In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP is thought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is it the actual neural mechanism used by the brain to store information?
This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research that cover the range of molecular, cellular, physiological and behavioral approaches to the study of LTP. Provocative, accessible and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today.
"from other books by this editor As a reference work for those working in any field related to EAA and NMDA receptors, this book is invaluable. Much of the history of the field of excitatory amino acids is contained within this book. I recommend it to the neuroscience researcher, as well as the clinician who wishes to have a reference work on the NMDA receptor on the bookshelf."
T Bliss, G Collingridge & R Morris: Introduction
Foreword by Colin Blakemore
1: P Andersen: A prelude to long-term potentiation
2: T Lomo: The discovery of long-term potentiation
3: T Bliss: A journey from neocortex to hippocampus
4: G Lynch: Long-term potentiation in the Eocene
5: B McNaughton: Long-term potentiation, cooperativity and Hebb's cell assemblies: a personal history
6: G Collingridge: The induction of N-methyl-D-aspartate receptor-dependent long-term potentiation
7: R Morris: Long-term potentiation and memory
8: M Bear: Bidirectional synaptic plasticity: from theory to reality
9: Z Bortolotto, S Lauri, J Isaac & G Collingridge: Kainate receptors and the induction of mossy fibre long-term potentiation
10: D Johnston, B Christie, A Frick, R Gray, D Hoffman, L Schexnayder, S Watanabe & L-L Yuan: Active dendrites, potassium channels and synaptic plasticity
11: M Errington, P Galley & T Bliss: Long-term potentiation in the dentate gyrus of the anaesthetized rat is accompanied by an increase in extracellular glutamate: real-time measurements using a novel dialysis electrode
12: T Hosokawa, M Ohta, T Saito & A Fine: Imaging spatio-temporal patterns of long-term potentiation in mouse hippocampus
13: S Choi, J Klingauf & R Tsien: Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation
14: R Malinow: AMPA receptor trafficking and long-term potentiation
15: F Duprat, M Daw, W Lim, G Collingridge & J Isaac: GluR2 protein-protein interactions and the reulation of AMPA receptors during synaptic plasticity
16: R Nicoll: Expression mechanisms underlying long-term potentiation: a postsynaptic view
17: D Kullmann: Silent synapses: what are they telling us about long-term potentiation?
18: W Abraham: How long will long-term potentiation last?
19: K Harris, J Fiala & L Ostroff: Structural changes at dendritic spine synapses during long-term potentiation
20: E Schuman & S Murase: Cadherins and synaptic plasticity: activity-dependent cyclin-dependent kinase 5 regulation of synaptic beta-catenin-cadherin interactions
21: C Pittenger & E Kandel: In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus
22: C Barnes: Long-term potentiation and the ageing brain
23: R Morris, E Moser, G Riedel, S Martin, J Sandin, M Day and C O'Carroll: Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory
24: S Tonegawa, K Nakazawa & M Wilson: Genetic neuroscience of mammalian learning and memory
25: G Hedou & I Mansuy: Inducible molecular switches for the study of long-term potentiation
26: B Bozon, A Kelly, S Josselyn, A Silva, S Davis & S Laroche: MAPK, CREB and zif268 are all required for the consolidation of recognition memory
27: M Thomas & R Malenka: Synaptic plasticity in the mesolimbic dopamine system
28: M Rowan, I Klyubin, W Cullen & R Anwyl: Synaptic plasticity in animal models of early Alzheimer's disease
29: J Lisman: Long-term potentiation: outstanding questions and attempted synthesis
Series: Enhancing Neuroscience for 30 Years
Number Of Pages: 420
Published: 1st April 2004
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 24.8 x 17.3
Weight (kg): 0.96