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Liver Diseases and Hepatic Sinusoidal Cells - Kyuichi Tanikawa

Liver Diseases and Hepatic Sinusoidal Cells

By: Kyuichi Tanikawa (Editor), Takato Ueno (Editor)

Hardcover Published: 1999
ISBN: 9784431702375
Number Of Pages: 348

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Hepatic sinusoidal cells such as sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, and pit cells play an important role in hemodynamic and metabolic function and are involved in various liver diseases. The frequent involvement of sinusoidal cells in pathologic conditions is explained by the diverse actions of those cells, an understanding of which is essential to clinicians. Generously illustrated, this volume presents results of recent studies on hepatic sinusoidal cells in liver diseases, with an introduction to the structure and function of the various types of sinusoidal cells. The in-depth focus of the book is on the role of hepatic sinusoidal cells in relation to liver injury and regeneration, hepatic sinusoidal microcirculation, alcoholic liver diseases, hepatic fibrosis, liver tumor, liver transplantation, cholestasis, and congenital lipidosis, thus providing a valuable reference source for practitioners and researchers.

Preface
List of Contributors
Introduction
The Intestine, Spleen, and Liverp. 3
Hepatic Sinusoidal Cells: Characteristics and Special Topics
Endothelial Cells of the Hepatic Sinusoids: A Reviewp. 17
Hepatic Stellate Cellsp. 56
Development, Differentiation, and Host Defense Function of Kupffer Cellsp. 66
Pit Cells as Liver-Associated Natural Killer Cellsp. 76
Liver Diseases and Hepatic Sinusoidal Cells
Changes in Adhesion Molecules of Sinusoidal Endothelial Cells in Liver Injuryp. 91
The Role of Hepatic Sinusoidal Cells in the Development of Massive Liver Necrosisp. 101
Sinusoidal Endothelial Cells in Liver Regenerationp. 114
Angiogenesis of Cultured Rat Sinusoidal Endothelial Cellsp. 124
The Multiple Roles of Macrophages in Hepatic Granuloma Formation in Micep. 128
Roles of Sinusoidal Endothelial Cells in the Local Regulation of Hepatic Sinusoidal Blood Flow - Involvement of Endothelins and Nitric Oxidep. 141
Hepatic Innervation and Hepatic Sinusoidal Cellsp. 156
Contraction and Relaxation of Ito Cellsp. 168
Portal Hypertension and the Hepatic Sinusoidp. 178
Role of Sinusoidal Endothelial Cells in Alcoholic Liver Diseasep. 190
The Role of Neutrophils in Liver Cell Injury in Alcoholic Hepatitisp. 199
Ethanol-Induced Perturbation of Hepatic Microcirculation: Roles of Endothelin-1 and Nitric Oxide in Regulation of Sinusoidal Tonep. 209
Morphological Aspects of Hepatic Fibrosis and Ito Cells (Hepatic Stellate Cells), with Special Reference to Their Myofibroblastic Transformationp. 219
Retinoids and Liver Fibrosisp. 232
Hepatic Fibrolysis and Hepatic Sinusoidal Cellsp. 242
Diagnosis and Treatment of Hepatic Fibrosis and Hepatic Sinusoidal Cellsp. 252
Anti-Fibrotic Agent Reduces Enzyme-Altered Lesions and Neoplasms in the Rat Liverp. 263
VEGF Participates in Neovascularization and Sinusoidal Capillarization in HCCp. 274
Natural Killer Cells in the Liver and Their Activatorsp. 288
Modulation of Hepatic Sinusoidal Cell Function by Transduction of Genes in the Liver: Gene Therapy for Hepatic Micro-Metastasisp. 296
Morphological Aspects of Hepatic Sinusoidal Walls in Reperfusion Injury after Liver Preservation for Liver Transplantationp. 307
Ultrastructural and Functional Alteration in Hepatic Sinusoidal Cells in Cold-Preserved Rat Liverp. 318
Cholestasis and Hepatic Sinusoidal Cellsp. 327
Congenital Lipidosisp. 337
Key Word Indexp. 347
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9784431702375
ISBN-10: 4431702377
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 348
Published: 1999
Publisher: Springer Verlag, Japan
Country of Publication: JP
Dimensions (cm): 23.5 x 15.5  x 2.1
Weight (kg): 0.71