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Mammalian Amino Acid Transport : Mechanism and Control - D. Haussinger

Mammalian Amino Acid Transport

Mechanism and Control

By: D. Haussinger (Editor), Michael S. Kilberg (Editor)

Hardcover Published: 31st January 1993
ISBN: 9780306443596
Number Of Pages: 318

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Amino acid transport is a part of each of two larger subjects, amino acid metabolism and the biomembrane transport of various . small molecules and ions. Nevertheless in this volume we treat amino acid transport as more than a fragment of either of these two larger subjects. A more comprehensive approach is justified when we remember two historic and ongoing aspects of the title subject. First, amino acid transport had its beginning and acquired a distinct momentum (even if somewhat interrupted from 1913 until about 1945) as amino acid metabolism with the central and pioneer work of Van Slyke and Meyer in 1913. The reviews in this volume will show that it steadily becomes a larger aspect of amino acid metabolism, broadly perceived. These chapters will show for how many organelles, cells, tissues, organs and organ systems, the transmembrane compartmentations and flows of amino acids play very large parts in their fundamental biological relations. The authors here are tending collectively to evaluate an understanding of amino acid flows across biomernbranes, and the regulation of these flows, as necessary to an ultimate understanding of the full range of development and metabolism. Such an understanding goes far beyond the purely substrate-destabilizing contributions by enzymes, which have often been arbitrarily limited to that conceptual entity, "the cell", and which for so long a splendid time had most of biochemical research attention.

General Aspects
Amino Acid Transporters: Systematic Approach and Principles of Controlp. 3
Energetics of Amino Acid Transportp. 31
Techniques Used in the Study of Plasma Membrane Amino Acid Transportp. 51
Molecular Biological Approaches for Amino Acid Transportp. 65
Amino Acid Transport During Embryogenesisp. 75
Amino Acid Transport by Lysosomesp. 89
Amino Acid Transport in Mitochondriap. 101
Amino Acid Transport, Cell Volume and Regulation of Cell Growthp. 113
Tissue Specific Transport and Functional Implications
Amino Acid Transport in Liverp. 133
Amino Acid Transport in Intestinep. 149
Amino Acid Transport in Brainp. 165
Muscle Amino Acid Metabolism and Transportp. 195
Amino Acid Transport in the Kidneyp. 233
Amino Acid Transport in Lymphocytesp. 261
Transport of Cysteinyl Leukotrienesp. 275
Interorgan Glutathione Transportp. 283
Interorgan Amino Acid Nutritionp. 295
Indexp. 305
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306443596
ISBN-10: 0306443597
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 318
Published: 31st January 1993
Publisher: SPRINGER VERLAG GMBH
Country of Publication: US
Dimensions (cm): 25.4 x 17.78  x 1.91
Weight (kg): 0.79