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Long-term Potentiation : Enhancing neuroscience for 30 years - Timothy Bliss

Long-term Potentiation

Enhancing neuroscience for 30 years

By: Timothy Bliss (Editor), Graham Collingridge (Editor), Richard Morris (Editor)

Hardcover Published: 1st April 2004
ISBN: 9780198530305
Number Of Pages: 420

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In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP is thought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is it the actual neural mechanism used by the brain to store information?
This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research that cover the range of molecular, cellular, physiological and behavioral approaches to the study of LTP. Provocative, accessible and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today.

Industry Reviews

"from other books by this editor As a reference work for those working in any field related to EAA and NMDA receptors, this book is invaluable. Much of the history of the field of excitatory amino acids is contained within this book. I recommend it to the neuroscience researcher, as well as the clinician who wishes to have a reference work on the NMDA receptor on the bookshelf."

T Bliss, G Collingridge & R Morris: Introduction Foreword by Colin Blakemore History 1: P Andersen: A prelude to long-term potentiation 2: T Lomo: The discovery of long-term potentiation 3: T Bliss: A journey from neocortex to hippocampus 4: G Lynch: Long-term potentiation in the Eocene 5: B McNaughton: Long-term potentiation, cooperativity and Hebb's cell assemblies: a personal history 6: G Collingridge: The induction of N-methyl-D-aspartate receptor-dependent long-term potentiation 7: R Morris: Long-term potentiation and memory Induction 8: M Bear: Bidirectional synaptic plasticity: from theory to reality 9: Z Bortolotto, S Lauri, J Isaac & G Collingridge: Kainate receptors and the induction of mossy fibre long-term potentiation 10: D Johnston, B Christie, A Frick, R Gray, D Hoffman, L Schexnayder, S Watanabe & L-L Yuan: Active dendrites, potassium channels and synaptic plasticity Expression 11: M Errington, P Galley & T Bliss: Long-term potentiation in the dentate gyrus of the anaesthetized rat is accompanied by an increase in extracellular glutamate: real-time measurements using a novel dialysis electrode 12: T Hosokawa, M Ohta, T Saito & A Fine: Imaging spatio-temporal patterns of long-term potentiation in mouse hippocampus 13: S Choi, J Klingauf & R Tsien: Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation 14: R Malinow: AMPA receptor trafficking and long-term potentiation 15: F Duprat, M Daw, W Lim, G Collingridge & J Isaac: GluR2 protein-protein interactions and the reulation of AMPA receptors during synaptic plasticity 16: R Nicoll: Expression mechanisms underlying long-term potentiation: a postsynaptic view 17: D Kullmann: Silent synapses: what are they telling us about long-term potentiation? Persistence 18: W Abraham: How long will long-term potentiation last? 19: K Harris, J Fiala & L Ostroff: Structural changes at dendritic spine synapses during long-term potentiation 20: E Schuman & S Murase: Cadherins and synaptic plasticity: activity-dependent cyclin-dependent kinase 5 regulation of synaptic beta-catenin-cadherin interactions 21: C Pittenger & E Kandel: In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus Function 22: C Barnes: Long-term potentiation and the ageing brain 23: R Morris, E Moser, G Riedel, S Martin, J Sandin, M Day and C O'Carroll: Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory 24: S Tonegawa, K Nakazawa & M Wilson: Genetic neuroscience of mammalian learning and memory 25: G Hedou & I Mansuy: Inducible molecular switches for the study of long-term potentiation 26: B Bozon, A Kelly, S Josselyn, A Silva, S Davis & S Laroche: MAPK, CREB and zif268 are all required for the consolidation of recognition memory New Directions 27: M Thomas & R Malenka: Synaptic plasticity in the mesolimbic dopamine system 28: M Rowan, I Klyubin, W Cullen & R Anwyl: Synaptic plasticity in animal models of early Alzheimer's disease 29: J Lisman: Long-term potentiation: outstanding questions and attempted synthesis

ISBN: 9780198530305
ISBN-10: 0198530307
Series: Enhancing Neuroscience for 30 Years
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 420
Published: 1st April 2004
Publisher: Oxford University Press
Country of Publication: GB
Dimensions (cm): 24.8 x 17.3  x 2.9
Weight (kg): 0.96