The current volume represents the fourth over a period of five years in the series on advances in the cellular and molecular biology of breast cancer. Throughout this series, a broad view has been taken at what are cutting edge topics in the basic research into breast cancer. Since the last volume, research in breast cancer has continued to proceed at an explosive rate, and the current volume will provide the reader with some of the excitement felt by the editors and authors. The first section is devoted to the basic process of proliferation, differentiation, and malignant progression of breast cancer. The second section emphasizes the genetic basis for breast cancer onset and malignant progression. The third section deals with growth factors, receptors, and polyamines in proliferation mechanisms. The fourth section is devoted to aspects of metastases and tumor-host interactions. The final section presents recent studies on rodent models of breast cancer.
Foreword to the Series. Preface. I: Proliferation, Differentiation and Malignant Progression. 1. Morphological and biological observations relating to the development and progression of breast cancer; T.J. Anderson, W.R. Miller. 2. Growth, differentiation, and transformation of human mammary epithelial cells in culture; M.R. Stampfer, P. Yaswen. II: Genetic Basis for Cancer Onset and Progression. 1. Genetic analysis of breast and ovarian cancer in families; M.-C. King, S. Rowell. 2. The P53 tumor suppressor gene in human breast cancer; D.C. Allred, R. Elledge, G.M. Clarke, S.A.W. Fuqua. 3. Tumor suppressor genes in breast cancer progression; H.S. Smith. 4. Estrogen receptor variants in breast cancer; C.A. Encarnacion, S.A.W. Fuqua. 5. Hormone 'resistance' in breast cancer: the role of normal and mutant steroid receptors; K.B. Horwitz. III: Growth Factors, Receptors and Polyamines. 1. The epidermal growth factor family in the mammary gland and other target organs for ovarian steroids; R.P. DiAugustine. 2. Molecular and clinical aspects of the neu/erbB2 receptor tyrosine kinase; I. Stancovski, M. Sela, Y. Yardin. 3. MDGF1: a multifunctional growth factor in human milk and human breast cancer; M. Bano, W.R. Kidwell, R.B. Dickson. 4. The role of polyamines in the hormonal control of breast cancer proliferation; A. Manni. IV: Cancer Cell Adhesion, Migration, and Proteolysis. 1. Modulation of the epithelial phenotype during embryogenesis and cancer progression; P. Savagner, B. Boyer, A.M. Valles, J. Jouanneau, J.-P. Thierry. 2. Cell-cell adhesion in invasion and metastases of carcinomas; J. Behrens, W. Birchmeier. 3. Enhancement of tumor growth by basement membrane: modulation of growth and angiogenesis by laminin-derived synthetic peptides; M.C. Kibbey, K. Yamamura, Soo Han Jun, D.S. Grant, H.K. Kleinman. 4. Fetal-like fibroblasts: their production of migration stimulating factor and role in tumor progression; S.L. Schor, A.M. Grey, I. Ellis, A.M. Schor, A. Howell, P. Sloan, R. Murphy. 5. Urokinase plasminogen activator (UPA) and its type 1 inhibitor (PAI-1): regulators of proteolysis during cancer invasion and prognostic parameters in breast cancer; N. Brunner, C. Pyke, C. Holst Hansen, J. Romer, J. Grondahl-Hansen, K. Dano. V: Rodent Model Systems of Breast Cancer. 1. Molecular mechanisms of chemical carcinogenesis in rodent models; K. McKenzie, S. Sukumar. 2. Fgf-3, an oncogene in murine breast cancer; C. Dickson, V. Fantl. Index.
Series: Cancer Treatment and Research
Number Of Pages: 361
Published: December 2009
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5
Weight (kg): 1.56