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Local Therapies for Glioma : Present Status and Future Developments - M Westphal

Local Therapies for Glioma

Present Status and Future Developments

By: M Westphal (Editor), Z Ram (Editor), J-C Tonn (Editor)

Hardcover Published: 29th August 2003
ISBN: 9783211403556
Number Of Pages: 186

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In addition to surgery and radiotherapy, local treatment modalities for the management of brain tumours are increasingly being developed and clinically tested. This book describes for the first time basic tumour biology as well as all current procedures in progress at the most recent level of knowledge, presented by leading experts in the respective fields. Image guided resection procedures, fluorescence guided surgery, developments in interstitial radiosurgery are addressed, just as intracavitary chemotherapy and all current concepts and studies of interstitial targeted therapy. Owing to its topicality this book will remain for long the standard for this comprehensively treated subject.

Editors' remarks: Evolving concepts for local therapies for gliomap. VII
Intraoperative imaging--MRIp. 1
Stereotactic volumetric resection of gliomasp. 5
Fluorescence-guided resections of malignant gliomas--an overviewp. 9
Postoperative imaging after brain tumor resectionp. 13
Preliminary experience in glioma surgery with intraoperative high-field MRIp. 21
Awake craniotomy in glioma surgeryp. 31
External beam and conformal radiotherapy in the management of gliomasp. 37
Interstitial stereotactic radiosurgeryp. 45
Implantable drug-releasing biodegradable microspheres for local treatment of brain gliomap. 51
Non-invasive transcranial High Intensity Focused Ultrasound (HIFUS) under MRI thermometry and guidance in the treatment of brain lesionsp. 57
Intracavitary chemotherapy for glioblastoma: present status and future directionsp. 61
Intralesional radioimmunotherapy in the treatment of malignant glioma: clinical and experimental findingsp. 69
Intracavitary treatment of malignant gliomas: radioimmunotherapy targeting fibronectinp. 77
Comparing monoclonal antibodies and small peptidic hormones for local targeting of malignant gliomasp. 83
Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant gliomap. 93
Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studiesp. 105
Oncolytic viruses for treatment of malignant brain tumoursp. 113
Gene therapy of gliomasp. 125
Cell therapy using encapsulated cells producing endostatinp. 137
Stem cells in neuro-oncology--development, regeneration and treatmentp. 143
Glioma invasion--Pattern of dissemination by mechanisms of invasion and surgical intervention, pattern of gene expression and its regulatory control by tumorsuppressor p53 and proto-oncogene ETS-1p. 153
Mechanisms of glioma cell invasionp. 163
Invasion as limitation to anti-angiogenic glioma therapyp. 169
Author Indexp. 179
Index of Keywordsp. 181
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9783211403556
ISBN-10: 3211403558
Series: Acta Neurochirurgica Supplement
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 186
Published: 29th August 2003
Country of Publication: AT
Dimensions (cm): 27.9 x 21.0  x 1.35
Weight (kg): 1.01