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Major Histocompatibility Complex : Evolution, Structure, and Function - Masanori Kasahara

Major Histocompatibility Complex

Evolution, Structure, and Function

By: Masanori Kasahara (Editor)

Hardcover Published: 1st February 2000
ISBN: 9784431702764
Number Of Pages: 561

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Every biological system is the outcome of evolution and has a history all its own. This history dictates how the system works and why it has certain properties and not others. This is why we need to study not only the structure and function, but also the history of the system. This argument undoubtedly applies to the study of the immune system and also to the study of the major histocompatibility complex (MHC). Since 1989, researchers of various scientific disciplines who share a deep inter­ est in MHC evolution have held a meeting every two years to discuss their latest research developments, exchange ideas, and foster friendship. Together with my colleagues Drs. Naoyuki Takahata and Yoko Satta, I organized the Sixth Interna­ tional Workshop on MHC Evolution in Hayama, Japan, May 25-29, 1999. This volume is the proceedings of that conference. It covers diverse topics pertinent to MHC evolution, including the origin of the adaptive immune system, the organi­ zation of the MHC in humans and other model vertebrates, MHC-parasite co­ evolution, and the nature and origin of MHC polymorphism. I hope that this book will be of interest not only for MHC researchers and immunologists, but also for other specialists who are interested in the evolution of biological systems in gen­ eral.

Jaws and AISp. 3
The MHC paralogous group: listing of members and a brief overviewp. 27
The MHC [[Big-Bang]]: duplication and exon shuffling during chordate evolution. A hypothetico-deductive approachp. 45
Relationships among the genes encoding MHC molecules and the specific antigen receptorsp. 53
Conserved linkage among sea urchin homologs of genes encoded in the vertebrate MHC regionp. 66
Physical mapping of the class I regions of the rat major histocompatibility complexp. 77
MHC gene organization of the bony fish, medakap. 91
Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypesp. 110
Distribution of polypurine/polypyrimidine tract sequences in the human MHC region and their possible functionsp. 131
Potential for paralogous mapping to simplify the genetics of diseases and functions associated with MHC haplotypesp. 146
Transposable elements and the metamerismatic evolution of the HLA class I regionp. 158
Polymorphism in the HLA class I regionp. 178
Nucleotide diversity within the human major histocompatibility complex: function of hitch-hiking effect, duplications, indels and recombinationp. 186
Proteasomes and MHC class I-peptide generationp. 203
Comparative aspects of the MHC class I-related MRI, CD1D, and MIC genes in primatesp. 213
Rat TL and CDIp. 222
Are chicken Rfp-Y class I genes classical or non-classical?p. 236
Xenopus class I proteinsp. 248
Two MHC class II A loci in the channel catfishp. 260
The evolution of MHC class I genes in cattlep. 273
Evidence for four functional DQA loci in cattle with distinct distributions amongst European and African populationsp. 279
The NKC and regulation of natural killer cell-mediated immunityp. 287
Manipulation of MHC-encoded proteins by cytomegalovirusesp. 305
An animal model for understanding the immunogenetics of AIDS virus infectionp. 320
Evolution of HLA-DRB loci, DRB1 lineages, and alleles: analyses of intron-1 and -2 sequencesp. 329
The non-coding regions of HLA-DRB uncover inter-lineage recombinations as a mechanism of HLA diversificationp. 347
Conversion or convergence? Introns of primate DRB genes tell the true storyp. 354
Intron 1 sequence analysis of the MHC-DRB1, 3, 4, 5, and 6 genes in five non-human primate speciesp. 377
Evolution of Catarrhini DPB1 exon 2 under intragenic recombinationp. 386
The effect of mutation, recombination and selection of HLA non-coding sequencesp. 398
HLA-DQ haplotypes in 15 different populationsp. 412
HLA class I and class II loci in Pacific/Asian populationsp. 427
HLA class I alleles in Australian aborigines and their peptide binding profilesp. 446
An evolutionary overview of the MHC-G polymorphism: clues to the unknown function(s)p. 463
MIC-A polymorphism and a MIC-A-MIC-B null haplotype with 100-kb deletionp. 480
Repertoire forecast of MHC class I binding peptides with peptide librariesp. 487
Sequence conditions for gene conversion of mouse MHC genesp. 503
Mhc class II genes of Darwin's Finches: divergence by point mutations and reciprocal recombinationp. 518
Contrasting patterns of MHC and microsatellite diversity in social and solitary tuco-tucos (Rodentia: Ctenomyidae)p. 542
Author indexp. 555
Key word indexp. 559
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9784431702764
ISBN-10: 4431702768
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 561
Published: 1st February 2000
Publisher: Springer Verlag, Japan
Country of Publication: JP
Dimensions (cm): 23.5 x 15.88  x 3.18
Weight (kg): 1.04