Canada, in April/May 2002. It outlines the present status of investigations and provides further stimulation for research in this field.

Role of Genetic Expression and Neuronal Apoptosis and/or Necrosis
Modulation of Neuronal Death by the Transcription Factor E2F1 in Experimental Strokep. 1
Brain Genomic Responses to Ischemic Stroke, Hemorrhage, Seizures, Hypoglycemia and Hypoxiap. 13
Temporal Profile of Gene Induction After Venous Ischemia and Effects of Spreading Depressionp. 37
The Role of Protein Phosphatases Type 2C in Neuronal Apoptosisp. 43
Mitochondrial Cytochrome C- and Smac-Dependent Apoptosis in Cerebral Ischemia: Role of Oxidative Signalingp. 53
Erythropoietin: A Beneficial Approach to Neuroprotection in Strokep. 63
Transgenic Mutants for the Investigation of Molecular Stroke Mechanismsp. 65
Ischemic Infarction: Inflammation
Compartmentalization in Focal Cerebral Ischemiap. 81
Modulation of the Post-Ischemic Immune Response Improves Outcome in Focal Cerebral Ischemia: A Role for Lymphocytes in Stroke?p. 95
Tumor Necrosis Factor-Alpha (TNF-[alpha]) and Ceramide Induce Tolerance to Ischemic and Hypoxic Insults to Brain and Brain Cells Associated with Changes in NF[kappa]B Functionp. 105
Microglial Proliferation and Cell Cycle Protein Upregulation in the Rat Hippocampus Following Forebrain Ischemiap. 113
A Role for Cerebrovascular Endothelium in Ischemia and Reperfusionp. 121
Neural Stem Cells: Developmental Lessons May Yield Therapeutic Insightsp. 133
Clinical Trials/Neuroprotection
Experimental Neuroprotection: Translation to Human Stroke Trialsp. 137
Factors and Mechanisms Enhancing Susceptibility or Tolerance (Glia)
Acid-Sensitive Ion Channels in Brain. New Modulation of Ischemic Injuryp. 159
In-Vitro Elucidation of Mechanisms Underlying Cell Swelling and Death of Nerve and Glial Cellsp. 167
Endogenous Protection Against Hypoxia/Ischemia in the Brain via Erythropoietinp. 177
Ultrastructural Temporal Profile of the Dying Neuron and Surrounding Astrocytes in the Ischemic Penumbra: Apoptosis or Necrosis?p. 189
The Maturation Phenomenon as an Expression of C.&O. Vogt's Theory of Pathoclisisp. 197
Protection by Apomorphine of Dopaminergic Neurons Following Acute Inhibition of Oxidative Metabolism in Rodentsp. 205
Factors Modulating Neuronal Plasticity and the Course of Maturation Phenomenon in Cerebral Ischemia (Metabolic and Inflammatory Factors)
Marrow Stromal Cells as Restorative Treatment of Neural Injuryp. 217
Protein Aggregation, Unfolded Protein Response and Delayed Neuronal Death after Brain Ischemiap. 225
Slow Progression of Neurologic Impairment after Mild Ischemic Insult in Rodents: Relationship to Metabolic and Histologic Changesp. 239
Comparison of Light Transparency Changes of the Cerebral Cortex during Focal Ischemia and Deathp. 245
Sphingolipids Metabolism Following Cerebral Ischemiap. 251
Preconditioning of Gerbil Brain Reduces Hippocampal Depolarization Time Following Transient Fore-Brain Ischemia: Relationship to CA1 Neuron Injuryp. 265
The Expression of MMPs in CNS Injury has Beneficial Rolesp. 275
Neurogenesis Stem Cell Activation--Repair and Plasticity
Postischemic Hypothermia Fails to Improve Outcome after a Striatal Hemorrhage in Ratsp. 279
Activation of NG2-Positive Oligodendrocyte Progenitor Cells after Focal Ischemia in Rat Brainp. 285
Postischemic Housing in an Enriched Environment Influences Hippocampal Progenitor Cell Differentiation after Focal Cortical Ischemiap. 297
Abstract and Poster Presentations
Estrogen Protects Against Global Ischemia-Induced Neuronal Death and Prevents Activation of Apoptotic Signaling Cascades in the Hippocampal CA1p. 311
Ischemic Preconditioning Prevents Global Ischemia-Induced Downregulation of the AMPA Receptor GluR2 Subunit in the Hippocampal Ca1 but does not Bock Caspase-3 Activation nor Protect against GluR2 Antisense Knockdownp. 313
Acute Recovery and Delayed Changes in Tissue Following Transient Cerebral Hypoxia-Ischemia: Impedance, Electron Microscopy and MR Imaging Studies in Ratsp. 315
A Selective Thrombin Inhibitor Prevents Thrombin-Induced Neuronal Cell Death and Mild Hypothermia Enhances its Neuroprotective Effects Following Transient Focal Ischemia in Ratsp. 317
Zinc Dynamics in the Cerebral Cortex of Adult Mice Following Photothrombotic Strokep. 319
Persistent Neuroprotection against Focal Cerebral Ischemia Induced by Cortical Spreading Depression in Micep. 321
Anatomical, Morphological and Behavioral Assessments of Four Different Models of Strokep. 323
Effects of Endurance Exercise on Recovery Following Focal Ischemic Infarctp. 325
Leukocyte Rolling and Adhesion in Pial Microvessels Following Cerebral Ischemia in the Mouse: Effects of Hypothermiap. 327
Early Hypoxic-Ischemic Changes in Blood Flow, T[subscript 1] Relaxation Time, Apparent Diffusion Coefficient and Water Content in Neonatal Rat Brainp. 331
Increased Expression of nNos Following Cortical Spreading Depression in Rat Brainp. 333
Regional Differences on Free Fatty Acid Accumulations between Upper and Lower Frontal Cortex in Rat Focal Ischemiap. 335
Cerebral Ischemia and the Rat Motor Cortex: Time Course of Dysfunction and the Effects of Differential Rehabilitation Paradigms on Functional Recoveryp. 337
Rehabilitation Induced Cortical Dysfunction Following Focal Ischemic Infarctp. 339
Behavioral Improvement by Activation of Endogenous Progenitors in the Rat Transient Forebrain Ischemia Modelp. 341
Round Table Discussion
5th International Workshop Maturation Phenomenon in Cerebral Ischemia Round Table Discussionp. 345
Subject Indexp. 361
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9783540408741
ISBN-10: 3540408746
Audience: General
Format: Paperback
Language: English
Number Of Pages: 362
Published: February 2004
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6  x 2.01
Weight (kg): 0.54