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Maturation Phenomenon in Cerebral Ischemia III : Defense Mechanisms vs. Apoptosis, Neuronal Recovery and Protection in Cerebral Infarction - Umeo Ito

Maturation Phenomenon in Cerebral Ischemia III : Defense Mechanisms vs. Apoptosis, Neuronal Recovery and Protection in Cerebral Infarction

By: Umeo Ito (Editor), Cesare Fieschi (Editor), Francesco Orzi (Editor), Toshihiko Kuroiwa (Editor), Igor Klatzo (Editor)

Paperback ISBN: 9783540650232
Number Of Pages: 343

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The maturation phenomenon refers to postischemic changes that develop hours or days following an ischemic insult. The delayed neuronal death of CA1 pyramidical cells of the hippocampus is a classic example. The report of the phenomenon has boosted research in this field, as it became evident that ischemic damage is not a sudden event but a process potentially susceptible to therapeutic intervention. In September 1990, the first international symposium on "Maturation Phenomenon in Cerebral Ischemia" was held in Tokyo. The second symposium was organized in Tokyo in March/April 1996. Since then, new developments have rapidly delivered information about the molecular nature and dynamics of mechanisms concerning cell death and recovery. This book contains the presentations of the 3rd international symposium held in Pozilly/Italy in April 1998. It outlines the present status of the investigation and provides further stimulation for research in this field.

Multiple Molecular Penumbras Associated with Focal Ischemia in Brainp. 3
Aspects of Maturation Phenomenon Observed by the TUNEL Methodp. 15
Delayed Gene Expression and Ischemic Brain Injuryp. 25
The Role of Programmed Cell Death in Cerebral Ischemiap. 33
The Role of Caspase-3 Like Protease in the Hippocampus After Transient Global Ischemiap. 41
Alterations in Translation Initiation Following Global Brain Ischemiap. 47
Studies of Neuronal Necrosis and Apoptosis after Global Cerebral Ischemia in Superoxide Dismutase Transgenic and Knockout Mutantsp. 53
Apoptosis-Related Genes Are Expressed in the Rat Model of Subarachnoid Hemorrhagep. 65
No Morphological Evidence of Apoptosis Following Mild to Severe Episodes of Four-Vessel-Occlusion Ischemia in Ratsp. 69
Stimulation of [Beta][subscript 2]-Adrenoceptors Induces Nerve Growth Factor and Inhibits Apoptosis in Rat Brain After Ischemiap. 77
Ischemia-Induced Dynamic Cellular Response in the Brainp. 87
Oxygen Free Radicals and Ischaemic Preconditioning in the Brain: Preliminary Data and a Hypothesisp. 95
Ischemic Tolerance in the Maturation of Disseminated Selective Neuronal Necrosis and Cerebral Infarction After Repetitive Ischemiap. 105
Upregulation of Vascular Endothelial Growth Factor Protein Levels in Global Ischemia Induced by Cardiac Arrest and Resuscitation in Rat Brainp. 111
Neuroprotective Effect of Hepatocyte Growth Factorp. 117
Tumor Necrosis Factor-[alpha]-Induced Ischemic Tolerance as Manifested by Microvascular and Endothelial Cell Responsesp. 127
The Role of Glial and Inflammatory Reactions in Cerebral Ischemiap. 135
Effect of Endothelin[actual symbol not reproducible] Receptor Antagonist on Neuronal Injury in Global and Focal Ischemiap. 143
Lowering of Ameboid Microglial Resistance to Hydrogen Peroxide by Propentofyllinep. 151
Combination Therapy: A Promising Treatment Strategy for Cerebral Ischemiap. 159
Another Facet of Nitric Oxide: Reduction of Toxis Zinc Influx Through Voltage-Gated Channelsp. 169
Slowly Progressive Neuronal Degeneration in Remote Areas After Focal Cerebral Ischemiap. 175
Metabolic Disturbance and Gene Responses Following Cortical Injury in Rats: Relationship to Spreading Depressionp. 183
Protein Expression and Brain Plasticity After Transient Middle Cerebral Artery Occlusion in the Ratp. 193
Alteration of Cyclic Adenosine Monophosphate Binding in Ischemic Brain: Sensitive Metabolic Marker for Early Ischemic Tissue Damagep. 203
Role of Mitochondria in Immediate and Delayed Reperfusion Damagep. 217
Temporal Profile of Cortical Injury Following Ischemic Insult Just Below and at the Threshold Level for Induction of Infarction - Light and Electron Microscopic Studyp. 227
Mitochondrial Dysfunction and Maturation Phenomenon in Ischemic Gerbil Cortexp. 237
Metabolic Ca[superscript 2+] Signalling and Refilling of Ca[superscript 2+] Stores in Hippocampal Astrocytes Are Driven by Adenosine Triphosphate Supplied by Glycolysisp. 243
Brain-Derived Neurotrophic Factor and Ciliary Neurotrophic Factor Treatment of Focal Cerebral Ischemia in Ratp. 251
Environmental Influence on Neurotrophic Gene Expression After Experimental Brain Infarction in the Ratp. 261
Delayed Neuronal Death in Experimental Ischemic Strokep. 267
A Rat Model to Study Damage and Defense Mechanisms Under Penumbra Conditionsp. 275
Instrumental Diagnosis and Treatment of Acute Ischemic Stroke: The Clinician's Perspectivep. 281
Mechanisms of Regulation of Cerebral Blood Flowp. 291
The Protective Effect of DY9760e, a Novel Calmodulin Antagonist, on Rat Permanent Middle Cerebral Artery Occlusionp. 311
Amelioration of Brain Damage Following Transient Focal Ischemia in Rats by ONO-2506: Relevance of Its Modulating Action on Astroglial Functionsp. 313
The Effect of ONO-2506 on Permanent Focal Ischemia in Ratsp. 315
Preconditioning with 5 Min Forebrain Ischemia Ameliorated Mortality and Brain Edema Caused by 15 Min Forebrain Ischemia in the Gerbilp. 317
Alteration of Control Mechanisms of Endoplasmic Reticulum Calcium Pools in Focal Cerebral Ischemiap. 319
Global Ischemia Induces Downregulation of GluR2 mRNA and Increases AMPA Receptor-Mediated Ca[superscript 2+] Influx in Hippocampal CA1 Neuronsp. 321
SPD 502 (NS 1209), a New Selective AMPA Antagonist, Reduces the Infarct Size in Rats Following Permanent Occlusion of the Middle Cerebral Arteryp. 323
Neuroprotective Effects of Magnesium and Tirilazad in Rats Subjected to Transient Focal Cerebral Ischemiap. 325
Do Natural Antioxidants Protect Neurons from Oxidative Stress Due to Their Anti-Radical Activity?p. 327
Carnosine Prevents Neurons from Excitoxic Effects of NMDA and Kainatep. 329
Aspects of Tolerance and Apoptosis: Cell and Molecular Biological Studiesp. 331
Round Table Summaryp. 335
Subject Indexp. 341
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540650232
ISBN-10: 3540650237
Audience: General
Format: Paperback
Language: English
Number Of Pages: 343
Publisher: SPRINGER VERLAG GMBH
Country of Publication: DE
Dimensions (cm): 23.39 x 15.6  x 1.93
Weight (kg): 0.51