Resident mast cells are uniquely positioned in multiple organ systems at either the tissue and/or external environment or located near nerve endings and/or blood vessels. These locations allow the mast cell to serve as a sentinel and thus play a critical role in not only inflammatory situations to promote recruitment and infiltration of other immune cells, but also homeostatic maintenance. Although mast cells have several conserved characteristics, the authors provide evidence that the micro-environment influenced differences in the phenotype of tissue-specific mast cells, control the various responses to injury, inflammation and remodelling. This book brings together the work from experts across multiple tissue/organ systems and inflammatory causes (viral, bacterial, and auto-immune) to present the most up to date knowledge regarding the role of mast cells in these regulatory and disease events.
Role of Mast Cells in Health & Disease; Spatial Patterns in Mast Cell Activation; Mast Cell within the Microenvironment: Cellular & Matrix Cross-talk in Physiopathological Conditions; Mast Cell in Immune Function & Leukocyte Recruitment; The Function of Mast Cells in Innate Immunity: Interaction of Mast Cells with Gram-Negative Bacteria; Presentation, Diagnosis, & Management of Mast Cell Activation Syndrome; Multiple Roles of Mast Cells in Heterotropic Ossification; The Role of Mast Cells in Neoplasm Angiogenesis & Bacterial & Viral Infections; Mast Cells & Their Evolving Role in the Human Testis; Mast Cells in Inflammatory Bowel Disease: Potential Therapeutic Targets for Intestinal Inflammation & Fibrosis; Index.
Series: Cell Biology Research Progress
Number Of Pages: 333
Published: 1st July 2013
Country of Publication: US
Dimensions (cm): 26.0 x 18.0
Weight (kg): 0.78