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Macromolecular Crystallography : Part A - John N. Abelson

Macromolecular Crystallography

Part A

By: John N. Abelson (Editor), Melvin I. Simon (Editor), Charles W. Carter (Editor), Robert M. Sweet (Editor)

Hardcover

Published: 1st February 1997
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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 270 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.
Key Features
* Crystal Growth
* Phase Determination
* Instrumentation and Data Collection
* Model Building
* Refinement

Praise for the Series "The Methods in Enzymology series represents the gold-standard." --NEUROSCIENCE "Incomparably useful." --ANALYTICAL BIOCHEMISTRY "It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page." --BIO/TECHNOLOGY "The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection." --CHEMISTRY IN INDUSTRY "The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced." --AMERICAN SOCIETY OF MICROBIOLOGY NEWS "If we had some way to find the work most often consulted in the laboratory, it could well be the multi-volume series Methods in Enzymology...a great work." --ENZYMOLOGIA "A series that has established itself as a definitive reference for biochemists." --JOURNAL OF CHROMATOGRAPHY

Introduction
Recent Transformations in Structural Biology
Crystals
Overview of Protein Crystallization Methods
Inferences Drawn from Physicochemical Studies of Crystallogenesis and Precrystalline State
Membrane Protein Crystallization: Application of Sparse Matrix to alpha-Hemolysin Heptamer
Response Surface Methods for Optimizing and Improving Reproducibility of Crystal Growth
Second Virial Coefficient as Predictor in Protein Crystal Growth
Kinetic Aspects of Macromolecular Crystallization
Using Cosolvents to Stabilize Protein Conformation for Crystallization
Preparation and Crystallization of RNA: A Sparse Matrix Approach
Dynamic Light Scattering in Evaluating Crystallizability of Macromolecules
Two-Dimensional Protein Crystals in Aid of Three-Dimensional Protein Crystal Growth
Reductive Alkylation of Lysine Residues to Alter Crystallization Properties of Proteins
Data: Cryocrystallography
Practical Cryocrystallography
Overview of Synchrotron Radiation and Macromolecular Crystallography
Neutron Macromolecular Crystallography
Detectors
X-Ray Storage-Phosphor Imaging-Plate Detectors: High-Sensitivity X-Ray Area Detector
Charge-Coupled Device-Based Area Detectors
Gas Proportional Detectors
Data Collection Software
Diffraction-Data Processing for Electronic Detectors: Theory and Practice
Processing of X-Ray Diffraction Data Collected in Oscillation Mode
Data Collection Strategy
Detecting and Overcoming Crystal Twinning
Phases: Basic Concepts
Bayesian Statistical Viewpoint on Structure Determination: Basic Concepts and Examples
Efficient Sampling Methods for Combinations of Signs
Phases, Hyperphases, and Molecular Orientations
Overview of Isomorphous Replacement Phasing
Screening for Heavy-Atom Derivatives and Obtaining Accurate Isomorphous Differences
Maximum-Likelihood Heavy-Atom Parameter Refinement for Multiple Isomorphous Replacement and Multiwavelength Anomalous Diffraction Methods
Multiwavelength Methods
Phase Determination by Multiwavelength Anomalous Diffraction Methods
Preparation of Selenomethionyl Proteins for Phase Determination
Multiwavelength Anomalous Diffraction Phasing of Macromolecular Structures: Analysis of MAD Data as Single Isomorphous Replacement with Anomalous Scattering Data Using MADMRG Program
Treatment of Multiwavelength Anomalous Diffraction Data as a Special Case of Multiple Isomorphous Replacement
Molecular Replacement
Patterson Correlation Searches and Refinement
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780121821777
ISBN-10: 0121821773
Series: Methods in Enzymology : Book 276
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 700
Published: 1st February 1997
Publisher: Elsevier Science Publishing Co Inc
Country of Publication: US
Dimensions (cm): 22.9 x 15.2  x 4.4
Weight (kg): 1.11